Novel targets to improve allogeneic hematopoietic stem cell transplantation
B cells are pivotal in chronic graft-versus-host disease (cGVHD), which is the most common cause of late non-relapse morbidity and mortality after allogeneic hematopoietic stem cell transplantation. Recent single-cell RNA-sequencing studies demonstrated that AIM2 (absent in melanoma 2) is upregulated in cGVHD patient B cells. Upon DNA binding, the AIM2 protein induces AIM2 inflammasome formation and triggers pro-inflammatory cytokine secretion. Other related studies showed that the enzyme DNase1L3 regulating extracellular DNA exposure could play a pivotal role in B cell development. The EU-funded DABAT project will investigate AIM2 and DNase1L3 in human B cells and in mouse in vivo models. The research will address intrinsic molecular programmes underpinning B cell pathobiology and agents targeting B cells which can be developed for cGVHD treatment.
Fields of science
- natural sciencesbiological sciencesgeneticsDNA
- medical and health sciencesbasic medicineimmunology
- medical and health sciencesmedical biotechnologycells technologiesstem cells
- medical and health sciencesclinical medicinetransplantation
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes
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Funding SchemeMSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
27708 Durham Nc
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