Understanding Lectins' network language with chemical tools: new insights for immunological purposes.

Project description

Insight into dendritic cell function

Dendritic cells (DCs) activate the innate part of the immune system by processing and presenting antigens to T cells. Recognition of carbohydrates takes place through transmembrane C-type lectin receptors (CLRs) on DC surface. To understand how the chemical nature of these antigens influences internalisation, trafficking and presentation, scientists of the EU-funded LectiNet project propose to study the engagement of antigens on CLRs. For this purpose, they will develop heterogenous multivalent polymers as vectors to selectively deliver antigens to DCs and study the downstream events. Results will provide fundamental knowledge on the mechanism of action of the most potent antigen-presenting cells of the immune system.

Fields of science

• medical and health sciences › health sciences › infectious diseases
• natural sciences › chemical sciences › polymer sciences
• medical and health sciences › basic medicine › immunology
• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmaceutical drugs › vaccines
• medical and health sciences › clinical medicine › oncology

Programme(s)

• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2019 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2019
See other projects for this call

Funding Scheme

MSCA-IF-GF - Global Fellowships

Coordinator

NATIONAL UNIVERSITY OF IRELAND GALWAY

Address

University Road
H91 Galway
Ireland

Activity type

Higher or Secondary Education Establishments

Links

EU contribution

€ 275 561,28

Partners (1)

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

United States

Address

Massachusetts Avenue 77
02139 Cambridge

Activity type

Higher or Secondary Education Establishments

Links