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CORDIS - Forschungsergebnisse der EU
CORDIS

Functional interaction between a prefrontal and a thalamic nucleus for the consolidation of spatial memories

Projektbeschreibung

Einblicke in die Gedächtniskonsolidierung

Ereignisse in bleibende Erinnerungen umzuwandeln, ist ein Prozess, der als Gedächtniskonsolidierung bekannt ist. Er findet in vielen Regionen des Gehirns statt. Neuere Erkenntnisse deuten nun darauf hin, dass für die Gedächtniskonsolidierung das Zusammenspiel zwischen dem laterodorsalen Kern des Thalamus und dem anterioren cingulären Kortex von übergeordneter Bedeutung ist. Die Forschungsgruppe des EU-finanzierten Projekts METHA plant die Untersuchung der Verschaltung zwischen laterodorsalem Kern des Thalamus und anteriorem cingulären Kortex, dabei insbesondere, wie die Neuronen in diesen Regionen während des Trainings erworbene Informationen verarbeiten, um sie zu festigen und zu einem späteren Zeitpunkt wieder abrufen zu können. Die Ergebnisse werden ein besseres Verständnis des Gedächtnisses und damit assoziierter Pathologien wie etwa posttraumatischer Belastungsstörungen und Demenz ermöglichen.

Ziel

Memory consolidation is the process by which memories are converted into a long-lasting form allowing its recall later in time. It has been shown that memory consolidation is supported by the coordinated activation of a network of brain regions. In this regard, the hippocampus-cortical communication has been largely studied. Recent evidences point to the thalamus as a key region mediating this dialogue. In particular, the Laterodorsal Nucleus of the Thalamus (LD) activity has been shown to be essential for remote memory recall. Moreover, the LD shows high anatomical and functional connectivity with the Anterior Cingulate Cortex (ACC) which is a key structure for consolidation and remote memory recall. These data suggest that this LD-ACC pathway may be crucial during memory consolidation. The LD is known to harbor Head Direction (HD) cells which are neurons that fire to specific orientations of the animal head. Therefore, we hypothesized that the activity of the LD-ACC circuit represents spatial information that is required for recall of contextual fear memory. The present project was designed to test this hypothesis using a multi-level approach, that is unique in the field. First, we will address the causal role of the LD-ACC pathway in the recall of fear memory, by modulating its activity using optogenetics. Then we will investigate how LD cells, and LD-ACC projecting cells, are processing acquired information during the training to consolidate and recall them at a remote time point by directly visualizing the activity of the LD during acquisition and recall of contextual conditioned fear. The expected results will have a significant impact in the memory and in the spatial navigation field, and are of key importance to better understand memory and related pathologies such as post-traumatic stress disorder and dementia.

Koordinator

ECOLE SUPERIEURE DE PHYSIQUE ET DECHIMIE INDUSTRIELLES DE LA VILLE DEPARIS
Netto-EU-Beitrag
€ 196 707,84
Adresse
RUE VAUQUELIN 10
75231 Paris
Frankreich

Auf der Karte ansehen

Region
Ile-de-France Ile-de-France Paris
Aktivitätstyp
Higher or Secondary Education Establishments
Links
Gesamtkosten
€ 196 707,84