Descrizione del progetto
Inquinamento atmosferico prenatale, salute mentale materna e neurosviluppo della prole
Durante lo sviluppo prenatale, il feto è vulnerabile agli effetti di una serie di esposizioni ambientali, come stress, ansia e depressione materni. Questi possono avere effetti duraturi sullo sviluppo infantile con conseguenze per il rischio di psicopatologia o modifiche nelle strutture cerebrali associate a disturbo da deficit di attenzione/iperattività e disturbo dello spettro autistico. Il progetto PRESSURE, finanziato dall’UE, approfondirà gli effetti dell’inquinamento atmosferico e acustico nella depressione e nell’ansia prenatali materne. Valuterà il ruolo di mediazione della depressione/ansia materna nel legame tra inquinamento atmosferico e sviluppo di strutture cerebrali nel feto. In particolare, offrirà informazioni aggiuntive sui campi di valutazione dell’esposizione e sul modo in cui lo sviluppo cerebrale è influenzato dall’inquinamento atmosferico, il principale rischio ambientale urbano.
Obiettivo
Latest research suggests a link between air pollution (AP) and psychological health, including depression and impaired neurodevelopment. In pregnant women, besides mother’s own well-being, antenatal anxiety or depression may result in an abnormal brain development of the offspring generation. However, little evidence is yet available on these fields. Traditionally, epidemiological studies have used modelled ambient AP estimates at home, with biases arising from this simplification. Personal measurements of AP permit the determination of accurate exposure and dose, by considering different environments and physical activity intensities. Moreover, previous studies lack the assessment of possible confounding by noise on the effects of AP. The aims of the PRESSURE Project are to assess the effect of air pollution and noise in mother’s antenatal depression and anxiety and to evaluate the mediation role of mother’s depression/anxiety in the link between AP and the development of brain structures in the foetus. To achieve this aim, (i) I will develop a modelling framework to accurately quantify the exposure and dose of the population to PM2.5 Black Carbon (BC), and NO2 in different time-windows of the pregnancy period by using data from personal measurements in a large cohort of pregnant women (n=1,300); (ii) I will assess the effect of AP and noise exposure/dose on antenatal depression and anxiety (evaluated through questionnaires); and (iii) I will evaluate the mediation role of antenatal anxiety/depression in the association between maternal exposure to AP and structural changes in the growing brain of the foetuses and new-borns through neuroimaging (transvaginal neurosonography and neonatal MRI). This multidisciplinary project may add insight in the fields of exposure assessment and AP effects on mental health and brain development, and may lead to public health actions to improve air quality and reduce the burden of disease associated with air pollution in Europe.
Campo scientifico
Parole chiave
Programma(i)
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Meccanismo di finanziamento
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)Coordinatore
08036 Barcelona
Spagna