A Nanotechnology Based Blood Culture Medium to Detect Invasive Candida in Bloodstream

Projektinformationen

CandidaHunter

ID Finanzhilfevereinbarung: 877651

DOI

10.3030/877651

Projekt abgeschlossen

EK-Unterschriftsdatum 22 Juli 2019

Startdatum 1 August 2019

Enddatum 31 Januar 2020

Finanziert unter

• INDUSTRIAL LEADERSHIP - Innovation In SMEs

Gesamtkosten

€ 71 429,00

EU-Beitrag

€ 50 000,00

Koordiniert durch

MATRIKS BIYOTEKNOLOJI SANAYI VE TICARET LIMITED SIRKETI
Türkiye

Periodic Reporting for period 1 - CandidaHunter (A Nanotechnology Based Blood Culture Medium to Detect Invasive Candida in Bloodstream)

Berichtszeitraum: 2019-08-01 bis 2020-01-31

Zusammenfassung vom Kontext und den Gesamtzielen des Projekts

Candidiasis is the common name for diseases produced by the yeast of the genus Candida. This is the most frequently found yeast in human microbiome and can cause disease at different sites of the human anatomy with diverse severity. Invasive candidiasis refers to severe fungal infections in which the yeast might be found in deep organs or bloodstream. Despite advances in antifungal therapy, the mortality associated with invasive candidiasis remains as high as 40% which makes it the leading cause of mortality.
Fast diagnosis plays a crucial role in the outcome of these bloodstream infections and so, the prompt detection of bacteraemia and fungemia is a critical function of the clinical microbiology laboratory. The blood culture represents a critical tool for the detection of bloodstream infections.
There are many pathogenic Candida species. They can be found in the ground, animals, fruits and vegetables, and even in the hospital environment. In fact, invasive Candida infections are the 4th leading cause of hospital infections. The infection has a huge impact on life quality of patients and health care expenditures.
CandidaHunter is a nanotechnology-based blood culture medium where Matriks Biotek enhances the gold standard sensitivity up to 80% (where conventional blood cultures are 50%) and decreasing the 72 hours diagnosis period to 24 hours. CandidaHunter is a combination of culture-based and molecular technologies. With its molecular technology, CandidaHunter detects the deep-seated and disseminated diseases where conventional blood culture fails. In addition, it is planned to develop an alternative approach to Candida diagnosis without requiring mechanical equipment.

Arbeit, die ab Beginn des Projekts bis zum Ende des durch den Bericht erfassten Berichtszeitraums geleistet wurde, und die wichtigsten bis dahin erzielten Ergebnisse

First of all, the product requirement (CandidaHunter) was determined in the market. Then the need was confirmed by literature review and development steps were determined. In the next step, technical, infrastructure and financial requirements were determined and the search for resources started. In this context, Horizon2020 application has been made and accepted. After acceptance, a feasibility report is prepared.

Fortschritte, die über den aktuellen Stand der Technik hinausgehen und voraussichtliche potenzielle Auswirkungen (einschließlich der bis dato erzielten sozioökonomischen Auswirkungen und weiter gefassten gesellschaftlichen Auswirkungen des Projekts)

The product will be released to the market after the project is completed. With CandidaHunter, the diagnosis time for Candida infections will be shortened and the accuracy and rate of diagnosis will be increased. These gains will not only prevent patients from losing their lives, but will also reduce the length of hospital stay and the total money spent.

Timeline, past & future stages of CandidaHunter with TRL's