Genetically encoded sensors for imaging neurochemical dynamics in vivo

Project Information

OPTONEUROCHEM

Grant agreement ID: 891959

DOI

10.3030/891959

EC signature date 1 October 2020

Start date 1 February 2021

End date 31 July 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 498 750,00

EU contribution

€ 1 498 750,00

Coordinated by

UNIVERSITAT ZURICH
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Non-peer reviewed articles (5)

Multimodal intrinsic activation of GPCRs in ultrastable plasma membrane nanodomains

Author(s): Gabriele Kockelkoren, Jens Carstensen, Line Lauritsen, Eleftheria Kazepidou, Asger Tonnesen, Christopher G. Shuttle, Paulina S. Kaas, Ankur Gupta, Artù Breuer, Søren G. F. Rasmussen, Loïc Duffet, Tony Warne, Tommaso Patriarchi, Christopher G. Tate, Mark Uline, Dimitrios Stamou
Published in: BioRxiv, 2024, ISSN 2692-8205
Publisher: BioRxiv
DOI: 10.1101/2024.02.28.582451

Locus Coeruleus firing patterns selectively modulate brain activity and dynamics

Author(s): Christina Grimm, Sian N. Duss, Mattia Privitera, Brandon R. Munn, Stefan Frässle, Maria Chernysheva, Tommaso Patriarchi, Daniel Razansky, Nicole Wenderoth, James M. Shine, Johannes Bohacek, Valerio Zerbi
Published in: BioRxiv, 2022, ISSN 2692-8205
Publisher: BioRxiv
DOI: 10.1101/2022.08.29.505672

Prime editing of the β1 adrenoceptor in the brain reprograms mouse behavior

Author(s): Desirée Böck, Lisa Tidecks, Maria Wilhelm, Yanik Weber, Eleonora Ioannidi, Jonas Mumenthaler, Tanja Rothgangl, Lukas Schmidheini, Sharan Janjuha, Tommaso Patriarchi, Gerald Schwank
Published in: BioRxiv, 2022, ISSN 2692-8205
Publisher: BioRxiv
DOI: 10.1101/2023.05.19.541410

Base editing of Ptbp1 in neurons alleviates symptoms in a mouse model for Parkinson’s disease

Author(s): Desirée Böck, Maria Wilhelm, Jonas Mumenthaler, Daniel Fabio Carpanese, Simon d‘Aquin, Alessio Cremonesi, Anahita Rassi, Johannes Häberle, Tommaso Patriarchi, Gerald Schwank
Published in: BioRxiv, 2024, ISSN 2692-8205
Publisher: BioRxiv
DOI: 10.1101/2024.03.22.586274

State of the art imaging of neurotransmission in animal models

Author(s): Tommaso Patriarchi, Anna Beyeler
Published in: Journal of Neuroscience Methods, 2022, ISSN 0165-0270
Publisher: Elsevier BV
DOI: 10.1016/j.jneumeth.2022.109623

Peer reviewed articles (15)

Distinct sub-second dopamine signaling in dorsolateral striatum measured by a genetically-encoded fluorescent sensor

Author(s): Armando G. Salinas, Jeong Oen Lee, Shana M. Augustin, Shiliang Zhang, Tommaso Patriarchi, Lin Tian, Marisela Morales, Yolanda Mateo, David M. Lovinger
Published in: Nature Communications, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-41581-3

Development of a genetically-encoded sensor for probing endogenous nociceptin opioid peptide release

Author(s): Xuehan Zhou, Carrie Stine, Patricia Oliveira Prada, Debora Fusca, Kevin Assoumou, Jan Dernic, Musadiq A. Bhat, Ananya S. Achanta, Joseph C. Johnson, Sanjana Jadhav, Corinna A. Bauder, Lukas Steuernagel, Luca Ravotto, Dietmar Benke, Bruno Weber, Miriam Stoeber, Peter Kloppenburg, Jens C. Brüning, Michael R. Bruchas, Tommaso Patriarchi
Published in: Nature Communications, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-49712-0

A photocaged orexin-B for spatiotemporally precise control of orexin signaling

Author(s): Duffet, Loic; Tatarskiy, Petr V; Harada, Masaya; Williams, Elyse T; Hartrampf, Nina; Patriarchi, Tommaso
Published in: Cell Chemical Biology, 29 (12), Issue 2, 2022, ISSN 2451-9448
Publisher: Elsevier
DOI: 10.3929/ethz-b-000589631

Optical tools for visualizing and controlling human GLP-1 receptor activation with high spatiotemporal resolution

Author(s): Loïc Duffet, Elyse T Williams, Andrea Gresch, Simin Chen, Musadiq A Bhat, Dietmar Benke, Nina Hartrampf, Tommaso Patriarchi
Published in: eLife, 2023, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.86628

A genetically encoded sensor for in vivo imaging of orexin neuropeptides

Author(s): Loïc Duffet, Seher Kosar, Mariangela Panniello, Bianca Viberti, Edward Bracey, Anna D. Zych, Arthur Radoux-Mergault, Xuehan Zhou, Jan Dernic, Luca Ravotto, Yuan-Chen Tsai, Marta Figueiredo, Shiva K. Tyagarajan, Bruno Weber, Miriam Stoeber, Nadine Gogolla, Markus H. Schmidt, Antoine R. Adamantidis, Tommaso Fellin, Denis Burdakov, Tommaso Patriarchi
Published in: Nature Methods, Issue 19, 2022, Page(s) 231-241, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1038/s41592-021-01390-2

