Descrizione del progetto
Riabilitazione neuromotoria adattativa per pazienti affetti da sclerosi multipla
L’obiettivo del progetto REMAp, finanziato dall’UE, è quello di creare un nuovo approccio alla riabilitazione neuromotoria nei pazienti affetti da sclerosi multipla (SM), avvalendosi di meccanismi riabilitativi basati su interfacce uomo-macchina. L’idea è che durante il percorso di riabilitazione, l’intero sistema nervoso, dalle parti periferiche al cervello, attraversa una riorganizzazione che può essere sfruttata per progettare interventi più efficaci. Saranno impiegate sinergie muscolari e cinematiche per sviluppare uno strumento di valutazione funzionale specifico per la SM, al fine di monitorare la malattia e gli effetti del trattamento. I dati saranno applicati alla progettazione di un’interfaccia uomo-macchina e di esercizi specifici, per aiutare i pazienti con SM a raggiungere il pieno potenziale a livello funzionale. La natura adattativa dell’interfaccia uomo-macchina andrà a beneficio di pazienti con livelli diversi di compromissione.
Obiettivo
The project AIMS AT developing and validating a novel approach to neuromotor rehabilitation of persons with Multiple Sclerosis (PwMS), rooted in the physiological mechanisms of recovery and based on Body-Machine Interfaces (BoMI). This project is INNOVATIVE in that it explicitly takes subjects’ impairments into account, first characterizing it and then inherently adapting and individualizing the rehabilitative interventions.
The project is based on the IDEA that after a neurologic disease or during a rehabilitative training all the nervous system (from the periphery to the brain) go through a reorganization and knowing these changes can be exploited to design more effective and tailored intervention. Muscle synergies in combination with kinematic synergies will be used to develop a MS- specific tool for a complete functional evaluation, to monitor progress of the disease and effects of treatments, and they will be use to design a BoMI that will exploit the residual mobility with patient-specific exercises helping PwMS to reach their full functional potential. Because of their adaptive nature, BoMIs will benefit PwMS with different degrees of impairment adapting to their changing conditions (worsening due to the disease progress or improving due to therapy). The project will evaluate BoMI training-induced reorganization in the brain and spinal cord with innovative imaging techniques. This will allow building solid foundations for a comprehensive understanding of use-dependent plasticity of the sensorimotor cortex and sensorimotor tracts in healthy subject and in PwMS. The expected outcome will be a novel method and a class of highly adaptive, personalized devices that not only maximize the restoration of functional performance, but also promote the functional reorganization of body abilities.
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Meccanismo di finanziamento
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)Coordinatore
16126 Genova
Italia