The advent of the Iron Age in cell death

Informazioni relative al progetto

IRONDEATH

ID dell’accordo di sovvenzione: 884754

DOI

10.3030/884754

Data della firma CE 18 Maggio 2020

Data di avvio 1 Novembre 2020

Data di completamento 31 Ottobre 2026

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 499 835,00

Contributo UE

€ 2 499 835,00

Coordinato da

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (39)

Exploiting ferroptosis vulnerabilities in cancer

Autori: Toshitaka Nakamura, Marcus Conrad
Pubblicato in: Nature Cell Biology, Numero 26, 2024, Pagina/e 1407-1419, ISSN 1465-7392
Editore: Nature Publishing Group
DOI: 10.1038/s41556-024-01425-8

A tangible method to assess native ferroptosis suppressor activity

Autori: Toshitaka Nakamura, Junya Ito, André Santos Dias Mourão, Adam Wahida, Kiyotaka Nakagawa, Eikan Mishima, Marcus Conrad
Pubblicato in: Cell Reports Methods, Numero 4, 2024, Pagina/e 100710, ISSN 2667-2375
Editore: Elsevier BV
DOI: 10.1016/j.crmeth.2024.100710

A non-canonical vitamin K cycle is a potent ferroptosis suppressor

Autori: Eikan Mishima, Junya Ito, Zijun Wu, Toshitaka Nakamura, Adam Wahida, Sebastian Doll, Wulf Tonnus, Palina Nepachalovich, Elke Eggenhofer, Maceler Aldrovandi, Bernhard Henkelmann, Ken-ichi Yamada, Jonas Wanninger, Omkar Zilka, Emiko Sato, Regina Feederle, Daniela Hass, Adriano Maida, André Santos Dias Mourão, Andreas Linkermann, Edward K. Geissler, Kiyotaka Nakagawa, Takaaki Abe, Maria Fedorova, B
Pubblicato in: Nature 608, 778–783 (2022), Numero 00280836, 2022, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-022-05022-3

Persister Cancer Cells: Iron Addiction and Vulnerability to Ferroptosis.

Autori: Rodriguez, Raphaël, Stuart L. Schreiber, and Marcus Conrad.
Pubblicato in: Molecular Cell 82 (4): 728–40, 2022, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2021.12.001

Characterization of a Patient-Derived Variant of GPX4 for Precision Therapy.

Autori: Liu, Hengrui, Forouhar, Farhad, Seibt, Tobias, Saneto, Russell, Wigby, Kristen, Friedman, Jennifer, Xia, Xin, Shchepinov, Mikhail S., Ramesh, Sanath Kumar, Conrad, Marcus, Stockwell, Brent R
Pubblicato in: Nature Chemical Biology 18 (1): 91–100, 2022, ISSN 1552-4469
Editore: Nature Publishing Grooup
DOI: 10.1038/s41589-021-00915-2

PRDX6 dictates ferroptosis sensitivity by directing cellular selenium utilization

Autori: Junya Ito, Toshitaka Nakamura, Takashi Toyama, Deng Chen, Carsten Berndt, Gereon Poschmann, André Santos Dias Mourão, Sebastian Doll, Mirai Suzuki, Weijia Zhang, Jiashuo Zheng, Dietrich Trümbach, Naoya Yamada, Koya Ono, Masana Yazaki, Yasutaka Kawai, Mieko Arisawa, Yusuke Ohsaki, Hitoshi Shirakawa, Adam Wahida, Bettina Proneth, Yoshiro Saito, Kiyotaka Nakagawa, Eikan Mishima, Marcus Conrad
Pubblicato in: Molecular Cell, Numero 84, 2025, Pagina/e 4629-4644.e9, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2024.10.028

Platelet-Instructed SPP1+ Macrophages Drive Myofibroblast Activation in Fibrosis in a CXCL4-Dependent Manner.

Autori: Konrad Hoeft, Gideon J.L. Schaefer, Hyojin Kim, David Schumacher, Tore Bleckwehl, Qingqing Long, Barbara Mara Klinkhammer, Fabian Peisker, Lars Koch, James Nagai, Maurice Halder, Susanne Ziegler, Elisa Liehn, Christoph Kuppe, Jennifer Kranz, Sylvia Menzel, Ivan Costa, Adam Wahida, Peter Boor, Rebekka K. Schneider, Sikander Hayat, Rafael Kramann
Pubblicato in: Cell Reports 42 (2): 112131, 2023, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2023.112131

Nutritional and Metabolic Control of Ferroptosis.