Lights, fiber, action! A primer on in vivo fiber photometry

Author(s): Simpson, EH; Akam, T; Patriarchi, T; Blanco-Pozo, M; Burgeno, LM; Mohebi, A; Cragg, SJ; Walton, ME
Published in: Neuron, 112 (5), Issue 3, 2023, ISSN 1097-4199
Publisher: Elsevier
DOI: 10.1016/j.neuron.2023.11.016

A photoswitchable GPCR-based opsin for presynaptic inhibition

Author(s): Bryan A. Copits, Raaj Gowrishankar, Patrick R. O’Neill, Jun-Nan Li, Kasey S. Girven, Judy J. Yoo, Xenia Meshik, Kyle E. Parker, Skylar M. Spangler, Abigail J. Elerding, Bobbie J. Brown, Sofia E. Shirley, Kelly K.L. Ma, Alexis M. Vasquez, M. Christine Stander, Vani Kalyanaraman, Sherri K. Vogt, Vijay K. Samineni, Tommaso Patriarchi, Lin Tian, N. Gautam, Roger K. Sunahara, Robert W. Gereau IV, Mic
Published in: Neuron, 2021, ISSN 1097-4199
Publisher: Elsevier
DOI: 10.1016/j.neuron.2021.04.026

Probing PAC1 receptor activation across species with an engineered sensor

Author(s): Reto B. Cola, Salome N. Niethammer, Preethi Rajamannar, Andrea Gresch, Musadiq A. Bhat, Kevin Assoumou, Elyse T. Williams, Patrick Hauck, Nina Hartrampf, Dietmar Benke, Miriam Stoeber, Gil Levkowitz, Sarah Melzer, Tommaso Patriarchi
Published in: eLife, 2024, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.96496.1

A chemogenetic approach for dopamine imaging with tunable sensitivity.

Author(s): Marie A. Labouesse, Maria Wilhelm, Zacharoula Kagiampaki, Andrew G. Yee, Raphaelle Denis, Masaya Harada, Andrea Gresch, Alina-Măriuca Marinescu, Kanako Otomo, Sebastiano Curreli, Laia Serratosa Capdevila, Xuehan Zhou, Reto B. Cola, Luca Ravotto, Chaim Glück, Stanislav Cherepanov, Bruno Weber, Xin Zhou, Jason Katner, Kjell A. Svensson, Tommaso Fellin, Louis-Eric Trudeau, Christopher P. Ford, Yaro
Published in: Nature Communications, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-49442-3

Stimulation of VTA dopamine inputs to LH upregulates orexin neuronal activity in a DRD2-dependent manner

Author(s): Harada, Masaya; Capdevila, Laia Serratosa; Wilhelm, Maria; Burdakov, Denis; Patriarchi, Tommaso
Published in: eLife, 12, Issue 2, 2023, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.90158.3

Multimodal detection of dopamine by sniffer cells expressing genetically encoded fluorescent sensors

Author(s): Klein Herenbrink, Carmen; Støier, Jonatan Fullerton; Reith, William Dalseg; Dagra, Abeer; Gregorek, Miguel Alejandro Cuadrado; Cola, Reto B; Patriarchi, Tommaso; Li, Yulong; Tian, Lin; Gether, Ulrik; Herborg, Freja
Published in: Communications Biology, Issue 1, 2022, ISSN 2399-3642
Publisher: Nature Portfolio
DOI: 10.1038/s42003-022-03488-5

Engineering, applications, and future perspectives of <scp>GPCR</scp>‐based genetically encoded fluorescent indicators for neuromodulators

Author(s): Valentin Lu Rohner; Paul J. Lamothe‐Molina; Tommaso Patriarchi
Published in: Journal of Neurochemistry, Issue 1, 2024, ISSN 0022-3042
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jnc.16045

Orexin neurons track temporal features of blood glucose in behaving mice

Author(s): Paulius Viskaitis, Alexander L. Tesmer, Ziyu Liu, Mahesh M. Karnani, Myrtha Arnold, Dane Donegan, Eva Bracey, Nikola Grujic, Tommaso Patriarchi, Daria Peleg-Raibstein, Denis Burdakov
Published in: Nature Neuroscience, 2024, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-024-01648-w

A versatile GPCR toolkit to track in vivo neuromodulation: not a one-size-fits-all sensor

Author(s): Marie A. Labouesse, Tommaso Patriarchi
Published in: Neuropsychopharmacology, 2021, ISSN 0893-133X
Publisher: Nature Publishing Group
DOI: 10.1038/s41386-021-00982-y

Sensitive multicolor indicators for monitoring norepinephrine in vivo.

Author(s): Zacharoula Kagiampaki, Valentin Rohner, Cedric Kiss, Sebastiano Curreli, Alexander Dieter, Maria Wilhelm, Masaya Harada, Sian N. Duss, Jan Dernic, Musadiq A. Bhat, Xuehan Zhou, Luca Ravotto, Tim Ziebarth, Laura Moreno Wasielewski, Latife Sönmez, Dietmar Benke, Bruno Weber, Johannes Bohacek, Andreas Reiner, J. Simon Wiegert, Tommaso Fellin & Tommaso Patriarchi
Published in: Nature Methods, 2023, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1038/s41592-023-01959-z