The advent of the Iron Age in cell death

Project Information

IRONDEATH

Grant agreement ID: 884754

DOI

10.3030/884754

EC signature date 18 May 2020

Start date 1 November 2020

End date 31 October 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 499 835,00

EU contribution

€ 2 499 835,00

Coordinated by

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (39)

Exploiting ferroptosis vulnerabilities in cancer

Author(s): Toshitaka Nakamura, Marcus Conrad
Published in: Nature Cell Biology, Issue 26, 2024, Page(s) 1407-1419, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-024-01425-8

A tangible method to assess native ferroptosis suppressor activity

Author(s): Toshitaka Nakamura, Junya Ito, André Santos Dias Mourão, Adam Wahida, Kiyotaka Nakagawa, Eikan Mishima, Marcus Conrad
Published in: Cell Reports Methods, Issue 4, 2024, Page(s) 100710, ISSN 2667-2375
Publisher: Elsevier BV
DOI: 10.1016/j.crmeth.2024.100710

A non-canonical vitamin K cycle is a potent ferroptosis suppressor

Author(s): Eikan Mishima, Junya Ito, Zijun Wu, Toshitaka Nakamura, Adam Wahida, Sebastian Doll, Wulf Tonnus, Palina Nepachalovich, Elke Eggenhofer, Maceler Aldrovandi, Bernhard Henkelmann, Ken-ichi Yamada, Jonas Wanninger, Omkar Zilka, Emiko Sato, Regina Feederle, Daniela Hass, Adriano Maida, André Santos Dias Mourão, Andreas Linkermann, Edward K. Geissler, Kiyotaka Nakagawa, Takaaki Abe, Maria Fedorova, B
Published in: Nature 608, 778–783 (2022), Issue 00280836, 2022, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-05022-3

Persister Cancer Cells: Iron Addiction and Vulnerability to Ferroptosis.

Author(s): Rodriguez, Raphaël, Stuart L. Schreiber, and Marcus Conrad.
Published in: Molecular Cell 82 (4): 728–40, 2022, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2021.12.001

Characterization of a Patient-Derived Variant of GPX4 for Precision Therapy.

Author(s): Liu, Hengrui, Forouhar, Farhad, Seibt, Tobias, Saneto, Russell, Wigby, Kristen, Friedman, Jennifer, Xia, Xin, Shchepinov, Mikhail S., Ramesh, Sanath Kumar, Conrad, Marcus, Stockwell, Brent R
Published in: Nature Chemical Biology 18 (1): 91–100, 2022, ISSN 1552-4469
Publisher: Nature Publishing Grooup
DOI: 10.1038/s41589-021-00915-2

PRDX6 dictates ferroptosis sensitivity by directing cellular selenium utilization

Author(s): Junya Ito, Toshitaka Nakamura, Takashi Toyama, Deng Chen, Carsten Berndt, Gereon Poschmann, André Santos Dias Mourão, Sebastian Doll, Mirai Suzuki, Weijia Zhang, Jiashuo Zheng, Dietrich Trümbach, Naoya Yamada, Koya Ono, Masana Yazaki, Yasutaka Kawai, Mieko Arisawa, Yusuke Ohsaki, Hitoshi Shirakawa, Adam Wahida, Bettina Proneth, Yoshiro Saito, Kiyotaka Nakagawa, Eikan Mishima, Marcus Conrad
Published in: Molecular Cell, Issue 84, 2025, Page(s) 4629-4644.e9, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2024.10.028

Platelet-Instructed SPP1+ Macrophages Drive Myofibroblast Activation in Fibrosis in a CXCL4-Dependent Manner.

Author(s): Konrad Hoeft, Gideon J.L. Schaefer, Hyojin Kim, David Schumacher, Tore Bleckwehl, Qingqing Long, Barbara Mara Klinkhammer, Fabian Peisker, Lars Koch, James Nagai, Maurice Halder, Susanne Ziegler, Elisa Liehn, Christoph Kuppe, Jennifer Kranz, Sylvia Menzel, Ivan Costa, Adam Wahida, Peter Boor, Rebekka K. Schneider, Sikander Hayat, Rafael Kramann
Published in: Cell Reports 42 (2): 112131, 2023, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2023.112131

Nutritional and Metabolic Control of Ferroptosis.

