The advent of the Iron Age in cell death

Información del proyecto

IRONDEATH

Identificador del acuerdo de subvención: 884754

DOI

10.3030/884754

Fecha de la firma de la CE 18 Mayo 2020

Fecha de inicio 1 Noviembre 2020

Fecha de finalización 31 Octubre 2026

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 499 835,00

Aportación de la UE

€ 2 499 835,00

Coordinado por

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (39)

Exploiting ferroptosis vulnerabilities in cancer

Autores: Toshitaka Nakamura, Marcus Conrad
Publicado en: Nature Cell Biology, Edición 26, 2024, Página(s) 1407-1419, ISSN 1465-7392
Editor: Nature Publishing Group
DOI: 10.1038/s41556-024-01425-8

A tangible method to assess native ferroptosis suppressor activity

Autores: Toshitaka Nakamura, Junya Ito, André Santos Dias Mourão, Adam Wahida, Kiyotaka Nakagawa, Eikan Mishima, Marcus Conrad
Publicado en: Cell Reports Methods, Edición 4, 2024, Página(s) 100710, ISSN 2667-2375
Editor: Elsevier BV
DOI: 10.1016/j.crmeth.2024.100710

A non-canonical vitamin K cycle is a potent ferroptosis suppressor

Autores: Eikan Mishima, Junya Ito, Zijun Wu, Toshitaka Nakamura, Adam Wahida, Sebastian Doll, Wulf Tonnus, Palina Nepachalovich, Elke Eggenhofer, Maceler Aldrovandi, Bernhard Henkelmann, Ken-ichi Yamada, Jonas Wanninger, Omkar Zilka, Emiko Sato, Regina Feederle, Daniela Hass, Adriano Maida, André Santos Dias Mourão, Andreas Linkermann, Edward K. Geissler, Kiyotaka Nakagawa, Takaaki Abe, Maria Fedorova, B
Publicado en: Nature 608, 778–783 (2022), Edición 00280836, 2022, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-022-05022-3

Persister Cancer Cells: Iron Addiction and Vulnerability to Ferroptosis.

Autores: Rodriguez, Raphaël, Stuart L. Schreiber, and Marcus Conrad.
Publicado en: Molecular Cell 82 (4): 728–40, 2022, ISSN 1097-2765
Editor: Cell Press
DOI: 10.1016/j.molcel.2021.12.001

Characterization of a Patient-Derived Variant of GPX4 for Precision Therapy.

Autores: Liu, Hengrui, Forouhar, Farhad, Seibt, Tobias, Saneto, Russell, Wigby, Kristen, Friedman, Jennifer, Xia, Xin, Shchepinov, Mikhail S., Ramesh, Sanath Kumar, Conrad, Marcus, Stockwell, Brent R
Publicado en: Nature Chemical Biology 18 (1): 91–100, 2022, ISSN 1552-4469
Editor: Nature Publishing Grooup
DOI: 10.1038/s41589-021-00915-2

PRDX6 dictates ferroptosis sensitivity by directing cellular selenium utilization

Autores: Junya Ito, Toshitaka Nakamura, Takashi Toyama, Deng Chen, Carsten Berndt, Gereon Poschmann, André Santos Dias Mourão, Sebastian Doll, Mirai Suzuki, Weijia Zhang, Jiashuo Zheng, Dietrich Trümbach, Naoya Yamada, Koya Ono, Masana Yazaki, Yasutaka Kawai, Mieko Arisawa, Yusuke Ohsaki, Hitoshi Shirakawa, Adam Wahida, Bettina Proneth, Yoshiro Saito, Kiyotaka Nakagawa, Eikan Mishima, Marcus Conrad
Publicado en: Molecular Cell, Edición 84, 2025, Página(s) 4629-4644.e9, ISSN 1097-2765
Editor: Cell Press
DOI: 10.1016/j.molcel.2024.10.028

Platelet-Instructed SPP1+ Macrophages Drive Myofibroblast Activation in Fibrosis in a CXCL4-Dependent Manner.

Autores: Konrad Hoeft, Gideon J.L. Schaefer, Hyojin Kim, David Schumacher, Tore Bleckwehl, Qingqing Long, Barbara Mara Klinkhammer, Fabian Peisker, Lars Koch, James Nagai, Maurice Halder, Susanne Ziegler, Elisa Liehn, Christoph Kuppe, Jennifer Kranz, Sylvia Menzel, Ivan Costa, Adam Wahida, Peter Boor, Rebekka K. Schneider, Sikander Hayat, Rafael Kramann
Publicado en: Cell Reports 42 (2): 112131, 2023, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2023.112131

Nutritional and Metabolic Control of Ferroptosis.

