MOVING FROM BIOMARKERS TO MECHANISM ORIENTED PREVENTION OF CARDIOMETABOLIC DISEASE

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Metabolome-Defined Obesity and the Risk of Future Type 2 Diabetes and Mortality

Autoren: Ottosson F, Smith E, Ericson U, Brunkwall L, Orho-Melander M, Di Somma S, Antonini P, Nilsson PM, Fernandez C, Melander O
Veröffentlicht in: Diabetes Care, 2022, ISSN 0149-5992
Herausgeber: American Diabetes Association
DOI: 10.2337/dc21-2402

Effect of Monoclonal Antibody Blockade of Long Fragment Neurotensin on Weight Loss, Behavior, and Metabolic Traits After High-Fat Diet Induced Obesity

Autoren: Wu Z, Stadler N, Abbaci A, Liu J, Boullier A, Marie N, Biondi O, Moldes M, Morichon R, Feve B, Melander O, Forgez P
Veröffentlicht in: Frontiers in Endocrinology (Lausanne), 2021, ISSN 1664-2392
Herausgeber: Lausanne: Frontiers Media S.A., 2010-
DOI: 10.3389/fendo.2021.739287

Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes.

Autoren: Akbari P, Sosina OA, Bovijn J, Landheer K, Nielsen JB, Kim M, Aykul S, De T, Haas ME, Hindy G, Lin N, Dinsmore IR, Luo JZ, Hectors S, Geraghty B, Germino M, Panagis L, Parasoglou P, Walls JR, Halasz G, Atwal GS; Regeneron Genetics Center; DiscovEHR Collaboration, Jones M, LeBlanc MG, Still CD, Carey DJ, Giontella A, Orho-Melander M, Berumen J, Kuri-Morales P, Alegre-Díaz J, Torres JM, Emberson JR
Veröffentlicht in: Nature Communications, 2022, ISSN 2041-1723
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41467-022-32398-7

Clinical Evaluation of the Polygenetic Background of Blood Pressure in the Population-Based Setting

Autoren: Giontella A, Sjögren M, Lotta LA, Overton JD, Baras A, Regeneron Genetics Center, Minuz P, Fava C, Melander O
Veröffentlicht in: Hypertension (Dallas, Tex. : 1979), 2020, ISSN 0194-911X
Herausgeber: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/hypertensionaha.120.15449

Novel insights into peptide amidation and amidating activity in the human circulation

Autoren: Kaufmann P, Bergmann A, Melander O
Veröffentlicht in: Scientific Reports, 2021, ISSN 2045-2322
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41598-021-95305-y

A plasma lipid signature predicts incident coronary artery disease.

Autoren: Ottosson F, Emami Khoonsari P, Gerl MJ, Simons K, Melander O, Fernandez C.
Veröffentlicht in: International Journal of Cardiology, Ausgabe 15, 2021, Seite(n) 249-254, ISSN 0167-5273
Herausgeber: Elsevier BV
DOI: 10.1016/j.ijcard.2021.01.059

Genome-Wide Polygenic Score, Clinical Risk Factors, and Long-Term Trajectories of Coronary Artery Disease

Autoren: Hindy G, Aragam KG, Ng K, Chaffin M, Lotta LA, Baras A, Regeneron Genetics Center, Drake I, Orho-Melander M, Melander O, Kathiresan S, Khera AV
Veröffentlicht in: Arteriosclerosis, Thrombosis, and Vascular Biology, 2020, ISSN 1079-5642
Herausgeber: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.120.314856

Lipidomic risk scores are independent of polygenic risk scores and can predict incidence of diabetes and cardiovascular disease in a large population cohort

Autoren: Lauber C, Gerl MJ, Klose C, Ottosson F, Melander O, Simons K
Veröffentlicht in: PLoS Biology, 2022, ISSN 1544-9173
Herausgeber: Public Library of Science
DOI: 10.1371/journal.pbio.3001561

Proteomic and Metabolomic Characterization of Metabolically Healthy Obesity: A Descriptive Study from a Swedish Cohort

Autoren: Korduner J, Nilsson PM, Melander O, Gerl MJ, Engström G, Bachus E, Magnusson M, Ottosson F
Veröffentlicht in: Journal of Obesity, 2021, ISSN 2090-0708
Herausgeber: Hindawi Publishing Corporation
DOI: 10.1155/2021/6616983

Comparison of cardiovascular disease and cancer prevalence between Mediterranean and north European middle-aged populations (The Cilento on Ageing Outcomes Study and The Malmö Offspring Study)

Autoren: Melander O, Antonini P, Ottosson F, Brunkwall L, Gallo W, Nilsson PM, Orho-Melander M, Pacente G, D'Arena G, Di Somma S
Veröffentlicht in: Internal and Emergency Medicine, 2021, ISSN 1828-0447
Herausgeber: CEPI-AIM Group
DOI: 10.1007/s11739-020-02625-4

Replication study reveals miR-483-5p as an important target in prevention of cardiometabolic disease

Autoren: Gallo W, Ottosson F, Kennbäck C, Jujic A, Esguerra JLS, Eliasson L, Melander O
Veröffentlicht in: BMC Cardiovascular Disorders, 2021, ISSN 1471-2261
Herausgeber: BioMed Central
DOI: 10.1186/s12872-021-01964-0

High pro-neurotensin levels in individuals with type 1 diabetes associate with the development of cardiovascular risk factors at follow-up.

Autoren: Cimini FA, Barchetta I, Bertoccini L, Ceccarelli V, Baroni MG, Melander O, Cavallo MG.
Veröffentlicht in: Acta Diabetologica, Ausgabe 59, 2021, Seite(n) 49-56, ISSN 0940-5429
Herausgeber: Springer Verlag
DOI: 10.1007/s00592-021-01783-x

Pro-Enkephalin and its association with renal function in Middle Eastern immigrants and native Swedes

Autoren: Nilsson C, Christensson A, Nilsson PM, Melander O, Bennet L
Veröffentlicht in: Scandinavian Journal of Clinical and Laboratory Investigation, 2021, ISSN 0036-5513
Herausgeber: Taylor & Francis
DOI: 10.1080/00365513.2021.1979243

A healthy dietary metabolic signature is associated with a lower risk for type 2 diabetes and coronary artery disease

Autoren: Smith E, Ericson U, Hellstrand S, Orho-Melander M, Nilsson PM, Fernandez C, Melander O, Ottosson F
Veröffentlicht in: BMC Medicine, 2022, ISSN 1741-7015
Herausgeber: BioMed Central
DOI: 10.1186/s12916-022-02326-z

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