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Deciphering fundamental constraints on pathogen adaptation

Project description

Pathogen infection survival trade-offs

Adaptation to new conditions is a major determinant for evolution, but improvement of one trait often comes at the expense of another. Understanding how this trade-off takes place in pathogens may enhance our ability to predict disease emergence. Using the wheat pathogen Zymoseptoria tritici as a model organism, the EU-funded TRADEOFF project will investigate the environmental and genetic constraints leading to life history trade-offs. Scientists will perform gene expression analysis on global pathogen isolates and determine how trade-offs change in response to environmental conditions. They will also evaluate the importance of genetic constraints in shaping trade-offs. Apart from offering insights into ecology, the project will lay the foundation for exploiting trade-offs to manage disease and improve food security.

Objective

Adaptation is considered to be a fundamental determinant of organismal evolution, but getting better at something may have an evolutionary cost. This limitation is encapsulated in the concept of a trade-off, where improvements in one trait come at the expense of another. For example, pathogens that excel at surviving in their host’s absence are often worse at causing disease, and vice versa. Knowledge of how trade-offs impact pathogens is particularly important as it would enhance our ability to predict disease emergence. However, while observations of trade-offs abound, we know little about why they occur. In order to gain crucial insight into pathogen evolution, I propose to investigate the underlying selective, environmental, and genetic constraints leading to life history trade-offs in Zymoseptoria tritici, an economically important pathogen of wheat in Europe with defined infection and survival stages. We will first determine the selective constraints on adaptation by contrasting the signatures of selection on genes expressed during survival, during infection, or both, across 15 global isolates. Then, by phenotyping a diverse panel of 150 Swiss isolates, we will identify infection-survival trade-offs, and test whether or not the strength and direction of trade-offs change in response to environmental conditions anticipated under future climate change. Finally, we will evaluate the importance of genetic constraints for shaping trade-offs by identifying loci contributing to both infection and survival (i.e. pleiotropy), and will furthermore determine whether or not the mechanisms of pleiotropy are related to carbon metabolism. Identifying the causes of trade-offs in a plant pathogen will not only produce broadly relevant insights into organismal biology and ecology, but will help European scientists exploit trade-offs to sustainably manage disease and bolster food security.

Coordinator

UNIVERSITE DE NEUCHATEL
Net EU contribution
€ 191 149,44
Address
FAUBOURG DE L'HOPITAL 41
2000 NEUCHATEL
Switzerland

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Region
Schweiz/Suisse/Svizzera Espace Mittelland Neuchâtel
Activity type
Higher or Secondary Education Establishments
Links
Total cost
€ 191 149,44