Advancing Innovative Stem Cell-based Therapy for Diabetes in Europe

Projektinformationen

ISLET

ID Finanzhilfevereinbarung: 874839

DOI 10.3030/874839

EK-Unterschriftsdatum 12 Dezember 2019

Startdatum 1 März 2020

Enddatum 28 Februar 2025

Finanziert unter

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Gesamtkosten € 7 999 998,75

EU-Beitrag € 7 999 998,75

Koordiniert durch

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany

Leistungen

Websites, patent fillings, videos etc. (4)

Dissemination of non-confidential summaries of the project and exploitation plans at prominent biotech conferences, forums and meetings including BioEurope, BioFIT and BIO to promote and establish partnerships relevant to ISLET 3

Dissemination of nonconfidential summaries of the project and exploitation plans at prominent biotech conferences forums and meetings including BioEurope BioFIT and BIO to promote and establish partnerships relevant to ISLET

Dissemination of non-confidential summaries of the project and exploitation plans at prominent biotech conferences, forums and meetings including BioEurope, BioFIT and BIO to promote and establish partnerships relevant to ISLET 1

Dissemination of nonconfidential summaries of the project and exploitation plans at prominent biotech conferences forums and meetings including BioEurope BioFIT and BIO to promote and establish partnerships relevant to ISLET

Project website development and launch, ongoing news feed and update about the project, internal project communication of project documents in members area 1

Project website development and launch ongoing news feed and update about the project internal project communication of project documents in members area

Dissemination of non-confidential summaries of the project and exploitation plans at prominent biotech conferences, forums and meetings including BioEurope, BioFIT and BIO to promote and establish partnerships relevant to ISLET 2

Dissemination of nonconfidential summaries of the project and exploitation plans at prominent biotech conferences forums and meetings including BioEurope BioFIT and BIO to promote and establish partnerships relevant to ISLET

Other (2)

Building capacity for public engagement at partner institutions: Resources created for digital and face-to-face engagement, initial gap analysis, and to support engagement activities by ISLET 1

Building capacity for public engagement at partner institutions Resources created for digital and facetoface engagement initial gap analysis and to support engagement activities by ISLET

Report on active participation in European outreach and engagement events 1

Report on active participation in European outreach and engagement events: network of partner science engagement champions and partner public engagement professionals, ongoing dissemination of local opportunities for engagement and mentoring, contribution to World Diabetes Day (14 November), European City of Science Festival 2022 Leiden, and Long Night of the Sciences across Germany

Veröffentlichungen

Peer reviewed articles (6)

Human stomach tissue as alternative source of insulin-producing cells

Autoren: Eelco J. P. de Koning, Françoise Carlotti
Veröffentlicht in: Nature Reviews: Endocrinology, Ausgabe Volume 19, issue 9, 2023, Seite(n) 503-504, ISSN 1759-5029
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41574-023-00867-8

A 3D atlas of the human developing pancreas to explore progenitor proliferation and differentiation

Autoren: Adrian Villalba, Yorick Gitton, Megumi Inoue, Virginie Aiello, Raphaël Blain, Maryne Toupin, Séverine Mazaud-Guittot, Latif Rachdi, Henrik Semb, Alain Chédotal, Raphaël Scharfmann
Veröffentlicht in: Diabetologia, Ausgabe 12 issues a year, 2024, Seite(n) 1066–1078, ISSN 0012-186X
Herausgeber: Springer Verlag
DOI: 10.1007/s00125-024-06143-2

Generation of pancreatic β cells from CD177+ anterior definitive endoderm

Autoren: Pallavi U. Mahaddalkar, Katharina Scheibner, Sandra Pfluger, Ansarullah, Michael Sterr, Julia Beckenbauer, Martin Irmler, Johannes Beckers, Sebastian Knöbel, Heiko Lickert
Veröffentlicht in: Nature Biotechnology, Ausgabe 38/9, 2020, Seite(n) 1061-1072, ISSN 1087-0156
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41587-020-0492-5

Synchro-PASEF Allows Precursor-Specific Fragment Ion Extraction and Interference Removal in Data-Independent Acquisition

Autoren: Patricia Skowronek, Florian Krohs, [...], and Matthias Mann
Veröffentlicht in: Molecular & Cellular Proteomics, 2023, ISSN 1535-9476
Herausgeber: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.mcpro.2022.100489

Engineering islets from stem cells for advanced therapies of diabetes

Autoren: Johanna Siehler, Anna Karolina Blöchinger, Matthias Meier, Heiko Lickert
Veröffentlicht in: Nature Reviews Drug Discovery, 2021, ISSN 1474-1776
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41573-021-00262-w

A transcriptional cross species map of pancreatic islet cells

Autoren: Sophie Tritschler, Moritz Thomas, Anika Böttcher, Barbara Ludwig, Janine Schmid, Undine Schubert, Elisabeth Kemter, Eckhard Wolf, Heiko Lickert, Fabian J. Theis,
Veröffentlicht in: Molecular Metabolism,, 2022, ISSN 2212-8778
Herausgeber: Elsevier GmbH
DOI: 10.1016/j.molmet.2022.101595

Other (1)

Awaking sleeping islets for a cure of diabetes

Autoren: Katharina Scheibner, Heiko Lickert
Veröffentlicht in: 2022
Herausgeber: Cell Press
DOI: 10.1016/j.medj.2022.04.004