Screening of inFlammation to enable personalized Medicine

Información del proyecto

SciFiMed

Identificador del acuerdo de subvención: 899163

DOI

10.3030/899163

Proyecto cerrado

Fecha de la firma de la CE 26 Mayo 2020

Fecha de inicio 1 Enero 2021

Fecha de finalización 30 Junio 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Coste total

€ 3 691 801,25

Aportación de la UE

€ 3 559 801,25

Coordinado por

PHILIPPS UNIVERSITAET MARBURG
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (3)

LFA feasibility

Report on first 7pley LFA feasibilty study

Press release 1

Kick of Press release

Description dynamic range LFAs

Report dynamic ranges for all singleanalyte LFA

Websites, patent fillings, videos etc. (3)

Webpage, Logo and updates

Webpage proposed domain scifimedeu SciFiMed logo and continuous updates

SciFiMed Flyer
SciFiMed Video

SciFiMed introduction video

Publicaciones

Non-peer reviewed articles (2)

Factor H-related protein 3 (FHR-3) deposition in kidney allografts – localization and correlation with complement activation

Autores: Felix Poppelaars, Nicole Schäfer, Anita H. Meter-Arkema, Shrey Purohit, Bernardo Faria, Mariana Gaya da Costa, V. Michael Holers, Mohamed R. Daha, Diana Pauly, Marc A. Seelen, Joshua M. Thurman
Publicado en: medRxiv, 2023, ISSN 3067-2007
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.10.24.23297478

Editorial: Current challenges in complement diagnostics

Autores: Per H. Nilsson, Lillemor Skattum, Erik J. M. Toonen
Publicado en: Frontiers in Immunology, Edición 14, 2023, ISSN 1664-3224
Editor: Frontiers Research Foundation
DOI: 10.3389/fimmu.2023.1334050

Peer reviewed articles (26)

A Family Affair: Addressing the Challenges of Factor H and the Related Proteins

Autores: Felix Poppelaars, Elena Goicoechea de Jorge, Ilse Jongerius, Antje J. Baeumner, Mark-Steven Steiner, Mihály Józsi, Erik J. M. Toonen, Diana Pauly
Publicado en: Frontiers in Immunology, Edición 12, 2021, ISSN 1664-3224
Editor: Lausanne: Frontiers Media S.A., 2010-
DOI: 10.3389/fimmu.2021.660194

Complement alternative pathway determines disease susceptibility and severity in antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis

Autores: Laura Lucientes-Continente, Gema Fernández-Juárez, Bárbara Márquez-Tirado, Laura Jiménez-Villegas, Mercedes Acevedo, Teresa Cavero, Luís Sánchez Cámara, Juliana Draibe, Paula Anton-Pampols, Fernando Caravaca-Fontán, Manuel Praga, Javier Villacorta, Elena Goicoechea de Jorge
Publicado en: Kidney International, Edición 105, 2024, Página(s) 177-188, ISSN 0085-2538
Editor: Blackwell Publishing Inc.
DOI: 10.1016/j.kint.2023.10.013

The human factor H protein family – an update

Autores: Sándor, Noémi, Schneider, Andrea E., Matola, Alexandra T., Barbai, Veronika H., Bencze, Dániel, Hammad, Hani Hashim, Papp, Alexandra, Kövesdi, Dorottya, Uzonyi, Barbara, Józsi, Mihály
Publicado en: Frontiers In Immunology, Edición Volume 15 - 2024, 2024, ISSN 1664-3224
Editor: Frontiers Media SA
DOI: 10.3389/fimmu.2024.1135490

Complement Factor H-Related Proteins FHR1 and FHR5 Interact With Extracellular Matrix Ligands, Reduce Factor H Regulatory Activity and Enhance Complement Activation.

