Linking within-host and between-host evolution of multidrug-resistant Mycobacterium tuberculosis

Project Information

ECOEVODRTB

Grant agreement ID: 883582

DOI

10.3030/883582

EC signature date 24 July 2020

Start date 1 August 2020

End date 31 January 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 500 000,00

EU contribution

€ 2 500 000,00

Coordinated by

SCHWEIZERISCHES TROPEN UND PUBLIC HEALTH INSTITUT
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (17)

Phylogenomics of Mycobacterium africanum reveals a new lineage and a complex evolutionary history.

Author(s): Mireia Coscolla; Daniela Brites; Daniela Brites; Fabrizio Menardo; Fabrizio Menardo; Chloé Loiseau; Chloé Loiseau; Sonia Borrell; Sonia Borrell; Isaac Darko Otchere; Adwoa Asante-Poku; Prince Asare; Leonor Sánchez-Busó; Leonor Sánchez-Busó; Florian Gehre; C. N’Dira Sanoussi; Martin Antonio; Affolabi Dissou; Paula Ruiz-Rodríguez; Janet A. M. Fyfe; Erik C. Böttger; Patrick Becket; Stefan N
Published in: Microbial Genomics, Issue 2, 2021, ISSN 2057-5858
Publisher: Microbial Society
DOI: 10.17863/cam.64924

Expression Dysregulation as a Mediator of Fitness Costs in Antibiotic Resistance

Author(s): Trauner A, Banaei-Esfahani A, Gygli SM, Warmer P, Feldmann J, Zampieri M, Borrell S, Collins BC, Beisel C, Aebersold R, Gagneux S.
Published in: Antimicrob Agents Chemother, 2021, ISSN 0021-9193
Publisher: American Society for Microbiology
DOI: 10.1128/aac.00504-21

Effect of compensatory evolution in the emergence and transmission of rifampicin-resistant Mycobacterium tuberculosis in Cape Town, South Africa: a genomic epidemiology study

Author(s): Galo A Goig, Fabrizio Menardo, Zubeida Salaam-Dreyer, Anzaan Dippenaar, Elizabeth M Streicher, Johnny Daniels, Anja Reuter, Sonia Borrell, Miriam Reinhard, Anna Doetsch, Christian Beisel, Robin M Warren, Helen Cox, Sebastien Gagneux
Published in: The Lancet Microbe, Issue 4, 2023, Page(s) e506-e515, ISSN 2666-5247
Publisher: Elsevier
DOI: 10.1016/s2666-5247(23)00110-6

Mycobacterium tuberculosis complex lineage 5 exhibits high levels of within-lineage genomic diversity and differing gene content compared to the type strain H37Rv.

Author(s): C. N’Dira Sanoussi; C. N’Dira Sanoussi; Mireia Coscolla; Boatema Ofori-Anyinam; Isaac Darko Otchere; Martin Antonio; Stefan Niemann; Julian Parkhill; Julian Parkhill; Simon R. Harris; Dorothy Yeboah-Manu; Sebastien Gagneux; Sebastien Gagneux; Leen Rigouts; Leen Rigouts; Dissou Affolabi; Bouke C. de Jong; Conor J. Meehan; Conor J. Meehan
Published in: Microbial Genomics, Issue 2, 2021, ISSN 2057-5858
Publisher: Microbiology Society
DOI: 10.1099/mgen.0.000437

HIV co-infection is associated with reduced<i>Mycobacterium tuberculosis</i>transmissibility in sub-Saharan Africa

Author(s): Etthel M. Windels, Eddie M. Wampande, Moses L. Joloba, W. Henry Boom, Galo A. Goig, Helen Cox, Jerry Hella, Sonia Borrell, Sebastien Gagneux, Daniela Brites, Tanja Stadler
Published in: PLoS Pathogens, 2023, ISSN 1553-7374
Publisher: PLOS
DOI: 10.1101/2023.09.12.557301

Developing customized stepwise MIRU-VNTR typing for tuberculosis surveillance in Georgia

Author(s): Nino Maghradze; Levan Jugheli; Sonia Borrell; Nestani Tukvadze; Russell R. Kempker; Henry M. Blumberg; Sebastien Gagneux
Published in: PLoS One, Issue 1, 2022, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.5451/unibas-ep90637

Local adaptation in populations of Mycobacterium tuberculosis endemic to the Indian Ocean Rim

Author(s): Fabrizio Menardo; Fabrizio Menardo; Liliana K. Rutaihwa; Liliana K. Rutaihwa; Michaela Zwyer; Michaela Zwyer; Sonia Borrell; Sonia Borrell; Iñaki Comas; Emilyn Costa Conceição; Emilyn Costa Conceição; Mireia Coscolla; Helen Cox; Moses Joloba; Horng-Yunn Dou; Julia Feldmann; Julia Feldmann; Lukas Fenner; Lukas Fenner; Lukas Fenner; Janet A. M. Fyfe; Qian Gao; Darío García de Viedma; Alberto
Published in: F1000Research, Issue 1, 2021, ISSN 2046-1402
Publisher: F1000 Research Ltd.
DOI: 10.12688/f1000research.28318.2

Mortality from drug-resistant tuberculosis in high-burden countries comparing routine drug susceptibility testing with whole-genome sequencing: a multicentre cohort study