Autores: Mishima, Eikan, and Marcus Conrad
Publicado en: Annual Review of Nutrition 42 (August): 275–309, 2022, ISSN 0199-9885
Editor: Annual Reviews, Inc.
DOI: 10.1146/annurev-nutr-062320-114541

Ferroptosis in health and disease

Autores: Carsten Berndt, Hamed Alborzinia, Vera Skafar Amen, Scott Ayton, Uladzimir Barayeu, Alexander Bartelt, Hülya Bayir, Christina M. Bebber, Kivanc Birsoy, Jan P. Böttcher, Simone Brabletz, Thomas Brabletz, Ashley R. Brown, Bernhard Brüne, Giorgia Bulli, Alix Bruneau, Quan Chen, Gina M. DeNicola, Tobias P. Dick, Ayelén Distéfano, Scott J. Dixon, Jan B. Engler, Julia Esser-von Bieren, Maria Fedoro
Publicado en: Redox Biology, Edición 75, 2024, Página(s) 103211, ISSN 2213-2317
Editor: Elsevier BV
DOI: 10.1016/j.redox.2024.103211

The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD

Autores: Gizem Günes Günsel; Thomas M. Conlon; Aicha Jeridi; Rinho Kim; Zeynep Ertüz; Niklas J. Lang; Meshal Ansari; Mariia Novikova; Dongsheng Jiang; Maximilian Strunz; Mariia Gaianova; Christine Hollauer; Christina Gabriel; Ilias Angelidis; Sebastian Doll; Jeanine C. Pestoni; Stephanie L. Edelmann; Marlene Sophia Kohlhepp; Adrien Guillot; Kevin Bassler; Hannelore P. Van Eeckhoutte; Özgecan Kayalar; N
Publicado en: Nature Communications, Edición 2, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-28809-4

The ferroptosis mediator ACSL4 fails to prevent disease progression in mouse models of MASLD

Autores: Carolin Angendohr, Christiane Koppe, Diran Herebian, Anne T. Schneider, Leonie Keysberg, Michael T. Singer, Julian Gilljam, Matthias A. Dille, Johannes G. Bode, Sebastian Doll, Marcus Conrad, Mihael Vucur, Tom Luedde
Publicado en: Hepatology Communications, Edición 9, 2025, ISSN 2471-254X
Editor: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1097/hc9.0000000000000684

Non-enzymatic lipid peroxidation initiated by photodynamic therapy drives a distinct ferroptosis-like cell death pathway

Autores: Sufang Shui; Zenglu Zhao; Hao Wang; Marcus Conrad; Guoquan Liu
Publicado en: Redox Biology 45 (102056): 102056, Edición 1, 2021, ISSN 2213-2317
Editor: Elsevier BV
DOI: 10.1016/j.redox.2021.102056

N-acetyl-l-cysteine averts ferroptosis by fostering glutathione peroxidase 4

Autores: Jiashuo Zheng, Weijia Zhang, Junya Ito, Bernhard Henkelmann, Chenxi Xu, Eikan Mishima, Marcus Conrad
Publicado en: Cell Chemical Biology, Edición 32, 2025, Página(s) 767-775.e5, ISSN 2451-9456
Editor: Elsevier BV
DOI: 10.1016/j.chembiol.2025.04.002

NFE2L1-mediated proteasome function protects from ferroptosis.

Autores: Stefan Kotschi; Anna Jung; Nienke Willemsen; Anahita Ofoghi; Bettina Proneth; Marcus Conrad; Alexander Bartelt
Publicado en: Molecular Metabolism, Vol 57, Iss , Pp 101436-, Edición 2, 2022, ISSN 2212-8778
Editor: Elsevier GmbH
DOI: 10.1016/j.molmet.2022.101436

Integrated chemical and genetic screens unveil FSP1 mechanisms of ferroptosis regulation

Autores: Toshitaka Nakamura, Eikan Mishima, Naoya Yamada, André Santos Dias Mourão, Dietrich Trümbach, Sebastian Doll, Jonas Wanninger, Elena Lytton, Peter Sennhenn, Thamara Nishida Xavier da Silva, José Pedro Friedmann Angeli, Michael Sattler, Bettina Proneth, Marcus Conrad
Publicado en: Nature Structural & Molecular Biology, Edición 30, 2023, Página(s) 1806-1815, ISSN 1545-9993
Editor: Nature Publishing Group
DOI: 10.1038/s41594-023-01136-y

Glioblastoma Relapses Show Increased Markers of Vulnerability to Ferroptosis.

