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Design study of an innovative high-intensity industrial cyclotron for production of Tc-99m and other frontier medical radioisotopes

Projektbeschreibung

Designstudie: Ringbeschleuniger mit hoher Intensität zur Herstellung medizinischer Radioisotope

Technetium-99m (99mTc) ist ein metastabiles Radioisotop, das bei zahllosen medizinischen Diagnoseverfahren genutzt wird. Heute wird es weltweit fast nur noch in einigen wenigen langsam veraltenden Forschungsreaktoren erzeugt. Radioaktive Arzneimittel, die auf 99mTc basieren, kommen bei der Bildgebung sowie bei funktionellen Studien von Gehirn, Herzmuskel, Schilddrüse, Lungen, Leber, Gallenblase, Nieren, Knochen, Blut sowie mehreren Tumoren zum Einsatz. Je nach angewandtem Verfahren ist das 99mTc an eine Verbindung gebunden, die es zur Wirkungsstelle transportiert. Um die Verfügbarkeit von 99mTc zu verbessern, ist die direkte Erzeugung im Ringbeschleuniger der vielversprechendste Ansatz. Doch die größte Herausforderung liegt darin, einen kompakten Apparat für hohe Intensitäten zu entwerfen, der zum Strahlentransfer keinen Deflektor benötigt. Ausgehend von neuen technologischen Lösungen wird das EU-finanzierte Projekt InnovaTron das Design des magnetischen Feldes und der Strahlenoptik des Ringbeschleunigers weiter optimieren.

Ziel

Tc99m is the most widely used isotope in nuclear medicine. Production is almost exclusively done with a few ageing research reactors worldwide. Recent shutdowns of some those reactors have resulted in a worldwide Tc99m shortage. Europe is affected, because it is the second largest consumer of Tc99m worldwide. In response to growing concerns about Tc99m availability and the increasing demand in medicine, alternative production routes are being explored in the community. Direct production by proton cyclotrons looks the most promising solution. Cyclotrons offer several advantages, one of them being the possibility for local production, as is done for other commonly used medical isotopes. Large-scale production of Tc99m requires high proton beam intensities. InnovaTron focuses on a cutting-edge research project in accelerator design. The key challenge is the design of an innovative compact high-intensity cyclotron, named ‘self-extracting cyclotron’. In this machine, the proton beams exit without using an extraction device. Such devices usually prevent the extraction of high beam currents as would be needed for Tc99m production. A prototype machine was built by the company IBA around the year 2000. Self-extraction was successfully proven by extracting a current close to 2 mA. However, rather poor beam quality was observed resulting in too high machine activation and a maximum extraction efficiency not larger than 80%. This was encouraging but not yet good enough for industrial applications. InnovaTron will improve the magnet design and the beam-optics of the self-extracting cyclotron based on new technological solutions. It will be realized using high-level computer-aided design and beam physics studies. Key goals are: i) high currents up to 10 mA or more, ii) extraction efficiency higher than 95%, iii) beam quality at least a factor three better than the prototype.
This cyclotron will allow production of high quantities of Tc99m and other frontier medical isotopes.

Koordinator

ION BEAM APPLICATIONS SA
Netto-EU-Beitrag
€ 166 320,00
Adresse
CHEMIN DU CYCLOTRON 3
1348 Ottignies Louvain La Neuve
Belgien

Auf der Karte ansehen

Region
Région wallonne Prov. Brabant Wallon Arr. Nivelles
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Links
Gesamtkosten
€ 166 320,00