Author(s): Zürcher K, Reichmuth ML, Ballif M, Loiseau C, Borrell S, Reinhard M, Skrivankova V, Hömke R, Sander P, Avihingsanon A, Abimiku AG, Marcy O, Collantes J, Carter EJ, Wilkinson RJ, Cox H, Yotebieng M, Huebner R, Fenner L, Böttger EC, Gagneux S, Egger M.
Published in: Lancet Microbe, 2021, ISSN 0140-6736
Publisher: The Lancet Publishing Group
DOI: 10.1016/s2666-5247(21)00044-6

A new nomenclature for the livestock-associated Mycobacterium tuberculosis complex based on phylogenomics

Author(s): Michaela Zwyer; Cengiz Çavusoglu; Giovanni Ghielmetti; Maria Lodovica Pacciarini; Erika Scaltriti; Dick Van Soolingen; Anna Dötsch; Miriam Reinhard; Sebastien Gagneux; Daniela Brites
Published in: Open Research Europe, Issue 1, 2021, ISSN 2732-5121
Publisher: European Commission
DOI: 10.12688/openreseurope.14029.2

The within-host evolution of antimicrobial resistance in Mycobacterium tuberculosis.

Author(s): Rhastin A D Castro; Rhastin A D Castro; Sonia Borrell; Sonia Borrell; Sebastien Gagneux; Sebastien Gagneux
Published in: FEMS Microbiology Reviews, Issue 6, 2021, ISSN 0168-6445
Publisher: Blackwell
DOI: 10.1093/femsre/fuaa071

Using population-specific add-on polymorphisms to improve genotype imputation in underrepresented populations

Author(s): Zhi Ming Xu; Sina Rüeger; Michaela Zwyer; Daniela Brites; Hellen Hiza; Miriam Reinhard; Liliana Rutaihwa; Sonia Borrell; Faima Isihaka; Hosiana Temba; Thomas Maroa; Rastard Naftari; Jerry Hella; Mohamed Sasamalo; Klaus Reither; Damien Portevin; Sebastien Gagneux; Jacques Fellay
Published in: PLoS Computational Biology, Issue 1, 2022, Page(s) e1009628, ISSN 1553-734X
Publisher: Public Library of Science
DOI: 10.1371/journal.pcbi.1009628

Drug-induced differential culturability in diverse strains of Mycobacterium tuberculosis

Author(s): Valerie F. A. March, Nino Maghradze, Kakha Mchedlishvili, Teona Avaliani, Rusudan Aspindzelashvili, Zaza Avaliani, Maia Kipiani, Nestani Tukvadze, Levan Jugheli, Selim Bouaouina, Anna Doetsch, Galo A. Goig, Sebastien Gagneux, Sonia Borrell
Published in: Scientific Reports, Issue 15, 2025, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-024-85092-7

The relative transmission fitness of multidrug-resistant Mycobacterium tuberculosis in a drug resistance hotspot

Author(s): Chloé Loiseau, Etthel M. Windels, Sebastian M. Gygli, Levan Jugheli, Nino Maghradze, Daniela Brites, Amanda Ross, Galo Goig, Miriam Reinhard, Sonia Borrell, Andrej Trauner, Anna Dötsch, Rusudan Aspindzelashvili, Rebecca Denes, Klaus Reither, Christian Beisel, Nestani Tukvadze, Zaza Avaliani, Tanja Stadler, Sebastien Gagneux
Published in: Nature Communications, Issue 14, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-37719-y

Transmission as a Key Driver of Resistance to the New Tuberculosis Drugs

Author(s): Galo A. Goig, Chloé Loiseau, Nino Maghradze, Kakha Mchedlishvili, Teona Avaliani, Daniela Brites, Sonia Borrell, Rusudan Aspindzelashvili, Zaza Avaliani, Maia Kipiani, Nestani Tukvadze, Levan Jugheli, Sebastien Gagneux
Published in: New England Journal of Medicine, Issue 392, 2025, Page(s) 97-99, ISSN 0028-4793
Publisher: Massachusetts Medical Society
DOI: 10.1056/nejmc2404644

Back-to-Africa introductions of Mycobacterium tuberculosis as the main cause of tuberculosis in Dar es Salaam, Tanzania

Author(s): Michaela Zwyer, Liliana K. Rutaihwa, Etthel Windels, Jerry Hella, Fabrizio Menardo, Mohamed Sasamalo, Gregor Sommer, Lena Schmülling, Sonia Borrell, Miriam Reinhard, Anna Dötsch, Hellen Hiza, Christoph Stritt, George Sikalengo, Lukas Fenner, Bouke C. De Jong, Midori Kato-Maeda, Levan Jugheli, Joel D. Ernst, Stefan Niemann, Leila Jeljeli, Marie Ballif, Matthias Egger, Niaina Rakotosamimanana, Dor
Published in: PLOS Pathogens, Issue 19, 2023, Page(s) e1010893, ISSN 1553-7374
Publisher: PLOS
DOI: 10.1371/journal.ppat.1010893

Prisons as ecological drivers of fitness-compensated multidrug-resistant Mycobacterium tuberculosis

Author(s): Gygli SM, Loiseau C, Jugheli L, Adamia N, Trauner A, Reinhard M, Ross A, Borrell S, Aspindzelashvili R, Maghradze N, Reither K, Beisel C, Tukvadze N, Avaliani Z, Gagneux S
Published in: Nature Medicine, 2021, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-021-01358-x

How do monomorphic bacteria evolve? The Mycobacterium tuberculosis complex and the awkward population genetics of extreme clonality

Author(s): Sebastien Gagneux, Christoph Stritt
Published in: Peer Community In Evolutionary Biology, 2022, ISSN 2551-668X
Publisher: Peer Community In Evolutionary Biology
DOI: 10.32942/x2gw2p