Author(s): Mishima, Eikan, and Marcus Conrad
Published in: Annual Review of Nutrition 42 (August): 275–309, 2022, ISSN 0199-9885
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-nutr-062320-114541

Ferroptosis in health and disease

Author(s): Carsten Berndt, Hamed Alborzinia, Vera Skafar Amen, Scott Ayton, Uladzimir Barayeu, Alexander Bartelt, Hülya Bayir, Christina M. Bebber, Kivanc Birsoy, Jan P. Böttcher, Simone Brabletz, Thomas Brabletz, Ashley R. Brown, Bernhard Brüne, Giorgia Bulli, Alix Bruneau, Quan Chen, Gina M. DeNicola, Tobias P. Dick, Ayelén Distéfano, Scott J. Dixon, Jan B. Engler, Julia Esser-von Bieren, Maria Fedoro
Published in: Redox Biology, Issue 75, 2024, Page(s) 103211, ISSN 2213-2317
Publisher: Elsevier BV
DOI: 10.1016/j.redox.2024.103211

The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD

Author(s): Gizem Günes Günsel; Thomas M. Conlon; Aicha Jeridi; Rinho Kim; Zeynep Ertüz; Niklas J. Lang; Meshal Ansari; Mariia Novikova; Dongsheng Jiang; Maximilian Strunz; Mariia Gaianova; Christine Hollauer; Christina Gabriel; Ilias Angelidis; Sebastian Doll; Jeanine C. Pestoni; Stephanie L. Edelmann; Marlene Sophia Kohlhepp; Adrien Guillot; Kevin Bassler; Hannelore P. Van Eeckhoutte; Özgecan Kayalar; N
Published in: Nature Communications, Issue 2, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-28809-4

The ferroptosis mediator ACSL4 fails to prevent disease progression in mouse models of MASLD

Author(s): Carolin Angendohr, Christiane Koppe, Diran Herebian, Anne T. Schneider, Leonie Keysberg, Michael T. Singer, Julian Gilljam, Matthias A. Dille, Johannes G. Bode, Sebastian Doll, Marcus Conrad, Mihael Vucur, Tom Luedde
Published in: Hepatology Communications, Issue 9, 2025, ISSN 2471-254X
Publisher: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1097/hc9.0000000000000684

Non-enzymatic lipid peroxidation initiated by photodynamic therapy drives a distinct ferroptosis-like cell death pathway

Author(s): Sufang Shui; Zenglu Zhao; Hao Wang; Marcus Conrad; Guoquan Liu
Published in: Redox Biology 45 (102056): 102056, Issue 1, 2021, ISSN 2213-2317
Publisher: Elsevier BV
DOI: 10.1016/j.redox.2021.102056

N-acetyl-l-cysteine averts ferroptosis by fostering glutathione peroxidase 4

Author(s): Jiashuo Zheng, Weijia Zhang, Junya Ito, Bernhard Henkelmann, Chenxi Xu, Eikan Mishima, Marcus Conrad
Published in: Cell Chemical Biology, Issue 32, 2025, Page(s) 767-775.e5, ISSN 2451-9456
Publisher: Elsevier BV
DOI: 10.1016/j.chembiol.2025.04.002

NFE2L1-mediated proteasome function protects from ferroptosis.

Author(s): Stefan Kotschi; Anna Jung; Nienke Willemsen; Anahita Ofoghi; Bettina Proneth; Marcus Conrad; Alexander Bartelt
Published in: Molecular Metabolism, Vol 57, Iss , Pp 101436-, Issue 2, 2022, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2022.101436

Integrated chemical and genetic screens unveil FSP1 mechanisms of ferroptosis regulation

Author(s): Toshitaka Nakamura, Eikan Mishima, Naoya Yamada, André Santos Dias Mourão, Dietrich Trümbach, Sebastian Doll, Jonas Wanninger, Elena Lytton, Peter Sennhenn, Thamara Nishida Xavier da Silva, José Pedro Friedmann Angeli, Michael Sattler, Bettina Proneth, Marcus Conrad
Published in: Nature Structural & Molecular Biology, Issue 30, 2023, Page(s) 1806-1815, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/s41594-023-01136-y

Glioblastoma Relapses Show Increased Markers of Vulnerability to Ferroptosis.

