Egr1 and Egr2 regulate opposite transcriptional programs in macrophages

Project description

Finding the 'switches' to fine-tune macrophage phenotypes in inflammatory diseases

The immune system has many soldiers to fight its battles against invaders. Among them are macrophages, a type of white blood cell that responds to an infection or to an accumulation of damaged or dead cells. As their name suggests, they are large cells that 'eat' their targets and can start an immune response when it 'sees' an infection. Inflammation is vital to the immune system's response to injury and infection, however, these properties can turn against the body in diseases such as atherosclerosis and sepsis. The EU-funded MacrophageEGR project is investigating two different transcriptional regulators whose activation by pro- or anti-inflammatory signals either enhances or represses macrophage activation. By targeting these transcriptional regulators, it may be possible to prevent macrophages from developing phenotypes favouring inflammatory diseases.

Fields of science

• medical and health sciences › health sciences › public and environmental health › epidemics prevention › immunisation
• natural sciences › biological sciences › genetics and heredity › dna
• medical and health sciences › health sciences › inflammatory diseases
• medical and health sciences › clinical medicine › cardiology › cardiovascular diseases › arteriosclerosis

Programme(s)

• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2019 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2019
See other projects for this call

Funding Scheme

MSCA-IF-EF-RI - RI – Reintegration panel

Coordinator

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM

Address

Meibergdreef 15
1105AZ Amsterdam
Netherlands

Activity type

Higher or Secondary Education Establishments

EU contribution

€ 175 572,48