Autori: Mishima, Eikan, and Marcus Conrad
Pubblicato in: Annual Review of Nutrition 42 (August): 275–309, 2022, ISSN 0199-9885
Editore: Annual Reviews, Inc.
DOI: 10.1146/annurev-nutr-062320-114541

Ferroptosis in health and disease

Autori: Carsten Berndt, Hamed Alborzinia, Vera Skafar Amen, Scott Ayton, Uladzimir Barayeu, Alexander Bartelt, Hülya Bayir, Christina M. Bebber, Kivanc Birsoy, Jan P. Böttcher, Simone Brabletz, Thomas Brabletz, Ashley R. Brown, Bernhard Brüne, Giorgia Bulli, Alix Bruneau, Quan Chen, Gina M. DeNicola, Tobias P. Dick, Ayelén Distéfano, Scott J. Dixon, Jan B. Engler, Julia Esser-von Bieren, Maria Fedoro
Pubblicato in: Redox Biology, Numero 75, 2024, Pagina/e 103211, ISSN 2213-2317
Editore: Elsevier BV
DOI: 10.1016/j.redox.2024.103211

The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD

Autori: Gizem Günes Günsel; Thomas M. Conlon; Aicha Jeridi; Rinho Kim; Zeynep Ertüz; Niklas J. Lang; Meshal Ansari; Mariia Novikova; Dongsheng Jiang; Maximilian Strunz; Mariia Gaianova; Christine Hollauer; Christina Gabriel; Ilias Angelidis; Sebastian Doll; Jeanine C. Pestoni; Stephanie L. Edelmann; Marlene Sophia Kohlhepp; Adrien Guillot; Kevin Bassler; Hannelore P. Van Eeckhoutte; Özgecan Kayalar; N
Pubblicato in: Nature Communications, Numero 2, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-28809-4

The ferroptosis mediator ACSL4 fails to prevent disease progression in mouse models of MASLD

Autori: Carolin Angendohr, Christiane Koppe, Diran Herebian, Anne T. Schneider, Leonie Keysberg, Michael T. Singer, Julian Gilljam, Matthias A. Dille, Johannes G. Bode, Sebastian Doll, Marcus Conrad, Mihael Vucur, Tom Luedde
Pubblicato in: Hepatology Communications, Numero 9, 2025, ISSN 2471-254X
Editore: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1097/hc9.0000000000000684

Non-enzymatic lipid peroxidation initiated by photodynamic therapy drives a distinct ferroptosis-like cell death pathway

Autori: Sufang Shui; Zenglu Zhao; Hao Wang; Marcus Conrad; Guoquan Liu
Pubblicato in: Redox Biology 45 (102056): 102056, Numero 1, 2021, ISSN 2213-2317
Editore: Elsevier BV
DOI: 10.1016/j.redox.2021.102056

N-acetyl-l-cysteine averts ferroptosis by fostering glutathione peroxidase 4

Autori: Jiashuo Zheng, Weijia Zhang, Junya Ito, Bernhard Henkelmann, Chenxi Xu, Eikan Mishima, Marcus Conrad
Pubblicato in: Cell Chemical Biology, Numero 32, 2025, Pagina/e 767-775.e5, ISSN 2451-9456
Editore: Elsevier BV
DOI: 10.1016/j.chembiol.2025.04.002

NFE2L1-mediated proteasome function protects from ferroptosis.

Autori: Stefan Kotschi; Anna Jung; Nienke Willemsen; Anahita Ofoghi; Bettina Proneth; Marcus Conrad; Alexander Bartelt
Pubblicato in: Molecular Metabolism, Vol 57, Iss , Pp 101436-, Numero 2, 2022, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2022.101436

Integrated chemical and genetic screens unveil FSP1 mechanisms of ferroptosis regulation

Autori: Toshitaka Nakamura, Eikan Mishima, Naoya Yamada, André Santos Dias Mourão, Dietrich Trümbach, Sebastian Doll, Jonas Wanninger, Elena Lytton, Peter Sennhenn, Thamara Nishida Xavier da Silva, José Pedro Friedmann Angeli, Michael Sattler, Bettina Proneth, Marcus Conrad
Pubblicato in: Nature Structural & Molecular Biology, Numero 30, 2023, Pagina/e 1806-1815, ISSN 1545-9993
Editore: Nature Publishing Group
DOI: 10.1038/s41594-023-01136-y

Glioblastoma Relapses Show Increased Markers of Vulnerability to Ferroptosis.