Author(s): Kram, Helena, Georg Prokop, Bernhard Haller, Jens Gempt, Yang Wu, Friederike Schmidt-Graf, Jürgen Schlegel, Marcus Conrad, and Friederike Liesche-Starnecker
Published in: Frontiers in Oncology 12 (April): 841418, 2022, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2022.841418

Intrinsic and Extrinsic Limitations to the Design and Optimization of Inhibitors of Lipid Peroxidation and Associated Cell Death

Author(s): Luke A. Farmer; Zijun Wu; Jia-Fei Poon; Omkar Zilka; Svenja M. Lorenz; Stephanie Huehn; Bettina Proneth; Marcus Conrad; Derek A. Pratt
Published in: J. Am. Chem. Soc. 144, 14706-14721, Issue 4, 2022, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.2c05252

Juggling with lipids, a game of Russian roulette.

Author(s): Maceler Aldrovandi; Maria Fedorova; Marcus Conrad
Published in: Trends in Endocrinology and Metabolism: TEM 32 (7): 463–73., Issue 3, 2021, ISSN 1043-2760
Publisher: Elsevier BV
DOI: 10.1016/j.tem.2021.04.012

Ferroptosis: when metabolism meets cell death

Author(s): Jiashuo Zheng, Marcus Conrad
Published in: Physiological Reviews, Issue 105, 2025, Page(s) 651-706, ISSN 0031-9333
Publisher: American Physiological Society
DOI: 10.1152/physrev.00031.2024

MALT1 inhibitor MI-2 induces ferroptosis by direct targeting of GPX4

Author(s): Eikan Mishima, Thomas J. O’Neill, Kai P. Hoefig, Deng Chen, Gesine Behrens, Bernhard Henkelmann, Junya Ito, Kiyotaka Nakagawa, Vigo Heissmeyer, Marcus Conrad, Daniel Krappmann
Published in: Proceedings of the National Academy of Sciences, Issue 122, 2025, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2507997122

The Metabolic Underpinnings of Ferroptosis.

Author(s): Zheng, Jiashuo, and Marcus Conrad
Published in: Cell Metabolism 32 (6): 920–37, 2020, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2020.10.011

Mechanisms controlling cellular and systemic iron homeostasis

Author(s): Bruno Galy, Marcus Conrad, Martina Muckenthaler
Published in: Nature Reviews Molecular Cell Biology, Issue 25, 2024, Page(s) 133-155, ISSN 1471-0072
Publisher: Nature Publishing Group
DOI: 10.1038/s41580-023-00648-1

Targeting Ferroptosis Protects against Experimental (Multi)Organ Dysfunction and Death.

Author(s): Van Coillie, Samya, Van San, Emily, Goetschalckx, Ines, Wiernicki, Bartosz, Mukhopadhyay, Banibrata, Tonnus, Wulf, Choi, Sze Men, Roelandt, Ria, Dumitrascu, Catalina, Lamberts, Ludwig, Dams, Geert, Weyts, Wannes, Huysentruyt, Jelle, Hassannia, Behrouz, Ingold, Irina, Lele, Suhas, Meyer, Evelyne, Berg, Maya, Seurinck, Ruth, Saeys, Yvan, Vermeulen, An, van Nuijs, Alexander L. N., Conrad, Marcus, Lin
Published in: Nature Communications 13 (1): 1046, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-28718-6

Fin56-Induced Ferroptosis Is Supported by Autophagy-Mediated GPX4 Degradation and Functions Synergistically with MTOR Inhibition to Kill Bladder Cancer Cells.

Author(s): Sun, Yadong, Berleth, Niklas, Wu, Wenxian, Schlütermann, David, Deitersen, Jana, Stuhldreier, Fabian, Berning, Lena, Friedrich, Annabelle, Akgün, Seda, Mendiburo, María José, Wesselborg, Sebastian, Conrad, Marcus, Berndt, Carsten, Stork, Björn
Published in: Cell Death & Disease 12 (11): 1028, 2021, ISSN 2041-4889
Publisher: Nature Publishing Group
DOI: 10.1038/s41419-021-04306-2

