The advent of the Iron Age in cell death

Publications

A non-canonical vitamin K cycle is a potent ferroptosis suppressor

Auteurs: Eikan Mishima, Junya Ito, Zijun Wu, Toshitaka Nakamura, Adam Wahida, Sebastian Doll, Wulf Tonnus, Palina Nepachalovich, Elke Eggenhofer, Maceler Aldrovandi, Bernhard Henkelmann, Ken-ichi Yamada, Jonas Wanninger, Omkar Zilka, Emiko Sato, Regina Feederle, Daniela Hass, Adriano Maida, André Santos Dias Mourão, Andreas Linkermann, Edward K. Geissler, Kiyotaka Nakagawa, Takaaki Abe, Maria Fedorova, B
Publié dans: Nature 608, 778–783 (2022), Numéro 00280836, 2022, ISSN 0028-0836
Éditeur: Nature Publishing Group
DOI: 10.1038/s41586-022-05022-3

Persister Cancer Cells: Iron Addiction and Vulnerability to Ferroptosis.

Auteurs: Rodriguez, Raphaël, Stuart L. Schreiber, and Marcus Conrad.
Publié dans: Molecular Cell 82 (4): 728–40, 2022, ISSN 1097-2765
Éditeur: Cell Press
DOI: 10.1016/j.molcel.2021.12.001

Characterization of a Patient-Derived Variant of GPX4 for Precision Therapy.

Auteurs: Liu, Hengrui, Forouhar, Farhad, Seibt, Tobias, Saneto, Russell, Wigby, Kristen, Friedman, Jennifer, Xia, Xin, Shchepinov, Mikhail S., Ramesh, Sanath Kumar, Conrad, Marcus, Stockwell, Brent R
Publié dans: Nature Chemical Biology 18 (1): 91–100, 2022, ISSN 1552-4469
Éditeur: Nature Publishing Grooup
DOI: 10.1038/s41589-021-00915-2

Platelet-Instructed SPP1+ Macrophages Drive Myofibroblast Activation in Fibrosis in a CXCL4-Dependent Manner.

Auteurs: Konrad Hoeft, Gideon J.L. Schaefer, Hyojin Kim, David Schumacher, Tore Bleckwehl, Qingqing Long, Barbara Mara Klinkhammer, Fabian Peisker, Lars Koch, James Nagai, Maurice Halder, Susanne Ziegler, Elisa Liehn, Christoph Kuppe, Jennifer Kranz, Sylvia Menzel, Ivan Costa, Adam Wahida, Peter Boor, Rebekka K. Schneider, Sikander Hayat, Rafael Kramann
Publié dans: Cell Reports 42 (2): 112131, 2023, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2023.112131

Nutritional and Metabolic Control of Ferroptosis.

Auteurs: Mishima, Eikan, and Marcus Conrad
Publié dans: Annual Review of Nutrition 42 (August): 275–309, 2022, ISSN 0199-9885
Éditeur: Annual Reviews, Inc.
DOI: 10.1146/annurev-nutr-062320-114541

The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD

Auteurs: Gizem Günes Günsel; Thomas M. Conlon; Aicha Jeridi; Rinho Kim; Zeynep Ertüz; Niklas J. Lang; Meshal Ansari; Mariia Novikova; Dongsheng Jiang; Maximilian Strunz; Mariia Gaianova; Christine Hollauer; Christina Gabriel; Ilias Angelidis; Sebastian Doll; Jeanine C. Pestoni; Stephanie L. Edelmann; Marlene Sophia Kohlhepp; Adrien Guillot; Kevin Bassler; Hannelore P. Van Eeckhoutte; Özgecan Kayalar; N
Publié dans: Nature Communications, Numéro 2, 2022, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-022-28809-4

Non-enzymatic lipid peroxidation initiated by photodynamic therapy drives a distinct ferroptosis-like cell death pathway

Auteurs: Sufang Shui; Zenglu Zhao; Hao Wang; Marcus Conrad; Guoquan Liu
Publié dans: Redox Biology 45 (102056): 102056, Numéro 1, 2021, ISSN 2213-2317
Éditeur: Elsevier BV
DOI: 10.1016/j.redox.2021.102056

NFE2L1-mediated proteasome function protects from ferroptosis.

