Tracking DNA damage repair
DNA damage repair is paramount to maintaining genomic integrity and preventing cancer. Homologous recombination (HR) ensures the repair of double strand breaks in DNA through key intermediates known as Holliday junctions (HJ). The EU-funded HollidayTrack project will develop molecular tools for detecting and determining the dynamic properties of HJ structures in cells. It will address the impact of local chromatin structure on HJ migration and resolution as well as the role of HJs in telomere biology. Collectively, the project's results will advance our knowledge on the patterns and distributions of HJ formation and migration in different cancer cell types.
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