MOVING FROM BIOMARKERS TO MECHANISM ORIENTED PREVENTION OF CARDIOMETABOLIC DISEASE

Información del proyecto

PREVENT-2024

Identificador del acuerdo de subvención: 885003

DOI 10.3030/885003

Fecha de la firma de la CE 18 Noviembre 2020

Fecha de inicio 1 Enero 2021

Fecha de finalización 31 Diciembre 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total € 2 500 000,00

Aportación de la UE € 2 500 000,00

Coordinado por

LUNDS UNIVERSITET
Sweden

Publicaciones

Peer reviewed articles (14)

Metabolome-Defined Obesity and the Risk of Future Type 2 Diabetes and Mortality

Autores: Ottosson F, Smith E, Ericson U, Brunkwall L, Orho-Melander M, Di Somma S, Antonini P, Nilsson PM, Fernandez C, Melander O
Publicado en: Diabetes Care, 2022, ISSN 0149-5992
Editor: American Diabetes Association
DOI: 10.2337/dc21-2402

Effect of Monoclonal Antibody Blockade of Long Fragment Neurotensin on Weight Loss, Behavior, and Metabolic Traits After High-Fat Diet Induced Obesity

Autores: Wu Z, Stadler N, Abbaci A, Liu J, Boullier A, Marie N, Biondi O, Moldes M, Morichon R, Feve B, Melander O, Forgez P
Publicado en: Frontiers in Endocrinology (Lausanne), 2021, ISSN 1664-2392
Editor: Lausanne: Frontiers Media S.A., 2010-
DOI: 10.3389/fendo.2021.739287

Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes.

Autores: Akbari P, Sosina OA, Bovijn J, Landheer K, Nielsen JB, Kim M, Aykul S, De T, Haas ME, Hindy G, Lin N, Dinsmore IR, Luo JZ, Hectors S, Geraghty B, Germino M, Panagis L, Parasoglou P, Walls JR, Halasz G, Atwal GS; Regeneron Genetics Center; DiscovEHR Collaboration, Jones M, LeBlanc MG, Still CD, Carey DJ, Giontella A, Orho-Melander M, Berumen J, Kuri-Morales P, Alegre-Díaz J, Torres JM, Emberson JR
Publicado en: Nature Communications, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-32398-7

Clinical Evaluation of the Polygenetic Background of Blood Pressure in the Population-Based Setting

Autores: Giontella A, Sjögren M, Lotta LA, Overton JD, Baras A, Regeneron Genetics Center, Minuz P, Fava C, Melander O
Publicado en: Hypertension (Dallas, Tex. : 1979), 2020, ISSN 0194-911X
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/hypertensionaha.120.15449

Novel insights into peptide amidation and amidating activity in the human circulation

Autores: Kaufmann P, Bergmann A, Melander O
Publicado en: Scientific Reports, 2021, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-021-95305-y

A plasma lipid signature predicts incident coronary artery disease.

Autores: Ottosson F, Emami Khoonsari P, Gerl MJ, Simons K, Melander O, Fernandez C.
Publicado en: International Journal of Cardiology, Edición 15, 2021, Página(s) 249-254, ISSN 0167-5273
Editor: Elsevier BV
DOI: 10.1016/j.ijcard.2021.01.059

Genome-Wide Polygenic Score, Clinical Risk Factors, and Long-Term Trajectories of Coronary Artery Disease

Autores: Hindy G, Aragam KG, Ng K, Chaffin M, Lotta LA, Baras A, Regeneron Genetics Center, Drake I, Orho-Melander M, Melander O, Kathiresan S, Khera AV
Publicado en: Arteriosclerosis, Thrombosis, and Vascular Biology, 2020, ISSN 1079-5642
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.120.314856

Lipidomic risk scores are independent of polygenic risk scores and can predict incidence of diabetes and cardiovascular disease in a large population cohort

Autores: Lauber C, Gerl MJ, Klose C, Ottosson F, Melander O, Simons K
Publicado en: PLoS Biology, 2022, ISSN 1544-9173
Editor: Public Library of Science
DOI: 10.1371/journal.pbio.3001561

Proteomic and Metabolomic Characterization of Metabolically Healthy Obesity: A Descriptive Study from a Swedish Cohort

Autores: Korduner J, Nilsson PM, Melander O, Gerl MJ, Engström G, Bachus E, Magnusson M, Ottosson F
Publicado en: Journal of Obesity, 2021, ISSN 2090-0708
Editor: Hindawi Publishing Corporation
DOI: 10.1155/2021/6616983

Comparison of cardiovascular disease and cancer prevalence between Mediterranean and north European middle-aged populations (The Cilento on Ageing Outcomes Study and The Malmö Offspring Study)

Autores: Melander O, Antonini P, Ottosson F, Brunkwall L, Gallo W, Nilsson PM, Orho-Melander M, Pacente G, D'Arena G, Di Somma S
Publicado en: Internal and Emergency Medicine, 2021, ISSN 1828-0447
Editor: CEPI-AIM Group
DOI: 10.1007/s11739-020-02625-4

Replication study reveals miR-483-5p as an important target in prevention of cardiometabolic disease

Autores: Gallo W, Ottosson F, Kennbäck C, Jujic A, Esguerra JLS, Eliasson L, Melander O
Publicado en: BMC Cardiovascular Disorders, 2021, ISSN 1471-2261
Editor: BioMed Central
DOI: 10.1186/s12872-021-01964-0

High pro-neurotensin levels in individuals with type 1 diabetes associate with the development of cardiovascular risk factors at follow-up.

Autores: Cimini FA, Barchetta I, Bertoccini L, Ceccarelli V, Baroni MG, Melander O, Cavallo MG.
Publicado en: Acta Diabetologica, Edición 59, 2021, Página(s) 49-56, ISSN 0940-5429
Editor: Springer Verlag
DOI: 10.1007/s00592-021-01783-x

Pro-Enkephalin and its association with renal function in Middle Eastern immigrants and native Swedes

Autores: Nilsson C, Christensson A, Nilsson PM, Melander O, Bennet L
Publicado en: Scandinavian Journal of Clinical and Laboratory Investigation, 2021, ISSN 0036-5513
Editor: Taylor & Francis
DOI: 10.1080/00365513.2021.1979243

A healthy dietary metabolic signature is associated with a lower risk for type 2 diabetes and coronary artery disease

Autores: Smith E, Ericson U, Hellstrand S, Orho-Melander M, Nilsson PM, Fernandez C, Melander O, Ottosson F
Publicado en: BMC Medicine, 2022, ISSN 1741-7015
Editor: BioMed Central
DOI: 10.1186/s12916-022-02326-z