Auteurs: Stefan Kotschi; Anna Jung; Nienke Willemsen; Anahita Ofoghi; Bettina Proneth; Marcus Conrad; Alexander Bartelt
Publié dans: Molecular Metabolism, Vol 57, Iss , Pp 101436-, Numéro 2, 2022, ISSN 2212-8778
Éditeur: Elsevier GmbH
DOI: 10.1016/j.molmet.2022.101436

Glioblastoma Relapses Show Increased Markers of Vulnerability to Ferroptosis.

Auteurs: Kram, Helena, Georg Prokop, Bernhard Haller, Jens Gempt, Yang Wu, Friederike Schmidt-Graf, Jürgen Schlegel, Marcus Conrad, and Friederike Liesche-Starnecker
Publié dans: Frontiers in Oncology 12 (April): 841418, 2022, ISSN 2234-943X
Éditeur: Frontiers Media S. A.
DOI: 10.3389/fonc.2022.841418

Intrinsic and Extrinsic Limitations to the Design and Optimization of Inhibitors of Lipid Peroxidation and Associated Cell Death

Auteurs: Luke A. Farmer; Zijun Wu; Jia-Fei Poon; Omkar Zilka; Svenja M. Lorenz; Stephanie Huehn; Bettina Proneth; Marcus Conrad; Derek A. Pratt
Publié dans: J. Am. Chem. Soc. 144, 14706-14721, Numéro 4, 2022, ISSN 0002-7863
Éditeur: American Chemical Society
DOI: 10.1021/jacs.2c05252

Juggling with lipids, a game of Russian roulette.

Auteurs: Maceler Aldrovandi; Maria Fedorova; Marcus Conrad
Publié dans: Trends in Endocrinology and Metabolism: TEM 32 (7): 463–73., Numéro 3, 2021, ISSN 1043-2760
Éditeur: Elsevier BV
DOI: 10.1016/j.tem.2021.04.012

The Metabolic Underpinnings of Ferroptosis.

Auteurs: Zheng, Jiashuo, and Marcus Conrad
Publié dans: Cell Metabolism 32 (6): 920–37, 2020, ISSN 1550-4131
Éditeur: Cell Press
DOI: 10.1016/j.cmet.2020.10.011

Targeting Ferroptosis Protects against Experimental (Multi)Organ Dysfunction and Death.

Auteurs: Van Coillie, Samya, Van San, Emily, Goetschalckx, Ines, Wiernicki, Bartosz, Mukhopadhyay, Banibrata, Tonnus, Wulf, Choi, Sze Men, Roelandt, Ria, Dumitrascu, Catalina, Lamberts, Ludwig, Dams, Geert, Weyts, Wannes, Huysentruyt, Jelle, Hassannia, Behrouz, Ingold, Irina, Lele, Suhas, Meyer, Evelyne, Berg, Maya, Seurinck, Ruth, Saeys, Yvan, Vermeulen, An, van Nuijs, Alexander L. N., Conrad, Marcus, Lin
Publié dans: Nature Communications 13 (1): 1046, 2022, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-022-28718-6

Fin56-Induced Ferroptosis Is Supported by Autophagy-Mediated GPX4 Degradation and Functions Synergistically with MTOR Inhibition to Kill Bladder Cancer Cells.

Auteurs: Sun, Yadong, Berleth, Niklas, Wu, Wenxian, Schlütermann, David, Deitersen, Jana, Stuhldreier, Fabian, Berning, Lena, Friedrich, Annabelle, Akgün, Seda, Mendiburo, María José, Wesselborg, Sebastian, Conrad, Marcus, Berndt, Carsten, Stork, Björn
Publié dans: Cell Death & Disease 12 (11): 1028, 2021, ISSN 2041-4889
Éditeur: Nature Publishing Group
DOI: 10.1038/s41419-021-04306-2

Missense Mutation in Selenocysteine Synthase Causes Cardio-Respiratory Failure and Perinatal Death in Mice Which Can Be Compensated by Selenium-Independent GPX4.

