Project description
Insight into dendritic cell function
Dendritic cells (DCs) activate the innate part of the immune system by processing and presenting antigens to T cells. Recognition of carbohydrates takes place through transmembrane C-type lectin receptors (CLRs) on DC surface. To understand how the chemical nature of these antigens influences internalisation, trafficking and presentation, scientists of the EU-funded LectiNet project propose to study the engagement of antigens on CLRs. For this purpose, they will develop heterogenous multivalent polymers as vectors to selectively deliver antigens to DCs and study the downstream events. Results will provide fundamental knowledge on the mechanism of action of the most potent antigen-presenting cells of the immune system.
Fields of science
- medical and health scienceshealth sciencesinfectious diseases
- natural scienceschemical sciencespolymer sciences
- medical and health sciencesbasic medicineimmunology
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines
- medical and health sciencesclinical medicineoncology
Programme(s)
Call for proposal
H2020-MSCA-IF-2019
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Funding Scheme
MSCA-IF-GF - Global Fellowships
Coordinator
H91 Galway
Ireland
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Partners (1)
02139 Cambridge
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