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Linking within-host and between-host evolution of multidrug-resistant Mycobacterium tuberculosis

Project description

Mycobacterium evolution within the host

Mycobacterium tuberculosis (Mtb) has been extensively characterised, but little is known about its evolution within the host. Scientists of the EU-funded ECOEVODRTB project will investigate the hypothesis that in short-sighted evolution there is a trade-off between virulence and transmission. This may be particularly relevant in the context of drug resistance. Therefore, researchers will determine the evolutionary forces and genomic characteristics of multidrug-resistant Mtb in individual patients and how they change over time. They will also develop an experimental approach for providing insight into the evolution of drug resistance with important consequences for tuberculosis treatment and overall public health.

Host institution

SCHWEIZERISCHES TROPEN UND PUBLIC HEALTH INSTITUT
Net EU contribution
€ 1 926 625,00
Address
Kreuzstrasse 2
4123 Allschwil
Switzerland

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Region
Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Landschaft
Activity type
Research Organisations
Non-EU contribution
€ 0,00

Beneficiaries (2)

SCHWEIZERISCHES TROPEN UND PUBLIC HEALTH INSTITUT
Switzerland
Net EU contribution
€ 1 926 625,00
Address
Kreuzstrasse 2
4123 Allschwil

See on map

Region
Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Landschaft
Activity type
Research Organisations
Non-EU contribution
€ 0,00
NATIONAL CENTER FOR TUBERCULOSIS AND LUNG DISEASES JSC
Georgia
Net EU contribution
€ 573 375,00
Address
8 Adjara
0101 Tbilisi

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00