Auteurs: Fradejas-Villar, Noelia, Wenchao Zhao, Uschi Reuter, Michael Doengi, Irina Ingold, Simon Bohleber, Marcus Conrad, and Ulrich Schweizer
Publié dans: Redox Biology 48 (102188): 102188., 2021, ISSN 2213-2317
Éditeur: Elsevier BV
DOI: 10.1016/j.redox.2021.102188

Non-Invasive and High-Throughput Interrogation of Exon-Specific Isoform Expression.

Auteurs: Truong, Dong-Jiunn Jeffery, Phlairaharn, Teeradon, Eßwein, Bianca, Gruber, Christoph, Tümen, Deniz, Baligács, Enikő, Armbrust, Niklas, Vaccaro, Francesco Leandro, Lederer, Eva-Maria, Beck, Eva Magdalena, Geilenkeuser, Julian, Göppert, Simone, Krumwiede, Luisa, Grätz, Christian, Raffl, Gerald, Schwarz, Dominic, Zirngibl, Martin, Živanić, Milica, Beyer, Maren, Körner, Johann Dietmar, Santl,
Publié dans: Nature Cell Biology 23 (6): 652–63, 2021, ISSN 1476-4679
Éditeur: Nature Publishing Grouep
DOI: 10.1038/s41556-021-00678-x

Dysfunction of the Key Ferroptosis-Surveilling Systems Hypersensitizes Mice to Tubular Necrosis during Acute Kidney Injury.

Auteurs: Tonnus, Wulf, Meyer, Claudia, Steinebach, Christian, Belavgeni, Alexia, von Mässenhausen, Anne, Gonzalez, Nadia Zamora, Maremonti, Francesca, Gembardt, Florian, Himmerkus, Nina, Latk, Markus, Locke, Sophie, Marschner, Julian, Li, Wenjun, Short, Spencer, Doll, Sebastian, Ingold, Irina, Proneth, Bettina, Daniel, Christoph, Kabgani, Nazanin, Kramann, Rafael, Motika, Stephen, Hergenrother, Paul J., B
Publié dans: Nature Communications 12 (1): 4402., 2021, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-021-24712-6

Diverse Biological Functions of Vitamin K: From Coagulation to Ferroptosis.

Auteurs: Mishima, Eikan, Adam Wahida, Tobias Seibt, and Marcus Conrad
Publié dans: Nature Metabolism 5 (6): 924–32, 2023, ISSN 2522-5812
Éditeur: Nature Publishing Group
DOI: 10.1038/s42255-023-00821-y

Ferroptosis: Mechanisms, Biology and Role in Disease.

Auteurs: Jiang, Xuejun, Brent R. Stockwell, and Marcus Conrad
Publié dans: Nature Reviews. Molecular Cell Biology 22 (4): 266–82., 2021, ISSN 1471-0080
Éditeur: Nature Publishing Group
DOI: 10.1038/s41580-020-00324-8

Sorafenib Fails to Trigger Ferroptosis across a Wide Range of Cancer Cell Lines.

Auteurs: Zheng, Jiashuo, Mami Sato, Eikan Mishima, Hideyo Sato, Bettina Proneth, and Marcus Conrad
Publié dans: Cell Death & Disease 12 (7): 698, 2021, ISSN 2041-4889
Éditeur: Nature Publishing Group
DOI: 10.1038/s41419-021-03998-w

Embryonal Erythropoiesis and Aging Exploit Ferroptosis.

Auteurs: Zheng, Hao, Li Jiang, Tsuyoshi Tsuduki, Marcus Conrad, and Shinya Toyokuni
Publié dans: Redox Biology 48 (102175): 102175, 2021, ISSN 2213-2317
Éditeur: Elsevier BV
DOI: 10.1016/j.redox.2021.102175

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