The advent of the Iron Age in cell death

Publicaciones

A non-canonical vitamin K cycle is a potent ferroptosis suppressor

Autores: Eikan Mishima, Junya Ito, Zijun Wu, Toshitaka Nakamura, Adam Wahida, Sebastian Doll, Wulf Tonnus, Palina Nepachalovich, Elke Eggenhofer, Maceler Aldrovandi, Bernhard Henkelmann, Ken-ichi Yamada, Jonas Wanninger, Omkar Zilka, Emiko Sato, Regina Feederle, Daniela Hass, Adriano Maida, André Santos Dias Mourão, Andreas Linkermann, Edward K. Geissler, Kiyotaka Nakagawa, Takaaki Abe, Maria Fedorova, B
Publicado en: Nature 608, 778–783 (2022), Edición 00280836, 2022, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-022-05022-3

Persister Cancer Cells: Iron Addiction and Vulnerability to Ferroptosis.

Autores: Rodriguez, Raphaël, Stuart L. Schreiber, and Marcus Conrad.
Publicado en: Molecular Cell 82 (4): 728–40, 2022, ISSN 1097-2765
Editor: Cell Press
DOI: 10.1016/j.molcel.2021.12.001

Characterization of a Patient-Derived Variant of GPX4 for Precision Therapy.

Autores: Liu, Hengrui, Forouhar, Farhad, Seibt, Tobias, Saneto, Russell, Wigby, Kristen, Friedman, Jennifer, Xia, Xin, Shchepinov, Mikhail S., Ramesh, Sanath Kumar, Conrad, Marcus, Stockwell, Brent R
Publicado en: Nature Chemical Biology 18 (1): 91–100, 2022, ISSN 1552-4469
Editor: Nature Publishing Grooup
DOI: 10.1038/s41589-021-00915-2

Platelet-Instructed SPP1+ Macrophages Drive Myofibroblast Activation in Fibrosis in a CXCL4-Dependent Manner.

Autores: Konrad Hoeft, Gideon J.L. Schaefer, Hyojin Kim, David Schumacher, Tore Bleckwehl, Qingqing Long, Barbara Mara Klinkhammer, Fabian Peisker, Lars Koch, James Nagai, Maurice Halder, Susanne Ziegler, Elisa Liehn, Christoph Kuppe, Jennifer Kranz, Sylvia Menzel, Ivan Costa, Adam Wahida, Peter Boor, Rebekka K. Schneider, Sikander Hayat, Rafael Kramann
Publicado en: Cell Reports 42 (2): 112131, 2023, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2023.112131

Nutritional and Metabolic Control of Ferroptosis.

Autores: Mishima, Eikan, and Marcus Conrad
Publicado en: Annual Review of Nutrition 42 (August): 275–309, 2022, ISSN 0199-9885
Editor: Annual Reviews, Inc.
DOI: 10.1146/annurev-nutr-062320-114541

The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD

Autores: Gizem Günes Günsel; Thomas M. Conlon; Aicha Jeridi; Rinho Kim; Zeynep Ertüz; Niklas J. Lang; Meshal Ansari; Mariia Novikova; Dongsheng Jiang; Maximilian Strunz; Mariia Gaianova; Christine Hollauer; Christina Gabriel; Ilias Angelidis; Sebastian Doll; Jeanine C. Pestoni; Stephanie L. Edelmann; Marlene Sophia Kohlhepp; Adrien Guillot; Kevin Bassler; Hannelore P. Van Eeckhoutte; Özgecan Kayalar; N
Publicado en: Nature Communications, Edición 2, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-28809-4

Non-enzymatic lipid peroxidation initiated by photodynamic therapy drives a distinct ferroptosis-like cell death pathway

Autores: Sufang Shui; Zenglu Zhao; Hao Wang; Marcus Conrad; Guoquan Liu
Publicado en: Redox Biology 45 (102056): 102056, Edición 1, 2021, ISSN 2213-2317
Editor: Elsevier BV
DOI: 10.1016/j.redox.2021.102056

NFE2L1-mediated proteasome function protects from ferroptosis.