7-Dehydrocholesterol is an endogenous suppressor of ferroptosis

Author(s): Florencio Porto Freitas, Hamed Alborzinia, Ancély Ferreira dos Santos, Palina Nepachalovich, Lohans Pedrera, Omkar Zilka, Alex Inague, Corinna Klein, Nesrine Aroua, Kamini Kaushal, Bettina Kast, Svenja M. Lorenz, Viktoria Kunz, Helene Nehring, Thamara N. Xavier da Silva, Zhiyi Chen, Sena Atici, Sebastian G. Doll, Emily L. Schaefer, Ifedapo Ekpo, Werner Schmitz, Aline Horling, Peter Imming, Sayuri
Published in: Nature, Issue 626, 2024, Page(s) 401-410, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-023-06878-9

Missense Mutation in Selenocysteine Synthase Causes Cardio-Respiratory Failure and Perinatal Death in Mice Which Can Be Compensated by Selenium-Independent GPX4.

Author(s): Fradejas-Villar, Noelia, Wenchao Zhao, Uschi Reuter, Michael Doengi, Irina Ingold, Simon Bohleber, Marcus Conrad, and Ulrich Schweizer
Published in: Redox Biology 48 (102188): 102188., 2021, ISSN 2213-2317
Publisher: Elsevier BV
DOI: 10.1016/j.redox.2021.102188

STING orchestrates the neuronal inflammatory stress response in multiple sclerosis

Author(s): Marcel S. Woo, Christina Mayer, Lars Binkle-Ladisch, Jana K. Sonner, Sina C. Rosenkranz, Artem Shaposhnykov, Nicola Rothammer, Volodymyr Tsvilovskyy, Svenja M. Lorenz, Lukas Raich, Lukas C. Bal, Vanessa Vieira, Ingrid Wagner, Simone Bauer, Markus Glatzel, Marcus Conrad, Doron Merkler, Marc Freichel, Manuel A. Friese
Published in: Cell, Issue 187, 2024, Page(s) 4043-4060.e30, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2024.05.031

Recommendations for robust and reproducible research on ferroptosis

Author(s): Eikan Mishima, Toshitaka Nakamura, Sebastian Doll, Bettina Proneth, Maria Fedorova, Derek A. Pratt, José Pedro Friedmann Angeli, Scott J. Dixon, Adam Wahida, Marcus Conrad
Published in: Nature Reviews Molecular Cell Biology, 2025, ISSN 1471-0072
Publisher: Nature Publishing Group
DOI: 10.1038/s41580-025-00843-2

Activation of lysosomal iron triggers ferroptosis in cancer

Author(s): Tatiana Cañeque, Leeroy Baron, Sebastian Müller, Alanis Carmona, Ludovic Colombeau, Antoine Versini, Stéphanie Solier, Christine Gaillet, Fabien Sindikubwabo, Julio L. Sampaio, Marie Sabatier, Eikan Mishima, Armel Picard-Bernes, Laurène Syx, Nicolas Servant, Bérangère Lombard, Damarys Loew, Jiashuo Zheng, Bettina Proneth, Leishemba K. Thoidingjam, Laurence Grimaud, Cameron S. Fraser, Krystin
Published in: Nature, Issue 642, 2025, Page(s) 492-500, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-025-08974-4

LRP8‐mediated selenocysteine uptake is a targetable vulnerability in MYCN‐amplified neuroblastoma

Author(s): Hamed Alborzinia, Zhiyi Chen, Umut Yildiz, Florencio Porto Freitas, Felix C E Vogel, Julianna Patricia Varga, Jasmin Batani, Christoph Bartenhagen, Werner Schmitz, Gabriele Büchel, Bernhard Michalke, Jashuo Zheng, Svenja Meierjohann, Enrico Girardi, Elisa Espinet, Andrés F Flórez, Ancely Ferreira dos Santos, Nesrine Aroua, Tasneem Cheytan, Julie Haenlin, Lisa Schlicker, Thamara N Xavier da Silv
Published in: EMBO Molecular Medicine, Issue 15, 2023, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202318014

Non-Invasive and High-Throughput Interrogation of Exon-Specific Isoform Expression.

