MOVING FROM BIOMARKERS TO MECHANISM ORIENTED PREVENTION OF CARDIOMETABOLIC DISEASE

Project Information

PREVENT-2024

Grant agreement ID: 885003

DOI 10.3030/885003

EC signature date 18 November 2020

Start date 1 January 2021

End date 31 December 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 500 000,00

EU contribution € 2 500 000,00

Coordinated by

LUNDS UNIVERSITET
Sweden

Publications

Peer reviewed articles (14)

Metabolome-Defined Obesity and the Risk of Future Type 2 Diabetes and Mortality

Author(s): Ottosson F, Smith E, Ericson U, Brunkwall L, Orho-Melander M, Di Somma S, Antonini P, Nilsson PM, Fernandez C, Melander O
Published in: Diabetes Care, 2022, ISSN 0149-5992
Publisher: American Diabetes Association
DOI: 10.2337/dc21-2402

Effect of Monoclonal Antibody Blockade of Long Fragment Neurotensin on Weight Loss, Behavior, and Metabolic Traits After High-Fat Diet Induced Obesity

Author(s): Wu Z, Stadler N, Abbaci A, Liu J, Boullier A, Marie N, Biondi O, Moldes M, Morichon R, Feve B, Melander O, Forgez P
Published in: Frontiers in Endocrinology (Lausanne), 2021, ISSN 1664-2392
Publisher: Lausanne: Frontiers Media S.A., 2010-
DOI: 10.3389/fendo.2021.739287

Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes.

Author(s): Akbari P, Sosina OA, Bovijn J, Landheer K, Nielsen JB, Kim M, Aykul S, De T, Haas ME, Hindy G, Lin N, Dinsmore IR, Luo JZ, Hectors S, Geraghty B, Germino M, Panagis L, Parasoglou P, Walls JR, Halasz G, Atwal GS; Regeneron Genetics Center; DiscovEHR Collaboration, Jones M, LeBlanc MG, Still CD, Carey DJ, Giontella A, Orho-Melander M, Berumen J, Kuri-Morales P, Alegre-Díaz J, Torres JM, Emberson JR
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-32398-7

Clinical Evaluation of the Polygenetic Background of Blood Pressure in the Population-Based Setting

Author(s): Giontella A, Sjögren M, Lotta LA, Overton JD, Baras A, Regeneron Genetics Center, Minuz P, Fava C, Melander O
Published in: Hypertension (Dallas, Tex. : 1979), 2020, ISSN 0194-911X
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/hypertensionaha.120.15449

Novel insights into peptide amidation and amidating activity in the human circulation

Author(s): Kaufmann P, Bergmann A, Melander O
Published in: Scientific Reports, 2021, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-95305-y

A plasma lipid signature predicts incident coronary artery disease.

Author(s): Ottosson F, Emami Khoonsari P, Gerl MJ, Simons K, Melander O, Fernandez C.
Published in: International Journal of Cardiology, Issue 15, 2021, Page(s) 249-254, ISSN 0167-5273
Publisher: Elsevier BV
DOI: 10.1016/j.ijcard.2021.01.059

Genome-Wide Polygenic Score, Clinical Risk Factors, and Long-Term Trajectories of Coronary Artery Disease

Author(s): Hindy G, Aragam KG, Ng K, Chaffin M, Lotta LA, Baras A, Regeneron Genetics Center, Drake I, Orho-Melander M, Melander O, Kathiresan S, Khera AV
Published in: Arteriosclerosis, Thrombosis, and Vascular Biology, 2020, ISSN 1079-5642
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.120.314856

Lipidomic risk scores are independent of polygenic risk scores and can predict incidence of diabetes and cardiovascular disease in a large population cohort

Author(s): Lauber C, Gerl MJ, Klose C, Ottosson F, Melander O, Simons K
Published in: PLoS Biology, 2022, ISSN 1544-9173
Publisher: Public Library of Science
DOI: 10.1371/journal.pbio.3001561

Proteomic and Metabolomic Characterization of Metabolically Healthy Obesity: A Descriptive Study from a Swedish Cohort

Author(s): Korduner J, Nilsson PM, Melander O, Gerl MJ, Engström G, Bachus E, Magnusson M, Ottosson F
Published in: Journal of Obesity, 2021, ISSN 2090-0708
Publisher: Hindawi Publishing Corporation
DOI: 10.1155/2021/6616983

Comparison of cardiovascular disease and cancer prevalence between Mediterranean and north European middle-aged populations (The Cilento on Ageing Outcomes Study and The Malmö Offspring Study)

Author(s): Melander O, Antonini P, Ottosson F, Brunkwall L, Gallo W, Nilsson PM, Orho-Melander M, Pacente G, D'Arena G, Di Somma S
Published in: Internal and Emergency Medicine, 2021, ISSN 1828-0447
Publisher: CEPI-AIM Group
DOI: 10.1007/s11739-020-02625-4

Replication study reveals miR-483-5p as an important target in prevention of cardiometabolic disease

Author(s): Gallo W, Ottosson F, Kennbäck C, Jujic A, Esguerra JLS, Eliasson L, Melander O
Published in: BMC Cardiovascular Disorders, 2021, ISSN 1471-2261
Publisher: BioMed Central
DOI: 10.1186/s12872-021-01964-0

High pro-neurotensin levels in individuals with type 1 diabetes associate with the development of cardiovascular risk factors at follow-up.

Author(s): Cimini FA, Barchetta I, Bertoccini L, Ceccarelli V, Baroni MG, Melander O, Cavallo MG.
Published in: Acta Diabetologica, Issue 59, 2021, Page(s) 49-56, ISSN 0940-5429
Publisher: Springer Verlag
DOI: 10.1007/s00592-021-01783-x

Pro-Enkephalin and its association with renal function in Middle Eastern immigrants and native Swedes

Author(s): Nilsson C, Christensson A, Nilsson PM, Melander O, Bennet L
Published in: Scandinavian Journal of Clinical and Laboratory Investigation, 2021, ISSN 0036-5513
Publisher: Taylor & Francis
DOI: 10.1080/00365513.2021.1979243

A healthy dietary metabolic signature is associated with a lower risk for type 2 diabetes and coronary artery disease

Author(s): Smith E, Ericson U, Hellstrand S, Orho-Melander M, Nilsson PM, Fernandez C, Melander O, Ottosson F
Published in: BMC Medicine, 2022, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-022-02326-z