Autori: Kram, Helena, Georg Prokop, Bernhard Haller, Jens Gempt, Yang Wu, Friederike Schmidt-Graf, Jürgen Schlegel, Marcus Conrad, and Friederike Liesche-Starnecker
Pubblicato in: Frontiers in Oncology 12 (April): 841418, 2022, ISSN 2234-943X
Editore: Frontiers Media S. A.
DOI: 10.3389/fonc.2022.841418

Intrinsic and Extrinsic Limitations to the Design and Optimization of Inhibitors of Lipid Peroxidation and Associated Cell Death

Autori: Luke A. Farmer; Zijun Wu; Jia-Fei Poon; Omkar Zilka; Svenja M. Lorenz; Stephanie Huehn; Bettina Proneth; Marcus Conrad; Derek A. Pratt
Pubblicato in: J. Am. Chem. Soc. 144, 14706-14721, Numero 4, 2022, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.2c05252

Juggling with lipids, a game of Russian roulette.

Autori: Maceler Aldrovandi; Maria Fedorova; Marcus Conrad
Pubblicato in: Trends in Endocrinology and Metabolism: TEM 32 (7): 463–73., Numero 3, 2021, ISSN 1043-2760
Editore: Elsevier BV
DOI: 10.1016/j.tem.2021.04.012

Ferroptosis: when metabolism meets cell death

Autori: Jiashuo Zheng, Marcus Conrad
Pubblicato in: Physiological Reviews, Numero 105, 2025, Pagina/e 651-706, ISSN 0031-9333
Editore: American Physiological Society
DOI: 10.1152/physrev.00031.2024

MALT1 inhibitor MI-2 induces ferroptosis by direct targeting of GPX4

Autori: Eikan Mishima, Thomas J. O’Neill, Kai P. Hoefig, Deng Chen, Gesine Behrens, Bernhard Henkelmann, Junya Ito, Kiyotaka Nakagawa, Vigo Heissmeyer, Marcus Conrad, Daniel Krappmann
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 122, 2025, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2507997122

The Metabolic Underpinnings of Ferroptosis.

Autori: Zheng, Jiashuo, and Marcus Conrad
Pubblicato in: Cell Metabolism 32 (6): 920–37, 2020, ISSN 1550-4131
Editore: Cell Press
DOI: 10.1016/j.cmet.2020.10.011

Mechanisms controlling cellular and systemic iron homeostasis

Autori: Bruno Galy, Marcus Conrad, Martina Muckenthaler
Pubblicato in: Nature Reviews Molecular Cell Biology, Numero 25, 2024, Pagina/e 133-155, ISSN 1471-0072
Editore: Nature Publishing Group
DOI: 10.1038/s41580-023-00648-1

Targeting Ferroptosis Protects against Experimental (Multi)Organ Dysfunction and Death.

Autori: Van Coillie, Samya, Van San, Emily, Goetschalckx, Ines, Wiernicki, Bartosz, Mukhopadhyay, Banibrata, Tonnus, Wulf, Choi, Sze Men, Roelandt, Ria, Dumitrascu, Catalina, Lamberts, Ludwig, Dams, Geert, Weyts, Wannes, Huysentruyt, Jelle, Hassannia, Behrouz, Ingold, Irina, Lele, Suhas, Meyer, Evelyne, Berg, Maya, Seurinck, Ruth, Saeys, Yvan, Vermeulen, An, van Nuijs, Alexander L. N., Conrad, Marcus, Lin
Pubblicato in: Nature Communications 13 (1): 1046, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-28718-6

Fin56-Induced Ferroptosis Is Supported by Autophagy-Mediated GPX4 Degradation and Functions Synergistically with MTOR Inhibition to Kill Bladder Cancer Cells.

Autori: Sun, Yadong, Berleth, Niklas, Wu, Wenxian, Schlütermann, David, Deitersen, Jana, Stuhldreier, Fabian, Berning, Lena, Friedrich, Annabelle, Akgün, Seda, Mendiburo, María José, Wesselborg, Sebastian, Conrad, Marcus, Berndt, Carsten, Stork, Björn
Pubblicato in: Cell Death & Disease 12 (11): 1028, 2021, ISSN 2041-4889
Editore: Nature Publishing Group
DOI: 10.1038/s41419-021-04306-2

