Descripción del proyecto
Matrices para la regeneración de huesos gracias a la impresión 3D
La reconstrucción ósea constituye un gran reto médico, puesto que los autoinjertos no son adecuados para daños óseos de gran tamaño y los aloinjertos son complicados a causa del rechazo inmunológico. El proyecto financiado con fondos europeos SBR desarrolla un enfoque de implante inteligente para una regeneración rápida y controlable. La solución propuesta implica la creación de matrices de polímeros de uso médico impresas en 3D con células madre integradas y factores bioactivos adaptados a la fisiología y la patología del paciente. Además, el diseño de la matriz permitirá añadir diversos sensores para supervisar el rendimiento de los implantes basándose en tintas de impresión 3D conductivas y biocompatibles. Por último, el proyecto comprobará la prueba de concepto «in vivo» en estudios con modelos animales grandes y, además, elaborará la estrategia normativa y de comercialización para los futuros ensayos clínicos.
Objetivo
The management and reconstruction of bone defects is a significant global healthcare challenge. While autografts offer ideal compatibility, they are often not suitable for large bone defects, and allografts suffer from potential immunorejection.The limited efficacy of conventional treatment strategies for large bone defects and the increasing aged population, has inspired the consortium to propose a SMART RESORBABLE BONE (SRB) IMPLANT embedding stem cells and bioactive agents with the aim of a controllable and fast restoration. The proposed solution includes 3D printed medical grade polymers enriched with electrospun fibers (for increased mechanical properties) that can be customized for patient physiology, pathology, and gender. The scaffold design will ensure easy and minimal Injury placement, and will embed different sensors for monitoring e.g. pressure, pH value and temperature based on biocompatible conductive inks. The smart implant will thus be able to provide vital information of implant performance in terms of bone growth and infection/inflammation. The proposed method is unique because it includes a customized smart implant (3D printed parts with adjustable sensors and communication electronic system), together with tissue engineering methods i.e. in-vitro programming of stem cells for embedding into the smart implant. The proposed solution introduces an innovative regenerative chain, from early testing and characterization (identification/adjustement of the proper specifications) and embedding regenerative stem cells and particulate bioactive agents into the smart implant in preclinical research (in-vitro). The in vivo proof of concept of SBR solution will be tested in (large animal model) preclinical studies within the scope of the project. Finally the regulatory and commercialization strategy on how to further explore the proposed concept and deliver it for clinical testing will be elaborated.
Ámbito científico
- medical and health sciencesmedical biotechnologytissue engineering
- medical and health sciencesmedical biotechnologycells technologiesstem cells
- engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensors
- medical and health sciencesbasic medicinepathology
- medical and health sciencesmedical biotechnologyimplants
Palabras clave
Programa(s)
Convocatoria de propuestas
Consulte otros proyectos de esta convocatoriaConvocatoria de subcontratación
H2020-SC1-2019-Single-Stage-RTD
Régimen de financiación
RIA - Research and Innovation actionCoordinador
265 04 Rio Patras
Grecia