Skip to main content
Weiter zur Homepage der Europäischen Kommission (öffnet in neuem Fenster)
Deutsch de
CORDIS - Forschungsergebnisse der EU
CORDIS

Enzyme-conjugated DNA nanoswitches for biosensing applications

Projektbeschreibung

Enzymbasierte Nano-Biosensoren für diagnostische Zwecke

Das EU-finanzierte Projekt ENZYME-SWITCHES ist ein interdisziplinäres Vorhaben, das zum Ziel hat, neuartige enzymbasierte Biosensoren für diagnostische Anwendungen zu entwickeln. Forschende werden die hohe Spezifität und Empfindlichkeit von Enzymen mit der programmierbaren Flexibilität und Vielseitigkeit synthetischer responsiver DNA-Nanogeräte kombinieren, um DNA-konjugierte Enzyme als sensitive diagnostische Marker zu erzeugen. An dem Projekt sind Fachkräfte aus der Molekularbiologie, der Enzymologie, der Biosensortechnologie, dem Bereich der Biotechnikgeräte und der Biophysik sowie der DNA-Nanotechnologie, der analytischen Chemie und der Elektrochemie beteiligt.

Ziel

WHY: Diagnostic markers detection plays a crucial role in the diagnosis of human disorders. Unfortunately, however, current methods routinely used for the detection of these biomarkers still require sophisticated equipment, washing intensive, reagent-intensive multi-step processes. In attempt to overcome the cited limitations, the development of platforms supporting the sensitive, specific, rapid and easy to use measurement for several diagnostic biomarkers, directly in real samples, is urgently needed.

WHAT: ENZYME-SWITCHES is a multidisciplinary and interdisciplinary programme with the principal aim to develop a new generation of enzyme-based biosensors that could prove transformative for diagnostic applications. To achieve this goal, I will join the high specificity and sensitivity of enzymes, and the high programmability and versatility of synthetic responsive DNA nanodevices to develop DNA-conjugated enzymes able to provide sensitive detection of a wide range of diagnostic markers.

HOW: This challenging objective will be reached thanks to the multidisciplinary and complementary approach of the outgoing and incoming research groups. I will join the expertise of Prof. Plaxco (outgoing supervisor) in molecular biology, enzymes, biosensor technology, bioengineering device and biophysic with that of Prof. Ricci (incoming supervisor) in the DNA-Nanotechnology field, analytical chemistry and electrochemistry to optimize the proposed new biosensors platform.

I have already a promising research profile demonstrated by a strong publication track-record, by several awards received and by fruitful international mobility. Thanks to this MSC Fellowship, I will further strengthen my CV and diversify my scientific knowledge acquiring cutting-edge competences as well as complementary skills, which will boost my scientific independence and my future career.

Wissenschaftliches Gebiet (EuroSciVoc)

Schlüsselbegriffe

Programm/Programme

Thema/Themen

Finanzierungsplan

MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)

Alle im Rahmen dieses Finanzierungsinstruments finanzierten Projekte anzeigen

Aufforderung zur Vorschlagseinreichung

(öffnet in neuem Fenster) H2020-MSCA-IF-2019

Alle im Rahmen dieser Aufforderung zur Einreichung von Vorschlägen finanzierten Projekte anzeigen

Koordinator

UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA
Netto-EU-Beitrag
€ 168 369,60
Adresse
VIA CRACOVIA 50
00133 Roma
Italien
Region
Centro (IT) Lazio Roma
Aktivitätstyp
Higher or Secondary Education Establishments
Links
Gesamtkosten
€ 168 369,60

Partner (1)