Author(s): Truong, Dong-Jiunn Jeffery, Phlairaharn, Teeradon, Eßwein, Bianca, Gruber, Christoph, Tümen, Deniz, Baligács, Enikő, Armbrust, Niklas, Vaccaro, Francesco Leandro, Lederer, Eva-Maria, Beck, Eva Magdalena, Geilenkeuser, Julian, Göppert, Simone, Krumwiede, Luisa, Grätz, Christian, Raffl, Gerald, Schwarz, Dominic, Zirngibl, Martin, Živanić, Milica, Beyer, Maren, Körner, Johann Dietmar, Santl,
Published in: Nature Cell Biology 23 (6): 652–63, 2021, ISSN 1476-4679
Publisher: Nature Publishing Grouep
DOI: 10.1038/s41556-021-00678-x

Dysfunction of the Key Ferroptosis-Surveilling Systems Hypersensitizes Mice to Tubular Necrosis during Acute Kidney Injury.

Author(s): Tonnus, Wulf, Meyer, Claudia, Steinebach, Christian, Belavgeni, Alexia, von Mässenhausen, Anne, Gonzalez, Nadia Zamora, Maremonti, Francesca, Gembardt, Florian, Himmerkus, Nina, Latk, Markus, Locke, Sophie, Marschner, Julian, Li, Wenjun, Short, Spencer, Doll, Sebastian, Ingold, Irina, Proneth, Bettina, Daniel, Christoph, Kabgani, Nazanin, Kramann, Rafael, Motika, Stephen, Hergenrother, Paul J., B
Published in: Nature Communications 12 (1): 4402., 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-24712-6

Interplay of ferroptotic and apoptotic cell death and its modulation by BH3-mimetics

Author(s): Yun Qiu, Juliana A. Hüther, Bianca Wank, Antonia Rath, René Tykwe, Maceler Aldrovandi, Bernhard Henkelmann, Julia Mergner, Toshitaka Nakamura, Sabine Laschat, Marcus Conrad, Daniela Stöhr, Markus Rehm
Published in: Cell Death & Differentiation, 2025, ISSN 1350-9047
Publisher: Nature Publishing Group
DOI: 10.1038/s41418-025-01514-7

Diverse Biological Functions of Vitamin K: From Coagulation to Ferroptosis.

Author(s): Mishima, Eikan, Adam Wahida, Tobias Seibt, and Marcus Conrad
Published in: Nature Metabolism 5 (6): 924–32, 2023, ISSN 2522-5812
Publisher: Nature Publishing Group
DOI: 10.1038/s42255-023-00821-y

Ferroptosis: Mechanisms, Biology and Role in Disease.

Author(s): Jiang, Xuejun, Brent R. Stockwell, and Marcus Conrad
Published in: Nature Reviews. Molecular Cell Biology 22 (4): 266–82., 2021, ISSN 1471-0080
Publisher: Nature Publishing Group
DOI: 10.1038/s41580-020-00324-8

Sorafenib Fails to Trigger Ferroptosis across a Wide Range of Cancer Cell Lines.

Author(s): Zheng, Jiashuo, Mami Sato, Eikan Mishima, Hideyo Sato, Bettina Proneth, and Marcus Conrad
Published in: Cell Death & Disease 12 (7): 698, 2021, ISSN 2041-4889
Publisher: Nature Publishing Group
DOI: 10.1038/s41419-021-03998-w

Embryonal Erythropoiesis and Aging Exploit Ferroptosis.

Author(s): Zheng, Hao, Li Jiang, Tsuyoshi Tsuduki, Marcus Conrad, and Shinya Toyokuni
Published in: Redox Biology 48 (102175): 102175, 2021, ISSN 2213-2317
Publisher: Elsevier BV
DOI: 10.1016/j.redox.2021.102175

Phase separation of FSP1 promotes ferroptosis

Author(s): Toshitaka Nakamura, Clara Hipp, André Santos Dias Mourão, Jan Borggräfe, Maceler Aldrovandi, Bernhard Henkelmann, Jonas Wanninger, Eikan Mishima, Elena Lytton, David Emler, Bettina Proneth, Michael Sattler, Marcus Conrad
Published in: Nature, Issue 619, 2023, Page(s) 371-377, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-023-06255-6

ALDH7A1 protects against ferroptosis by generating membrane NADH and regulating FSP1

Author(s): Jia-Shu Yang, Andrew J. Morris, Koki Kamizaki, Jianzhong Chen, Jillian Stark, William M. Oldham, Toshitaka Nakamura, Eikan Mishima, Joseph Loscalzo, Yasuhiro Minami, Marcus Conrad, Whitney S. Henry, Victor W. Hsu
Published in: Cell, Issue 188, 2025, Page(s) 2569-2585.e20, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2025.03.019