Advancing Innovative Stem Cell-based Therapy for Diabetes in Europe

Informazioni relative al progetto

ISLET

ID dell’accordo di sovvenzione: 874839

DOI 10.3030/874839

Data della firma CE 12 Dicembre 2019

Data di avvio 1 Marzo 2020

Data di completamento 28 Febbraio 2025

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale € 7 999 998,75

Contributo UE € 7 999 998,75

Coordinato da

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany

Risultati finali

Websites, patent fillings, videos etc. (4)

Dissemination of non-confidential summaries of the project and exploitation plans at prominent biotech conferences, forums and meetings including BioEurope, BioFIT and BIO to promote and establish partnerships relevant to ISLET 3

Dissemination of nonconfidential summaries of the project and exploitation plans at prominent biotech conferences forums and meetings including BioEurope BioFIT and BIO to promote and establish partnerships relevant to ISLET

Dissemination of non-confidential summaries of the project and exploitation plans at prominent biotech conferences, forums and meetings including BioEurope, BioFIT and BIO to promote and establish partnerships relevant to ISLET 1

Dissemination of nonconfidential summaries of the project and exploitation plans at prominent biotech conferences forums and meetings including BioEurope BioFIT and BIO to promote and establish partnerships relevant to ISLET

Project website development and launch, ongoing news feed and update about the project, internal project communication of project documents in members area 1

Project website development and launch ongoing news feed and update about the project internal project communication of project documents in members area

Dissemination of non-confidential summaries of the project and exploitation plans at prominent biotech conferences, forums and meetings including BioEurope, BioFIT and BIO to promote and establish partnerships relevant to ISLET 2

Dissemination of nonconfidential summaries of the project and exploitation plans at prominent biotech conferences forums and meetings including BioEurope BioFIT and BIO to promote and establish partnerships relevant to ISLET

Other (2)

Building capacity for public engagement at partner institutions: Resources created for digital and face-to-face engagement, initial gap analysis, and to support engagement activities by ISLET 1

Building capacity for public engagement at partner institutions Resources created for digital and facetoface engagement initial gap analysis and to support engagement activities by ISLET

Report on active participation in European outreach and engagement events 1

Report on active participation in European outreach and engagement events: network of partner science engagement champions and partner public engagement professionals, ongoing dissemination of local opportunities for engagement and mentoring, contribution to World Diabetes Day (14 November), European City of Science Festival 2022 Leiden, and Long Night of the Sciences across Germany

Pubblicazioni

Peer reviewed articles (6)

Human stomach tissue as alternative source of insulin-producing cells

Autori: Eelco J. P. de Koning, Françoise Carlotti
Pubblicato in: Nature Reviews: Endocrinology, Numero Volume 19, issue 9, 2023, Pagina/e 503-504, ISSN 1759-5029
Editore: Nature Publishing Group
DOI: 10.1038/s41574-023-00867-8

A 3D atlas of the human developing pancreas to explore progenitor proliferation and differentiation

Autori: Adrian Villalba, Yorick Gitton, Megumi Inoue, Virginie Aiello, Raphaël Blain, Maryne Toupin, Séverine Mazaud-Guittot, Latif Rachdi, Henrik Semb, Alain Chédotal, Raphaël Scharfmann
Pubblicato in: Diabetologia, Numero 12 issues a year, 2024, Pagina/e 1066–1078, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-024-06143-2

Generation of pancreatic β cells from CD177+ anterior definitive endoderm

Autori: Pallavi U. Mahaddalkar, Katharina Scheibner, Sandra Pfluger, Ansarullah, Michael Sterr, Julia Beckenbauer, Martin Irmler, Johannes Beckers, Sebastian Knöbel, Heiko Lickert
Pubblicato in: Nature Biotechnology, Numero 38/9, 2020, Pagina/e 1061-1072, ISSN 1087-0156
Editore: Nature Publishing Group
DOI: 10.1038/s41587-020-0492-5

Synchro-PASEF Allows Precursor-Specific Fragment Ion Extraction and Interference Removal in Data-Independent Acquisition

Autori: Patricia Skowronek, Florian Krohs, [...], and Matthias Mann
Pubblicato in: Molecular & Cellular Proteomics, 2023, ISSN 1535-9476
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.mcpro.2022.100489

Engineering islets from stem cells for advanced therapies of diabetes

Autori: Johanna Siehler, Anna Karolina Blöchinger, Matthias Meier, Heiko Lickert
Pubblicato in: Nature Reviews Drug Discovery, 2021, ISSN 1474-1776
Editore: Nature Publishing Group
DOI: 10.1038/s41573-021-00262-w

A transcriptional cross species map of pancreatic islet cells

Autori: Sophie Tritschler, Moritz Thomas, Anika Böttcher, Barbara Ludwig, Janine Schmid, Undine Schubert, Elisabeth Kemter, Eckhard Wolf, Heiko Lickert, Fabian J. Theis,
Pubblicato in: Molecular Metabolism,, 2022, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2022.101595

Other (1)

Awaking sleeping islets for a cure of diabetes

Autori: Katharina Scheibner, Heiko Lickert
Pubblicato in: 2022
Editore: Cell Press
DOI: 10.1016/j.medj.2022.04.004