Elucidating how XRN1-mediated RNA degradation controls virus infection

Project description

A new host orchestrator of virus infection

Upon infection, viruses induce host mRNA degradation, a process known to be orchestrated by the exonuclease XRN1. Human cells lacking this protein are refractory to the mosquito-borne sindbis (SINV) virus, clearly underscoring the importance of XRN1 in the infection process. However, the precise mechanism of its action remains elusive. The aim of the EU-funded RNAdeg-Virus project is to investigate the targets of XRN1 using cutting-edge system-wide approaches and delineate the molecular events that trigger XRN1 activation. The project's results will lead to the identification of potential targets for antiviral drugs, with obvious medical and socio-economic consequences.

Fields of science

• natural sciences › biological sciences › microbiology › virology
• medical and health sciences › clinical medicine › oncology
• natural sciences › biological sciences › genetics › RNA
• natural sciences › biological sciences › biochemistry › biomolecules › proteins › enzymes
• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmaceutical drugs › antivirals

Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2019 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2019

See other projects for this call

Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

Net EU contribution

€ 212 933,76

Address

Wellington Square University Offices
OX1 2JD Oxford
United Kingdom

Region

South East (England) › Berkshire, Buckinghamshire and Oxfordshire › Oxfordshire

Activity type

Higher or Secondary Education Establishments

Links

Other funding

€ 0,00