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Role of non-phagocytic, lymphocyte-like haemocytes in the antiviral and antibacterial defence of shrimp

Descripción del proyecto

Una mejor comprensión de la inmunidad natural del camarón blanco favorecerá la acuicultura sostenible

La demanda de camarones ha aumentado significativamente en los últimos veinte años. Según la Organización de las Naciones Unidas para la Agricultura y la Alimentación, la producción acuícola mundial de camarón blanco («Penaeus vannamei») pasó de unas ciento cincuenta mil toneladas en el año 2000 a más de cuatro millones de toneladas en 2016. Conforme aumenta la demanda, el control de enfermedades es cada vez más necesario para conseguir un cultivo de camarones satisfactorio. El sistema inmunitario del camarón blanco incluye cinco tipos de células sanguíneas (hematocitos). Dos de estos tipos de hematocitos se han descubierto recientemente y son similares a los linfocitos de mamíferos. El objetivo del proyecto financiado con fondos europeos ShrimpLLH es proporcionar información sobre la naturaleza y la función de estas células en la inmunidad del camarón blanco. Una mejor comprensión de su función servirá para aprovechar su capacidad natural para ayudar a los camarones blancos a defenderse de patógenos nocivos para lograr una acuicultura sostenible de estos sabrosos crustáceos.

Objetivo

Shrimp (Penaeus vannamei) aquaculture industry is the fastest-growing sector of the global aquaculture is threatened worldwide by viral diseases, of which White Spot Syndrome is the most harmful and bacterial diseases, of which Vibriosis is the most damaging. Therefore, appropriate biosecurity and management measures in shrimp aquaculture are important in preventing diseases. Stimulating the immunity in shrimp is another factor that can help shrimp in surviving infectious attacks. Although the immune system of invertebrates has been well studied in insects, much less information is currently available for crustaceans. The general concept in a crustacean is that there are three types of haemocytes in the circulating haemolymph, but recent research in the laboratory of Prof. Dr Hans Nauwynck indicated that the haemocytes of P. vannamei can be separated in five distinguished subpopulations, of which two subpopulations were previously not described. The cells of these two subpopulations resemble mammal lymphocytes and are therefore designated lymphocyte-like haemocytes (LLHs). Against this background, it is paramount to investigate the immunological function of these LLHs in depth. ShrimpLLH project objectives are (i) to isolate, (ii) to characterize and (iii) to analyze the immunological functions of haemocyte subpopulations. This project will further fill the knowledge gap in shrimp immunity, more specifically, it will provide information on the immunological role of LLHs. Since this project is multidisciplinary, it will increase the competence of the candidate in advanced immunological techniques and experience in crustacean innate immunity research. The new knowledge gained in this project will facilitate to develop a technique to screen products that can aid the shrimp haemocytes in their fight against different infectious diseases. ShrimpLLH project is in line with the EU strategy for the development of sustainable aquaculture.

Coordinador

UNIVERSITEIT GENT
Aportación neta de la UEn
€ 178 320,00
Dirección
SINT PIETERSNIEUWSTRAAT 25
9000 Gent
Bélgica

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Región
Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent
Tipo de actividad
Higher or Secondary Education Establishments
Enlaces
Coste total
€ 178 320,00