Autores: Alexandra Papp; Krisztián Papp; Barbara Uzonyi; Marcell Cserhalmi; Ádám I. Csincsi; Zsóka Szabó; Zsófia Bánlaki; David Ermert; Zoltán Prohászka; Anna Erdei; Viviana P. Ferreira; Anna M. Blom; Mihály Józsi
Publicado en: Frontiers in Immunology, Edición 13, 2022, ISSN 1664-3224
Editor: Frontiers Media S.A.
DOI: 10.3389/fimmu.2022.845953

Editorial: Updates on the complement system in kidney diseases

Autores: Bulla R., Józsi M
Publicado en: Frontiers in Immunology, Edición 14, 2023, ISSN 1664-3224
Editor: Frontiers Media S.A.
DOI: 10.3389/fimmu.2023.1196487

Factor H-related 2 levels dictate FHR dimer composition

Autores: Bert R. J. Veuskens, Mieke C. Brouwer, Gerard van Mierlo, Judy Geissler, Karin van Leeuwen, Maaike Derlagen, Nadia C. H. Keijzer, Mark Hoogenboezem, Taco W. Kuijpers, Richard B. Pouw
Publicado en: Scientific Reports, Edición 15, 2025, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-025-94064-4

Autoantibodies Against Factor B and Factor H Without Pathogenic Effects in a Patient with Immune Complex-Mediated Membranoproliferative Glomerulonephritis

Autores: Alexandra T. Matola, Dorottya Csuka, Ágnes Szilágyi, Michael Rudnicki, Zoltán Prohászka, Mihály Józsi, Barbara Uzonyi
Publicado en: Biomedicines, Edición 13, 2025, Página(s) 648, ISSN 2227-9059
Editor: MDPI AG
DOI: 10.3390/biomedicines13030648

Multiplexed electrochemical liposomes applied to the detection of nucleic acids for Influenza A, Influenza B and SARS-CoV-2

Autores: Florian Gerstl, Michael Loessl, Veronika Borggraefe, Antje J. Baeumner
Publicado en: Analytical and Bioanalytical Chemistry, Edición 416, 2024, Página(s) 3487-3500, ISSN 1618-2642
Editor: Springer Verlag
DOI: 10.1007/s00216-024-05145-8

Decreased complement 4 and interleukin-10 as biomarkers in aqueous humour for non-exudative age-related macular degeneration: a case control study

Autores: Juliane Schikora, Aaron Dort, Hannah N. Wolf, Mihály Józsi, Richard B. Pouw, Thomas Bertelmann, Dirk Bahlmann, Christian van Oterendorp, Nicolas Feltgen, Hans Hoerauf, Diana Pauly, Jannis Klemming
Publicado en: Journal of Translational Medicine, Edición 23, 2025, ISSN 1479-5876
Editor: BioMed Central
DOI: 10.1186/s12967-024-05909-x

The Factor H protein family: The switchers of the complement alternative pathway

Autores: Laura Lucientes‐Continente; Bárbara Márquez‐Tirado; Elena Goicoechea de Jorge
Publicado en: Immunological Reviews, Edición 313(1), 2023, Página(s) 25-45, ISSN 0105-2896
Editor: Blackwell Publishing Inc.
DOI: 10.1111/imr.13166

Development and characterization of novel ELISAs for the specific quantification of the factor H-related proteins 2, 3, 4 and 5

Autores: Mara van Rossum, Bert R.J. Veuskens, Mieke C. Brouwer, Gerard van Mierlo, Laura Lucientes-Continente, Elena Goicoechea de Jorge, Barbara Uzonyi, Alexandra T. Matola, Mihály Józsi, Günter Müller, Anita M. Meter-Arkema, Felix Poppelaars, Diana Pauly, Richard B. Pouw, Erik J.M. Toonen
Publicado en: Journal of Innate Immunity, 2025, Página(s) 1-24, ISSN 1662-811X
Editor: Karger AG
DOI: 10.1159/000545139

The Contribution of Complement to the Pathogenesis of IgA Nephropathy: Are Complement-Targeted Therapies Moving from Rare Disorders to More Common Diseases?

