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Prioritisation and Risk Evaluation of Medicines in the EnviRonment

Objective

There are around 1900 active pharmaceutical ingredients (APIs) in use, yet the environmental risks of only a small proportion of these has been assessed. This calls for pragmatic science-based approaches for prioritising existing APIs in terms of their environmental risk. Such approaches could also be used pro-actively, i.e. to identify environmental concerns earlier in the drug development process, thereby contributing to a more sustainable future. The overall aim of PREMIER is to deliver an API information and assessment system for characterising the potential environmental risks of APIs, including relevant human metabolites and environmental transformation products, based on minimal testing. This system will be designed to screen and prioritise legacy APIs for tailored environmental assessment; identify potential environmental hazards associated with APIs in development; and to make the available environmental data more accessible for all stakeholders. The system will be optimized and validated using case studies on approximately 25 APIs. PRIME will realize its aim by combining world-leading research on the environmental risks of APIs with the principles of co-design and smart knowledge-based IT. Through this combination, we want to be more than a conventional research project. We want to ensure that the results of our ground-breaking research “work” address all the societal concerns about the potential risks posed by the presence of pharmaceuticals in the environment.

Call for proposal

H2020-JTI-IMI2-2019-17-two-stage
See other projects for this call

Funding Scheme

IMI2-RIA - Research and Innovation action

Coordinator

STICHTING KATHOLIEKE UNIVERSITEIT
Address
Geert Grooteplein Noord 9
6525 EZ Nijmegen
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 755 803

Participants (24)

UNIVERSITY OF YORK
United Kingdom
EU contribution
€ 384 836,25
Address
Heslington
YO10 5DD York North Yorkshire
Activity type
Higher or Secondary Education Establishments
ECT OEKOTOXIKOLOGIE GMBH
Germany
EU contribution
€ 363 497,50
Address
Bottgerstrasse 2-14
65439 Florsheim
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU
Netherlands
EU contribution
€ 288 385
Address
Antonie Van Leeuwenhoeklaan 9
3721 MA Bilthoven
Activity type
Research Organisations
ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI
Italy
EU contribution
€ 224 375
Address
Via Mario Negri 2
20156 Milano
Activity type
Research Organisations
EIDGENOESSISCHE ANSTALT FUER WASSERVERSORGUNG ABWASSERREINIGUNG UND GEWAESSERSCHUTZ
Switzerland
EU contribution
€ 296 497,50
Address
Uberlandstrasse 133
8600 Dubendorf
Activity type
Other
LEUPHANA UNIVERSITAT LUNEBURG
Germany
EU contribution
€ 199 500
Address
Scharnhorststrasse 1
21335 Luneburg
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY OF EXETER
United Kingdom
EU contribution
€ 383 145,90
Address
The Queen's Drive Northcote House
EX4 4QJ Exeter
Activity type
Higher or Secondary Education Establishments
TEAM - IT RESEARCH SL
Spain
EU contribution
€ 326 875
Address
Passe De Gracia 58 Planta 4 Puerta 2
08007 Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SIMOMICS LIMITED
United Kingdom
EU contribution
€ 413 727
Address
It Centre Innovation Way
YO105NP York
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ECOLOGIC INSTITUT gemeinnützige GmbH
Germany
EU contribution
€ 172 586,25
Address
Pfalzburger Strasse 43-44
10717 Berlin
Activity type
Research Organisations
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Germany
EU contribution
€ 223 750
Address
Hansastrasse 27C
80686 Munchen
Activity type
Research Organisations
HELSINGIN YLIOPISTO
Finland
EU contribution
€ 243 771,25
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto
Activity type
Higher or Secondary Education Establishments
GOETEBORGS UNIVERSITET
Sweden
EU contribution
€ 226 250
Address
Vasaparken
405 30 Goeteborg
Activity type
Higher or Secondary Education Establishments
ASTRAZENECA AB
Sweden
EU contribution
€ 0
Address
Vastra Maelarhamnen
151 85 Sodertaelje
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD.
United Kingdom
EU contribution
€ 0
Address
Great West Road 980
TW89GS Brentford
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
F. HOFFMANN-LA ROCHE AG
Switzerland
EU contribution
€ 0
Address
Grenzacherstrasse 124
4070 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BAYER AKTIENGESELLSCHAFT
Germany
EU contribution
€ 0
Address
Kaiser-wilhelm-allee 1
51373 Leverkusen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BRISTOL-MYERS SQUIBB COMPANY CORP
United States
EU contribution
€ 0
Address
Park Avenue 345
10154 New York
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
NOVARTIS PHARMA AG
Switzerland
EU contribution
€ 0
Address
Lichtstrasse 35
4056 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT
France
EU contribution
€ 0
Address
Pierre Brossolette 1
91380 Chilly Mazarin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INSTITUT DE RECHERCHES INTERNATIONALES SERVIER
France
EU contribution
€ 0
Address
Rue Carnot 50
92284 Suresnes
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Eli Lilly and Company Limited
United Kingdom
EU contribution
€ 0
Address
Lilly House, Priestley Road
RG24 9NL Basingstoke
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
THE EUROPEAN MEDICINES AGENCY
Netherlands
EU contribution
€ 47 000
Address
Domenico Scarlattilaan 6
1083 HS Amsterdam
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
MERCK SHARP & DOHME CORP
United States
EU contribution
€ 0
Address
One Merck Drive
08889 Whitehouse Station Nj
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)