Autores: Stefan Kotschi; Anna Jung; Nienke Willemsen; Anahita Ofoghi; Bettina Proneth; Marcus Conrad; Alexander Bartelt
Publicado en: Molecular Metabolism, Vol 57, Iss , Pp 101436-, Edición 2, 2022, ISSN 2212-8778
Editor: Elsevier GmbH
DOI: 10.1016/j.molmet.2022.101436

Glioblastoma Relapses Show Increased Markers of Vulnerability to Ferroptosis.

Autores: Kram, Helena, Georg Prokop, Bernhard Haller, Jens Gempt, Yang Wu, Friederike Schmidt-Graf, Jürgen Schlegel, Marcus Conrad, and Friederike Liesche-Starnecker
Publicado en: Frontiers in Oncology 12 (April): 841418, 2022, ISSN 2234-943X
Editor: Frontiers Media S. A.
DOI: 10.3389/fonc.2022.841418

Intrinsic and Extrinsic Limitations to the Design and Optimization of Inhibitors of Lipid Peroxidation and Associated Cell Death

Autores: Luke A. Farmer; Zijun Wu; Jia-Fei Poon; Omkar Zilka; Svenja M. Lorenz; Stephanie Huehn; Bettina Proneth; Marcus Conrad; Derek A. Pratt
Publicado en: J. Am. Chem. Soc. 144, 14706-14721, Edición 4, 2022, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.2c05252

Juggling with lipids, a game of Russian roulette.

Autores: Maceler Aldrovandi; Maria Fedorova; Marcus Conrad
Publicado en: Trends in Endocrinology and Metabolism: TEM 32 (7): 463–73., Edición 3, 2021, ISSN 1043-2760
Editor: Elsevier BV
DOI: 10.1016/j.tem.2021.04.012

The Metabolic Underpinnings of Ferroptosis.

Autores: Zheng, Jiashuo, and Marcus Conrad
Publicado en: Cell Metabolism 32 (6): 920–37, 2020, ISSN 1550-4131
Editor: Cell Press
DOI: 10.1016/j.cmet.2020.10.011

Targeting Ferroptosis Protects against Experimental (Multi)Organ Dysfunction and Death.

Autores: Van Coillie, Samya, Van San, Emily, Goetschalckx, Ines, Wiernicki, Bartosz, Mukhopadhyay, Banibrata, Tonnus, Wulf, Choi, Sze Men, Roelandt, Ria, Dumitrascu, Catalina, Lamberts, Ludwig, Dams, Geert, Weyts, Wannes, Huysentruyt, Jelle, Hassannia, Behrouz, Ingold, Irina, Lele, Suhas, Meyer, Evelyne, Berg, Maya, Seurinck, Ruth, Saeys, Yvan, Vermeulen, An, van Nuijs, Alexander L. N., Conrad, Marcus, Lin
Publicado en: Nature Communications 13 (1): 1046, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-28718-6

Fin56-Induced Ferroptosis Is Supported by Autophagy-Mediated GPX4 Degradation and Functions Synergistically with MTOR Inhibition to Kill Bladder Cancer Cells.

Autores: Sun, Yadong, Berleth, Niklas, Wu, Wenxian, Schlütermann, David, Deitersen, Jana, Stuhldreier, Fabian, Berning, Lena, Friedrich, Annabelle, Akgün, Seda, Mendiburo, María José, Wesselborg, Sebastian, Conrad, Marcus, Berndt, Carsten, Stork, Björn
Publicado en: Cell Death & Disease 12 (11): 1028, 2021, ISSN 2041-4889
Editor: Nature Publishing Group
DOI: 10.1038/s41419-021-04306-2

Missense Mutation in Selenocysteine Synthase Causes Cardio-Respiratory Failure and Perinatal Death in Mice Which Can Be Compensated by Selenium-Independent GPX4.

