Skip to main content

Understanding Lectins' network language with chemical tools: new insights for immunological purposes.

Project description

Insight into dendritic cell function

Dendritic cells (DCs) activate the innate part of the immune system by processing and presenting antigens to T cells. Recognition of carbohydrates takes place through transmembrane C-type lectin receptors (CLRs) on DC surface. To understand how the chemical nature of these antigens influences internalisation, trafficking and presentation, scientists of the EU-funded LectiNet project propose to study the engagement of antigens on CLRs. For this purpose, they will develop heterogenous multivalent polymers as vectors to selectively deliver antigens to DCs and study the downstream events. Results will provide fundamental knowledge on the mechanism of action of the most potent antigen-presenting cells of the immune system.

Call for proposal

H2020-MSCA-IF-2019
See other projects for this call

Coordinator

NATIONAL UNIVERSITY OF IRELAND GALWAY
Address
University Road
H91 Galway
Ireland

See on map

Activity type
Higher or Secondary Education Establishments
EU contribution
€ 275 561,28

Partners (1)

MASSACHUSETTS INSTITUTE OF TECHNOLOGY
United States
Address
Massachusetts Avenue 77
02139 Cambridge

See on map

Activity type
Higher or Secondary Education Establishments