Autores: Felix Poppelaars; Bernardo Faria; Wilhelm Schwaeble; Mohamed R. Daha
Publicado en: Journal of Clinical Medicine, Edición Vol 10, Iss 4715, p 4715 (2021), 2021, ISSN 2077-0383
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.17863/cam.77005

Editorial: Function and Dysfunction of Complement Factor H

Autores: Mihály Józsi, Pauli Nigel Barlow and Seppo Meri
Publicado en: Frontiers in Immunology, Edición 12, 2022, ISSN 1664-3224
Editor: Frontiers S.A.
DOI: 10.3389/fimmu.2021.831044

Factor H-Related Protein 1 Drives Disease Susceptibility and Prognosis in C3 Glomerulopathy.

Autores: Bárbara Márquez-Tirado; Josué Gutiérrez-Tenorio; Agustín Tortajada; Laura Lucientes Continente; Fernando Caravaca-Fontán; Talat H. Malik; Raquel Roldán Montero; Sandra Elías; Ana Saiz Gonzalez; Gema Fernández-Juarez; Pilar Sánchez-Corral; Matthew C. Pickering; Manuel Praga; Santiago Rodríguez de Córdoba; Elena Goicoechea de Jorge
Publicado en: Journal of the American Society of Nephrology, Edición Jun;33(6), 2022, Página(s) 1137-1153, ISSN 1046-6673
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1681/asn.2021101318

Evaluating the clinical utility of measuring levels of factor H and the related proteins

Autores: Pratiti Banerjee; Bert R.J. Veuskens; Elena Goicoechea de Jorge; Mihály Józsi; Antje J. Baeumner; Mark-Steven Steiner; Richard B. Pouw; Erik J.M. Toonen; Diana Pauly; Felix Poppelaars
Publicado en: Molecular Immunology, Edición 151, 2022, ISSN 0161-5890
Editor: Pergamon Press
DOI: 10.1016/j.molimm.2022.08.010

The Factor H protein family: The switchers of the complement alternative pathway

Autores: Laura Lucientes‐Continente, Bárbara Márquez‐Tirado, Elena Goicoechea de Jorge
Publicado en: Immunological Reviews, Edición 313, 2023, Página(s) 25-45, ISSN 0105-2896
Editor: Blackwell Publishing Inc.
DOI: 10.1111/imr.13166

Prognostic significance of serum complement activation, neutrophil extracellular traps and extracellular DNA in newly diagnosed epithelial ovarian cancer

Autores: Jason Ricciuti, Qian Liu, A.N.M. Nazmul H. Khan, Janine M. Joseph, Bert Veuskens, Thejaswini Giridharan, Sora Suzuki, Tiffany Emmons, Michael Yaffe, Taco W. Kuijpers, Ilse Jongerius, Mieke Brouwer, Richard B. Pouw, Kunle Odunsi, Peter Frederick, Katherine LaVigne Mager, Shashikant Lele, Nicole Gaulin, Christiane Hakim, Robert P. Edwards, Alexander B. Olawaiye, Paniti Sukamanovich, Sarah Taylor, Es
Publicado en: Gynecologic Oncology, Edición 193, 2025, Página(s) 49-57, ISSN 0090-8258
Editor: Academic Press
DOI: 10.1016/j.ygyno.2024.12.006

Common haplotypes within the chromosome 1q31.3 region determine systemic concentrations of the entire complement factor H protein family

Autores: Bert R.J. Veuskens, Mara Van Rossum, Emi Cattenstart, Mieke C. Brouwer, Gerard van Mierlo, Judy Geissler, Karin van Leeuwen, Jin Liu, Robert A. Anstadt, Burt T. Richards, Gregory S. Hageman, Taco W. Kuijpers, Erik J.M. Toonen, Richard B. Pouw
Publicado en: Journal of Innate Immunity, 2025, Página(s) 1-26, ISSN 1662-811X
Editor: Karger AG
DOI: 10.1159/000545342

