Skip to main content

Understanding the role of lysosomes in the intercellular TNT-mediated spreading of α-synuclein and the impact of lysosomal dysfunction

Project description

The role of lysosomes in the intercellular spreading of α-synuclein

The accumulation of misfolded protein aggregates in affected brain regions is a hallmark shared by several neurodegenerative diseases (ND). Misfolded alpha-synuclein (α-syn) accumulates in Parkinson’s disease, and the mechanisms linked to the spreading of α-syn have been implicated in its pathology progression. Recent studies have demonstrated that α-syn fibrils spread between neuronal cells through tunnelling nanotubes (TNTs), thin actin-based membrane protrusions mediating the intercellular transport of various cargoes. These α-syn fibrils induce the aggregation of soluble α-syn in receiving cells. The EU-funded LySyT project will uncover the mechanism by which α-syn fibrils escape from lysosomes to induce the aggregation of monomers in acceptor cells, aiming to understand the correlation between lysosomal storage diseases and NDs.

Call for proposal

See other projects for this call


Rue Du Docteur Roux 25-28
75724 Paris Cedex 15
Activity type
Research Organisations
EU contribution
€ 184 707,84