Overcoming chromatin restricted DNA access

Project Information

DNAccess

Grant agreement ID: 884664

DOI

10.3030/884664

EC signature date 15 October 2020

Start date 1 March 2021

End date 28 February 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 302 500,00

EU contribution

€ 2 302 500,00

Coordinated by

FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (7)

Generating specificity in genome regulation through transcription factor sensitivity to chromatin

Author(s): Luke Isbel, Ralph S. Grand & Dirk Schübeler
Published in: Nature Reviews Genetics, 2022, ISSN 1471-0056
Publisher: Nature Publishing Group
DOI: 10.1038/s41576-022-00512-6

Readout of histone methylation by Trim24 locally restricts chromatin opening by p53

Author(s): Luke Isbel, Murat Iskar, Sevi Durdu, Joscha Weiss, Ralph S. Grand, Eric Hietter-Pfeiffer, Zuzanna Kozicka, Alicia K. Michael, Lukas Burger, Nicolas H. Thomä & Dirk Schübeler
Published in: Nature Structural & Molecular Biology, 2023, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/s41594-023-01021-8

Cancer lineage-specific regulation of YAP responsive elements revealed through large-scale functional epigenomic screens

Author(s): Inês A. M. Barbosa, Rajaraman Gopalakrishnan, Samuele Mercan, Thanos P. Mourikis, Typhaine Martin, Simon Wengert, Caibin Sheng, Fei Ji, Rui Lopes, Judith Knehr, Marc Altorfer, Alicia Lindeman, Carsten Russ, Ulrike Naumann, Javad Golji, Kathleen Sprouffske, Louise Barys, Luca Tordella, Dirk Schübeler, Tobias Schmelzle & Giorgio G. Galli
Published in: Nature Communications, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-39527-w

Evidence that direct inhibition of transcription factor binding is the prevailing mode of gene and repeat repression by DNA methylation

Author(s): Sebastian Kaluscha, Silvia Domcke, Christiane Wirbelauer, Michael B Stadler, Sevi Durdu, Lukas Burger , Dirk Schübeler
Published in: Nature Genetics, 2022, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-022-01241-6

Cooperation between bHLH transcription factors and histones for DNA access

Author(s): Alicia K. Michael, Lisa Stoos, Priya Crosby, Nikolas Eggers, Xinyu Y. Nie, Kristina Makasheva, Martina Minnich, Kelly L. Healy, Joscha Weiss, Georg Kempf, Simone Cavadini, Lukas Kater, Jan Seebacher, Luca Vecchia, Deyasini Chakraborty, Luke Isbel, Ralph S. Grand, Florian Andersch, Jennifer L. Fribourgh, Dirk Schübeler, Johannes Zuber, Andrew C. Liu, Peter B. Becker, Beat Fierz, …Nicolas H. Thom
Published in: nature, 2023, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-023-06282-3

DNA sequence and chromatin modifiers cooperate to confer epigenetic bistability at imprinting control regions

Author(s): Stefan Butz, Nina Schmolka, Ino D. Karemaker, Rodrigo Villaseñor, Isabel Schwarz, Silvia Domcke, Esther C. H. Uijttewaal, Julian Jude, Florian Lienert, Arnaud R. Krebs, Nathalie P. de Wagenaar, Xue Bao, Johannes Zuber, Ulrich Elling, Dirk Schübeler & Tuncay Baubec
Published in: Nature Genetics, Issue 10614036, 2022, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-022-01210-z

ZFP462 safeguards neural lineage specification by targeting G9A/GLP-mediated heterochromatin to silence enhancers

Author(s): Ramesh Yelagandula, Karin Stecher, Maria Novatchkova, Luca Michetti, Georg Michlits, Jingkui Wang, Pablo Hofbauer, Gintautas Vainorius, Carina Pribitzer, Luke Isbel, Sasha Mendjan, Dirk Schübeler, Ulrich Elling, Julius Brennecke & Oliver Bell
Published in: Nature Cell Biology, 2023, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-022-01051-2