Autores: Kram, Helena, Georg Prokop, Bernhard Haller, Jens Gempt, Yang Wu, Friederike Schmidt-Graf, Jürgen Schlegel, Marcus Conrad, and Friederike Liesche-Starnecker
Publicado en: Frontiers in Oncology 12 (April): 841418, 2022, ISSN 2234-943X
Editor: Frontiers Media S. A.
DOI: 10.3389/fonc.2022.841418

Intrinsic and Extrinsic Limitations to the Design and Optimization of Inhibitors of Lipid Peroxidation and Associated Cell Death

Autores: Luke A. Farmer; Zijun Wu; Jia-Fei Poon; Omkar Zilka; Svenja M. Lorenz; Stephanie Huehn; Bettina Proneth; Marcus Conrad; Derek A. Pratt
Publicado en: J. Am. Chem. Soc. 144, 14706-14721, Edición 4, 2022, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.2c05252

Juggling with lipids, a game of Russian roulette.

Autores: Maceler Aldrovandi; Maria Fedorova; Marcus Conrad
Publicado en: Trends in Endocrinology and Metabolism: TEM 32 (7): 463–73., Edición 3, 2021, ISSN 1043-2760
Editor: Elsevier BV
DOI: 10.1016/j.tem.2021.04.012

Ferroptosis: when metabolism meets cell death

Autores: Jiashuo Zheng, Marcus Conrad
Publicado en: Physiological Reviews, Edición 105, 2025, Página(s) 651-706, ISSN 0031-9333
Editor: American Physiological Society
DOI: 10.1152/physrev.00031.2024

MALT1 inhibitor MI-2 induces ferroptosis by direct targeting of GPX4

Autores: Eikan Mishima, Thomas J. O’Neill, Kai P. Hoefig, Deng Chen, Gesine Behrens, Bernhard Henkelmann, Junya Ito, Kiyotaka Nakagawa, Vigo Heissmeyer, Marcus Conrad, Daniel Krappmann
Publicado en: Proceedings of the National Academy of Sciences, Edición 122, 2025, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2507997122

The Metabolic Underpinnings of Ferroptosis.

Autores: Zheng, Jiashuo, and Marcus Conrad
Publicado en: Cell Metabolism 32 (6): 920–37, 2020, ISSN 1550-4131
Editor: Cell Press
DOI: 10.1016/j.cmet.2020.10.011

Mechanisms controlling cellular and systemic iron homeostasis

Autores: Bruno Galy, Marcus Conrad, Martina Muckenthaler
Publicado en: Nature Reviews Molecular Cell Biology, Edición 25, 2024, Página(s) 133-155, ISSN 1471-0072
Editor: Nature Publishing Group
DOI: 10.1038/s41580-023-00648-1

Targeting Ferroptosis Protects against Experimental (Multi)Organ Dysfunction and Death.

Autores: Van Coillie, Samya, Van San, Emily, Goetschalckx, Ines, Wiernicki, Bartosz, Mukhopadhyay, Banibrata, Tonnus, Wulf, Choi, Sze Men, Roelandt, Ria, Dumitrascu, Catalina, Lamberts, Ludwig, Dams, Geert, Weyts, Wannes, Huysentruyt, Jelle, Hassannia, Behrouz, Ingold, Irina, Lele, Suhas, Meyer, Evelyne, Berg, Maya, Seurinck, Ruth, Saeys, Yvan, Vermeulen, An, van Nuijs, Alexander L. N., Conrad, Marcus, Lin
Publicado en: Nature Communications 13 (1): 1046, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-28718-6

Fin56-Induced Ferroptosis Is Supported by Autophagy-Mediated GPX4 Degradation and Functions Synergistically with MTOR Inhibition to Kill Bladder Cancer Cells.

