Descrizione del progetto
Un nuovo modello per comprendere le proteine
Le proteine sono grandi macchine molecolari che svolgono diversi ruoli critici nelle cellule e, di conseguenza, nella struttura, funzione e regolazione del corpo. Il progetto EMPHABIOSYS, finanziato dall’UE, migliorerà la nostra comprensione delle proteine sulla base di un modello che collega le fasi polimeriche convenzionali e quelle adottate dalle biomolecole. Esso applicherà un metodo altamente interdisciplinare che include biologia, chimica, informatica, fisica e matematica. In particolare, il progetto cerca di identificare la selezione della struttura dello stato nativo e la propensione delle proteine a formare amiloidi connessi a malattie debilitanti, nonché a indagare le dinamiche di ripiegamento proteico ed errato ripiegamento. Studierà anche le interazioni tra DNA e proteine.
Obiettivo
The aim of the project is to understand proteins, the molecular machines of life, using a highly interdisciplinary approach encompassing biology, chemistry, computer science, physics, and mathematics. Our work will be directly relevant to tackle the societally important problem of human health, it will be useful for making nifty machines in the lab and eventually could form the basis for the creation of artificial life itself. The starting ingredient of the EMPHABIOSYS project is a model for proteins recently developed by the applicant and her supervisors that serves to bridge conventional polymer phases and those adopted by biomolecules. We will proceed with a hierarchical inclusion of increasing levels of details that is fully controlled and will provide invaluable insights on the underlying mechanisms and direct comparison to experiments. We will incorporate directional interactions mimicking hydrogen bonds; we will include sequence specificity to understand the selection of the native state structure and the propensity of proteins to form amyloid implicated in debilitating diseases; we will then proceed to an understanding of the dynamics of protein folding and misfolding; and ultimately to the study of protein-DNA interactions. The first two steps will be carried out at University of Oregon under the guidance of international leaders and will enable me to master experimental approaches along with mathematical rigor and physical intuition. The final step will be carried out during the third year of the project at Ca’ Foscari University of Venice and will benefit from the network of collaborations established with the Universities of Vienna, San Sebastian and Oslo. The award of the fellowship will be crucial for me to establish my scientific career, to communicate the joy of doing science, to inspire and mentor the next generation of young women (and men) to become scientific leaders, and to make our world a better place in the spirit of Marie Curie.
Campo scientifico
Parole chiave
Programma(i)
Argomento(i)
Meccanismo di finanziamento
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)Coordinatore
30123 Venezia
Italia