7-Dehydrocholesterol is an endogenous suppressor of ferroptosis

Autori: Florencio Porto Freitas, Hamed Alborzinia, Ancély Ferreira dos Santos, Palina Nepachalovich, Lohans Pedrera, Omkar Zilka, Alex Inague, Corinna Klein, Nesrine Aroua, Kamini Kaushal, Bettina Kast, Svenja M. Lorenz, Viktoria Kunz, Helene Nehring, Thamara N. Xavier da Silva, Zhiyi Chen, Sena Atici, Sebastian G. Doll, Emily L. Schaefer, Ifedapo Ekpo, Werner Schmitz, Aline Horling, Peter Imming, Sayuri
Pubblicato in: Nature, Numero 626, 2024, Pagina/e 401-410, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-023-06878-9

Missense Mutation in Selenocysteine Synthase Causes Cardio-Respiratory Failure and Perinatal Death in Mice Which Can Be Compensated by Selenium-Independent GPX4.

Autori: Fradejas-Villar, Noelia, Wenchao Zhao, Uschi Reuter, Michael Doengi, Irina Ingold, Simon Bohleber, Marcus Conrad, and Ulrich Schweizer
Pubblicato in: Redox Biology 48 (102188): 102188., 2021, ISSN 2213-2317
Editore: Elsevier BV
DOI: 10.1016/j.redox.2021.102188

STING orchestrates the neuronal inflammatory stress response in multiple sclerosis

Autori: Marcel S. Woo, Christina Mayer, Lars Binkle-Ladisch, Jana K. Sonner, Sina C. Rosenkranz, Artem Shaposhnykov, Nicola Rothammer, Volodymyr Tsvilovskyy, Svenja M. Lorenz, Lukas Raich, Lukas C. Bal, Vanessa Vieira, Ingrid Wagner, Simone Bauer, Markus Glatzel, Marcus Conrad, Doron Merkler, Marc Freichel, Manuel A. Friese
Pubblicato in: Cell, Numero 187, 2024, Pagina/e 4043-4060.e30, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2024.05.031

Recommendations for robust and reproducible research on ferroptosis

Autori: Eikan Mishima, Toshitaka Nakamura, Sebastian Doll, Bettina Proneth, Maria Fedorova, Derek A. Pratt, José Pedro Friedmann Angeli, Scott J. Dixon, Adam Wahida, Marcus Conrad
Pubblicato in: Nature Reviews Molecular Cell Biology, 2025, ISSN 1471-0072
Editore: Nature Publishing Group
DOI: 10.1038/s41580-025-00843-2

Activation of lysosomal iron triggers ferroptosis in cancer

Autori: Tatiana Cañeque, Leeroy Baron, Sebastian Müller, Alanis Carmona, Ludovic Colombeau, Antoine Versini, Stéphanie Solier, Christine Gaillet, Fabien Sindikubwabo, Julio L. Sampaio, Marie Sabatier, Eikan Mishima, Armel Picard-Bernes, Laurène Syx, Nicolas Servant, Bérangère Lombard, Damarys Loew, Jiashuo Zheng, Bettina Proneth, Leishemba K. Thoidingjam, Laurence Grimaud, Cameron S. Fraser, Krystin
Pubblicato in: Nature, Numero 642, 2025, Pagina/e 492-500, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-025-08974-4

LRP8‐mediated selenocysteine uptake is a targetable vulnerability in MYCN‐amplified neuroblastoma

Autori: Hamed Alborzinia, Zhiyi Chen, Umut Yildiz, Florencio Porto Freitas, Felix C E Vogel, Julianna Patricia Varga, Jasmin Batani, Christoph Bartenhagen, Werner Schmitz, Gabriele Büchel, Bernhard Michalke, Jashuo Zheng, Svenja Meierjohann, Enrico Girardi, Elisa Espinet, Andrés F Flórez, Ancely Ferreira dos Santos, Nesrine Aroua, Tasneem Cheytan, Julie Haenlin, Lisa Schlicker, Thamara N Xavier da Silv
Pubblicato in: EMBO Molecular Medicine, Numero 15, 2023, ISSN 1757-4676
Editore: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202318014

Non-Invasive and High-Throughput Interrogation of Exon-Specific Isoform Expression.