Autores: Sun, Yadong, Berleth, Niklas, Wu, Wenxian, Schlütermann, David, Deitersen, Jana, Stuhldreier, Fabian, Berning, Lena, Friedrich, Annabelle, Akgün, Seda, Mendiburo, María José, Wesselborg, Sebastian, Conrad, Marcus, Berndt, Carsten, Stork, Björn
Publicado en: Cell Death & Disease 12 (11): 1028, 2021, ISSN 2041-4889
Editor: Nature Publishing Group
DOI: 10.1038/s41419-021-04306-2

7-Dehydrocholesterol is an endogenous suppressor of ferroptosis

Autores: Florencio Porto Freitas, Hamed Alborzinia, Ancély Ferreira dos Santos, Palina Nepachalovich, Lohans Pedrera, Omkar Zilka, Alex Inague, Corinna Klein, Nesrine Aroua, Kamini Kaushal, Bettina Kast, Svenja M. Lorenz, Viktoria Kunz, Helene Nehring, Thamara N. Xavier da Silva, Zhiyi Chen, Sena Atici, Sebastian G. Doll, Emily L. Schaefer, Ifedapo Ekpo, Werner Schmitz, Aline Horling, Peter Imming, Sayuri
Publicado en: Nature, Edición 626, 2024, Página(s) 401-410, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-023-06878-9

Missense Mutation in Selenocysteine Synthase Causes Cardio-Respiratory Failure and Perinatal Death in Mice Which Can Be Compensated by Selenium-Independent GPX4.

Autores: Fradejas-Villar, Noelia, Wenchao Zhao, Uschi Reuter, Michael Doengi, Irina Ingold, Simon Bohleber, Marcus Conrad, and Ulrich Schweizer
Publicado en: Redox Biology 48 (102188): 102188., 2021, ISSN 2213-2317
Editor: Elsevier BV
DOI: 10.1016/j.redox.2021.102188

STING orchestrates the neuronal inflammatory stress response in multiple sclerosis

Autores: Marcel S. Woo, Christina Mayer, Lars Binkle-Ladisch, Jana K. Sonner, Sina C. Rosenkranz, Artem Shaposhnykov, Nicola Rothammer, Volodymyr Tsvilovskyy, Svenja M. Lorenz, Lukas Raich, Lukas C. Bal, Vanessa Vieira, Ingrid Wagner, Simone Bauer, Markus Glatzel, Marcus Conrad, Doron Merkler, Marc Freichel, Manuel A. Friese
Publicado en: Cell, Edición 187, 2024, Página(s) 4043-4060.e30, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2024.05.031

Recommendations for robust and reproducible research on ferroptosis

Autores: Eikan Mishima, Toshitaka Nakamura, Sebastian Doll, Bettina Proneth, Maria Fedorova, Derek A. Pratt, José Pedro Friedmann Angeli, Scott J. Dixon, Adam Wahida, Marcus Conrad
Publicado en: Nature Reviews Molecular Cell Biology, 2025, ISSN 1471-0072
Editor: Nature Publishing Group
DOI: 10.1038/s41580-025-00843-2

Activation of lysosomal iron triggers ferroptosis in cancer

Autores: Tatiana Cañeque, Leeroy Baron, Sebastian Müller, Alanis Carmona, Ludovic Colombeau, Antoine Versini, Stéphanie Solier, Christine Gaillet, Fabien Sindikubwabo, Julio L. Sampaio, Marie Sabatier, Eikan Mishima, Armel Picard-Bernes, Laurène Syx, Nicolas Servant, Bérangère Lombard, Damarys Loew, Jiashuo Zheng, Bettina Proneth, Leishemba K. Thoidingjam, Laurence Grimaud, Cameron S. Fraser, Krystin
Publicado en: Nature, Edición 642, 2025, Página(s) 492-500, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-025-08974-4

LRP8‐mediated selenocysteine uptake is a targetable vulnerability in MYCN‐amplified neuroblastoma

Autores: Hamed Alborzinia, Zhiyi Chen, Umut Yildiz, Florencio Porto Freitas, Felix C E Vogel, Julianna Patricia Varga, Jasmin Batani, Christoph Bartenhagen, Werner Schmitz, Gabriele Büchel, Bernhard Michalke, Jashuo Zheng, Svenja Meierjohann, Enrico Girardi, Elisa Espinet, Andrés F Flórez, Ancely Ferreira dos Santos, Nesrine Aroua, Tasneem Cheytan, Julie Haenlin, Lisa Schlicker, Thamara N Xavier da Silv
Publicado en: EMBO Molecular Medicine, Edición 15, 2023, ISSN 1757-4676
Editor: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202318014

Non-Invasive and High-Throughput Interrogation of Exon-Specific Isoform Expression.