Autores: Fradejas-Villar, Noelia, Wenchao Zhao, Uschi Reuter, Michael Doengi, Irina Ingold, Simon Bohleber, Marcus Conrad, and Ulrich Schweizer
Publicado en: Redox Biology 48 (102188): 102188., 2021, ISSN 2213-2317
Editor: Elsevier BV
DOI: 10.1016/j.redox.2021.102188

Non-Invasive and High-Throughput Interrogation of Exon-Specific Isoform Expression.

Autores: Truong, Dong-Jiunn Jeffery, Phlairaharn, Teeradon, Eßwein, Bianca, Gruber, Christoph, Tümen, Deniz, Baligács, Enikő, Armbrust, Niklas, Vaccaro, Francesco Leandro, Lederer, Eva-Maria, Beck, Eva Magdalena, Geilenkeuser, Julian, Göppert, Simone, Krumwiede, Luisa, Grätz, Christian, Raffl, Gerald, Schwarz, Dominic, Zirngibl, Martin, Živanić, Milica, Beyer, Maren, Körner, Johann Dietmar, Santl,
Publicado en: Nature Cell Biology 23 (6): 652–63, 2021, ISSN 1476-4679
Editor: Nature Publishing Grouep
DOI: 10.1038/s41556-021-00678-x

Dysfunction of the Key Ferroptosis-Surveilling Systems Hypersensitizes Mice to Tubular Necrosis during Acute Kidney Injury.

Autores: Tonnus, Wulf, Meyer, Claudia, Steinebach, Christian, Belavgeni, Alexia, von Mässenhausen, Anne, Gonzalez, Nadia Zamora, Maremonti, Francesca, Gembardt, Florian, Himmerkus, Nina, Latk, Markus, Locke, Sophie, Marschner, Julian, Li, Wenjun, Short, Spencer, Doll, Sebastian, Ingold, Irina, Proneth, Bettina, Daniel, Christoph, Kabgani, Nazanin, Kramann, Rafael, Motika, Stephen, Hergenrother, Paul J., B
Publicado en: Nature Communications 12 (1): 4402., 2021, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-24712-6

Diverse Biological Functions of Vitamin K: From Coagulation to Ferroptosis.

Autores: Mishima, Eikan, Adam Wahida, Tobias Seibt, and Marcus Conrad
Publicado en: Nature Metabolism 5 (6): 924–32, 2023, ISSN 2522-5812
Editor: Nature Publishing Group
DOI: 10.1038/s42255-023-00821-y

Ferroptosis: Mechanisms, Biology and Role in Disease.

Autores: Jiang, Xuejun, Brent R. Stockwell, and Marcus Conrad
Publicado en: Nature Reviews. Molecular Cell Biology 22 (4): 266–82., 2021, ISSN 1471-0080
Editor: Nature Publishing Group
DOI: 10.1038/s41580-020-00324-8

Sorafenib Fails to Trigger Ferroptosis across a Wide Range of Cancer Cell Lines.

Autores: Zheng, Jiashuo, Mami Sato, Eikan Mishima, Hideyo Sato, Bettina Proneth, and Marcus Conrad
Publicado en: Cell Death & Disease 12 (7): 698, 2021, ISSN 2041-4889
Editor: Nature Publishing Group
DOI: 10.1038/s41419-021-03998-w

Embryonal Erythropoiesis and Aging Exploit Ferroptosis.

Autores: Zheng, Hao, Li Jiang, Tsuyoshi Tsuduki, Marcus Conrad, and Shinya Toyokuni
Publicado en: Redox Biology 48 (102175): 102175, 2021, ISSN 2213-2317
Editor: Elsevier BV
DOI: 10.1016/j.redox.2021.102175

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