Factor H–related proteins and their associated disorders

Autores: Mihály Józsi, Barbara Uzonyi
Publicado en: Journal of Allergy and Clinical Immunology, 2025, ISSN 0091-6749
Editor: Mosby Inc.
DOI: 10.1016/j.jaci.2025.05.024

Encapsulants Affect Liposome Surface Interactions with Biological Systems

Autores: Clemens Spitzenberg, Christoph Bruckschlegel, Ferdinand Holzhausen, Sebastian Boesl‐Bichlmeier, Coralie Pasquier, Patrick Nuernberger, Pierre Bauduin, Antje J. Baeumner
Publicado en: Small, 2025, ISSN 1613-6810
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202505312

Complement Factor H Family Proteins Modulate Monocyte and Neutrophil Granulocyte Functions

Autores: Éva Kárpáti, Mariann Kremlitzka, Noémi Sándor, Dávid Hajnal, Andrea E. Schneider and Mihály Józsi
Publicado en: Frontiers in Immunology, Edición 12:660852, 2021, ISSN 1664-3224
Editor: Frontiers Media S.A.
DOI: 10.3389/fimmu.2021.660852

Pitfalls in complement analysis: A systematic literature review of assessing complement activation

Autores: Ricardo J. M. G. E. Brandwijk, Marloes A. H. M. Michels, Mara van Rossum, Aline H. de Nooijer, Per H. Nilsson, Wieke C. C. de Bruin and Erik J. M. Toonen
Publicado en: Frontiers in Immunology, Edición 13, 2022, ISSN 1664-3224
Editor: Frontiers S.A.
DOI: 10.3389/fimmu.2022.1007102

Complement Factor H-Related Proteins FHR1 and FHR5 Interact With Extracellular Matrix Ligands, Reduce Factor H Regulatory Activity and Enhance Complement Activation

Autores: Alexandra Papp, Krisztián Papp, Barbara Uzonyi, Marcell Cserhalmi, Ádám I. Csincsi, Zsóka Szabó, Zsófia Bánlaki, David Ermert, Zoltán Prohászka, Anna Erdei, Viviana P. Ferreira, Anna M. Blom, Mihály Józsi
Publicado en: Frontiers in Immunology, Edición 13, 2023, Página(s) 845953, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2022.845953

Factor H–Related Protein 1 Drives Disease Susceptibility and Prognosis in C3 Glomerulopathy

Autores: Bárbara Márquez-Tirado, Josué Gutiérrez-Tenorio, Agustín Tortajada, Laura Lucientes Continente, Fernando Caravaca-Fontán, Talat H. Malik, Raquel Roldán Montero, Sandra Elías, Ana Saiz Gonzalez, Gema Fernández-Juarez, Pilar Sánchez-Corral, Matthew C. Pickering, Manuel Praga, Santiago Rodríguez de Córdoba, Elena Goicoechea de Jorge
Publicado en: Journal of the American Society of Nephrology, Edición 33, 2024, Página(s) 1137-1153, ISSN 1046-6673
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1681/asn.2021101318

Complement Factor H-Related 3 Enhanced Inflammation and Complement Activation in Human RPE Cells

Autores: Nicole Schäfer, Anas Rasras, Delia M. Ormenisan, Sabine Amslinger, Volker Enzmann, Herbert Jägle and Diana Pauly
Publicado en: Frontiers in Immunology, Edición 12:769242, 2021, ISSN 1664-3224
Editor: Frontiers Media S.A
DOI: 10.3389/fimmu.2021.769242

Functional and structural characterization of mouse Factor H-related B protein unveils a novel dimerization domain shared by FHR-B and FH

Autores: Adrián Martín-Ambrosio Doménech, Silvia González Sanz, Bárbara Márquez Tirado, Lucia Juana-López, Elena Goicoechea de Jorge, Santiago Rodríguez de Córdoba, Héctor Martín Merinero
Publicado en: Frontiers in Immunology, Edición 16, 2025, ISSN 1664-3224
Editor: Frontiers Research Foundation
DOI: 10.3389/fimmu.2025.1522651