Autores: Truong, Dong-Jiunn Jeffery, Phlairaharn, Teeradon, Eßwein, Bianca, Gruber, Christoph, Tümen, Deniz, Baligács, Enikő, Armbrust, Niklas, Vaccaro, Francesco Leandro, Lederer, Eva-Maria, Beck, Eva Magdalena, Geilenkeuser, Julian, Göppert, Simone, Krumwiede, Luisa, Grätz, Christian, Raffl, Gerald, Schwarz, Dominic, Zirngibl, Martin, Živanić, Milica, Beyer, Maren, Körner, Johann Dietmar, Santl,
Publicado en: Nature Cell Biology 23 (6): 652–63, 2021, ISSN 1476-4679
Editor: Nature Publishing Grouep
DOI: 10.1038/s41556-021-00678-x

Dysfunction of the Key Ferroptosis-Surveilling Systems Hypersensitizes Mice to Tubular Necrosis during Acute Kidney Injury.

Autores: Tonnus, Wulf, Meyer, Claudia, Steinebach, Christian, Belavgeni, Alexia, von Mässenhausen, Anne, Gonzalez, Nadia Zamora, Maremonti, Francesca, Gembardt, Florian, Himmerkus, Nina, Latk, Markus, Locke, Sophie, Marschner, Julian, Li, Wenjun, Short, Spencer, Doll, Sebastian, Ingold, Irina, Proneth, Bettina, Daniel, Christoph, Kabgani, Nazanin, Kramann, Rafael, Motika, Stephen, Hergenrother, Paul J., B
Publicado en: Nature Communications 12 (1): 4402., 2021, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-24712-6

Interplay of ferroptotic and apoptotic cell death and its modulation by BH3-mimetics

Autores: Yun Qiu, Juliana A. Hüther, Bianca Wank, Antonia Rath, René Tykwe, Maceler Aldrovandi, Bernhard Henkelmann, Julia Mergner, Toshitaka Nakamura, Sabine Laschat, Marcus Conrad, Daniela Stöhr, Markus Rehm
Publicado en: Cell Death & Differentiation, 2025, ISSN 1350-9047
Editor: Nature Publishing Group
DOI: 10.1038/s41418-025-01514-7

Diverse Biological Functions of Vitamin K: From Coagulation to Ferroptosis.

Autores: Mishima, Eikan, Adam Wahida, Tobias Seibt, and Marcus Conrad
Publicado en: Nature Metabolism 5 (6): 924–32, 2023, ISSN 2522-5812
Editor: Nature Publishing Group
DOI: 10.1038/s42255-023-00821-y

Ferroptosis: Mechanisms, Biology and Role in Disease.

Autores: Jiang, Xuejun, Brent R. Stockwell, and Marcus Conrad
Publicado en: Nature Reviews. Molecular Cell Biology 22 (4): 266–82., 2021, ISSN 1471-0080
Editor: Nature Publishing Group
DOI: 10.1038/s41580-020-00324-8

Sorafenib Fails to Trigger Ferroptosis across a Wide Range of Cancer Cell Lines.

Autores: Zheng, Jiashuo, Mami Sato, Eikan Mishima, Hideyo Sato, Bettina Proneth, and Marcus Conrad
Publicado en: Cell Death & Disease 12 (7): 698, 2021, ISSN 2041-4889
Editor: Nature Publishing Group
DOI: 10.1038/s41419-021-03998-w

Embryonal Erythropoiesis and Aging Exploit Ferroptosis.

Autores: Zheng, Hao, Li Jiang, Tsuyoshi Tsuduki, Marcus Conrad, and Shinya Toyokuni
Publicado en: Redox Biology 48 (102175): 102175, 2021, ISSN 2213-2317
Editor: Elsevier BV
DOI: 10.1016/j.redox.2021.102175

Phase separation of FSP1 promotes ferroptosis

Autores: Toshitaka Nakamura, Clara Hipp, André Santos Dias Mourão, Jan Borggräfe, Maceler Aldrovandi, Bernhard Henkelmann, Jonas Wanninger, Eikan Mishima, Elena Lytton, David Emler, Bettina Proneth, Michael Sattler, Marcus Conrad
Publicado en: Nature, Edición 619, 2023, Página(s) 371-377, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-023-06255-6

ALDH7A1 protects against ferroptosis by generating membrane NADH and regulating FSP1

Autores: Jia-Shu Yang, Andrew J. Morris, Koki Kamizaki, Jianzhong Chen, Jillian Stark, William M. Oldham, Toshitaka Nakamura, Eikan Mishima, Joseph Loscalzo, Yasuhiro Minami, Marcus Conrad, Whitney S. Henry, Victor W. Hsu
Publicado en: Cell, Edición 188, 2025, Página(s) 2569-2585.e20, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2025.03.019