Autori: Truong, Dong-Jiunn Jeffery, Phlairaharn, Teeradon, Eßwein, Bianca, Gruber, Christoph, Tümen, Deniz, Baligács, Enikő, Armbrust, Niklas, Vaccaro, Francesco Leandro, Lederer, Eva-Maria, Beck, Eva Magdalena, Geilenkeuser, Julian, Göppert, Simone, Krumwiede, Luisa, Grätz, Christian, Raffl, Gerald, Schwarz, Dominic, Zirngibl, Martin, Živanić, Milica, Beyer, Maren, Körner, Johann Dietmar, Santl,
Pubblicato in: Nature Cell Biology 23 (6): 652–63, 2021, ISSN 1476-4679
Editore: Nature Publishing Grouep
DOI: 10.1038/s41556-021-00678-x

Dysfunction of the Key Ferroptosis-Surveilling Systems Hypersensitizes Mice to Tubular Necrosis during Acute Kidney Injury.

Autori: Tonnus, Wulf, Meyer, Claudia, Steinebach, Christian, Belavgeni, Alexia, von Mässenhausen, Anne, Gonzalez, Nadia Zamora, Maremonti, Francesca, Gembardt, Florian, Himmerkus, Nina, Latk, Markus, Locke, Sophie, Marschner, Julian, Li, Wenjun, Short, Spencer, Doll, Sebastian, Ingold, Irina, Proneth, Bettina, Daniel, Christoph, Kabgani, Nazanin, Kramann, Rafael, Motika, Stephen, Hergenrother, Paul J., B
Pubblicato in: Nature Communications 12 (1): 4402., 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-24712-6

Interplay of ferroptotic and apoptotic cell death and its modulation by BH3-mimetics

Autori: Yun Qiu, Juliana A. Hüther, Bianca Wank, Antonia Rath, René Tykwe, Maceler Aldrovandi, Bernhard Henkelmann, Julia Mergner, Toshitaka Nakamura, Sabine Laschat, Marcus Conrad, Daniela Stöhr, Markus Rehm
Pubblicato in: Cell Death & Differentiation, 2025, ISSN 1350-9047
Editore: Nature Publishing Group
DOI: 10.1038/s41418-025-01514-7

Diverse Biological Functions of Vitamin K: From Coagulation to Ferroptosis.

Autori: Mishima, Eikan, Adam Wahida, Tobias Seibt, and Marcus Conrad
Pubblicato in: Nature Metabolism 5 (6): 924–32, 2023, ISSN 2522-5812
Editore: Nature Publishing Group
DOI: 10.1038/s42255-023-00821-y

Ferroptosis: Mechanisms, Biology and Role in Disease.

Autori: Jiang, Xuejun, Brent R. Stockwell, and Marcus Conrad
Pubblicato in: Nature Reviews. Molecular Cell Biology 22 (4): 266–82., 2021, ISSN 1471-0080
Editore: Nature Publishing Group
DOI: 10.1038/s41580-020-00324-8

Sorafenib Fails to Trigger Ferroptosis across a Wide Range of Cancer Cell Lines.

Autori: Zheng, Jiashuo, Mami Sato, Eikan Mishima, Hideyo Sato, Bettina Proneth, and Marcus Conrad
Pubblicato in: Cell Death & Disease 12 (7): 698, 2021, ISSN 2041-4889
Editore: Nature Publishing Group
DOI: 10.1038/s41419-021-03998-w

Embryonal Erythropoiesis and Aging Exploit Ferroptosis.

Autori: Zheng, Hao, Li Jiang, Tsuyoshi Tsuduki, Marcus Conrad, and Shinya Toyokuni
Pubblicato in: Redox Biology 48 (102175): 102175, 2021, ISSN 2213-2317
Editore: Elsevier BV
DOI: 10.1016/j.redox.2021.102175

Phase separation of FSP1 promotes ferroptosis

Autori: Toshitaka Nakamura, Clara Hipp, André Santos Dias Mourão, Jan Borggräfe, Maceler Aldrovandi, Bernhard Henkelmann, Jonas Wanninger, Eikan Mishima, Elena Lytton, David Emler, Bettina Proneth, Michael Sattler, Marcus Conrad
Pubblicato in: Nature, Numero 619, 2023, Pagina/e 371-377, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-023-06255-6

ALDH7A1 protects against ferroptosis by generating membrane NADH and regulating FSP1

Autori: Jia-Shu Yang, Andrew J. Morris, Koki Kamizaki, Jianzhong Chen, Jillian Stark, William M. Oldham, Toshitaka Nakamura, Eikan Mishima, Joseph Loscalzo, Yasuhiro Minami, Marcus Conrad, Whitney S. Henry, Victor W. Hsu
Pubblicato in: Cell, Numero 188, 2025, Pagina/e 2569-2585.e20, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2025.03.019