Exploring the role of serotonin in synaptic plasticity in the prefrontal cortex
Serotonin or 5-hydroxytryptamine (5-HT) is an important neurotransmitter in the brain and periphery. The prefrontal cortex is essential for top-down control of higher-order executive processes such as learning, working memory and cognitive flexibility and it expresses five types of 5-HT receptor subtypes. Evidence supports a link between dysfunctional serotonergic modulation and working memory deficits, yet the cellular mechanisms are not known. The EU-funded PIANISM project is investigating the role of 5-HT in working memory formation. The team is manipulating cells in brain slices and measuring effects on characteristic synaptic activity thought to underly memory formation in the prefrontal cortex. Insight could be important for therapeutic targets to treat working memory deficits common in some neurodegenerative diseases and schizophrenia.
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Funding SchemeMSCA-IF-EF-ST - Standard EF