Descripción del proyecto
Información sobre la consolidación de la memoria
La transformación de los sucesos en memoria a largo plazo, proceso que se conoce como consolidación de la memoria, implica a varias regiones del encéfalo. Datos recientes indican que la interacción entre el núcleo lateral dorsal del tálamo y la corteza cingulada anterior (CCA) es fundamental para la consolidación de la memoria. Los científicos del proyecto financiado con fondos europeos METHA pretenden investigar el circuito entre el núcleo lateral dorsal del tálamo y la corteza cingulada anterior y, en concreto, cómo las neuronas de estas regiones procesan la información adquirida durante la formación para consolidarla y recordarla en un momento posterior. Los resultados brindarán una mejor comprensión de la memoria y de patologías relacionadas como el trastorno por estrés postraumático y la demencia.
Objetivo
Memory consolidation is the process by which memories are converted into a long-lasting form allowing its recall later in time. It has been shown that memory consolidation is supported by the coordinated activation of a network of brain regions. In this regard, the hippocampus-cortical communication has been largely studied. Recent evidences point to the thalamus as a key region mediating this dialogue. In particular, the Laterodorsal Nucleus of the Thalamus (LD) activity has been shown to be essential for remote memory recall. Moreover, the LD shows high anatomical and functional connectivity with the Anterior Cingulate Cortex (ACC) which is a key structure for consolidation and remote memory recall. These data suggest that this LD-ACC pathway may be crucial during memory consolidation. The LD is known to harbor Head Direction (HD) cells which are neurons that fire to specific orientations of the animal head. Therefore, we hypothesized that the activity of the LD-ACC circuit represents spatial information that is required for recall of contextual fear memory. The present project was designed to test this hypothesis using a multi-level approach, that is unique in the field. First, we will address the causal role of the LD-ACC pathway in the recall of fear memory, by modulating its activity using optogenetics. Then we will investigate how LD cells, and LD-ACC projecting cells, are processing acquired information during the training to consolidate and recall them at a remote time point by directly visualizing the activity of the LD during acquisition and recall of contextual conditioned fear. The expected results will have a significant impact in the memory and in the spatial navigation field, and are of key importance to better understand memory and related pathologies such as post-traumatic stress disorder and dementia.
Ámbito científico
Programa(s)
Régimen de financiación
MSCA-IF-EF-ST - Standard EFCoordinador
75231 Paris
Francia