Screening of inFlammation to enable personalized Medicine

Informazioni relative al progetto

SciFiMed

ID dell’accordo di sovvenzione: 899163

DOI

10.3030/899163

Progetto chiuso

Data della firma CE 26 Maggio 2020

Data di avvio 1 Gennaio 2021

Data di completamento 30 Giugno 2025

Finanziato da

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Costo totale

€ 3 691 801,25

Contributo UE

€ 3 559 801,25

Coordinato da

PHILIPPS UNIVERSITAET MARBURG
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (3)

LFA feasibility

Report on first 7pley LFA feasibilty study

Press release 1

Kick of Press release

Description dynamic range LFAs

Report dynamic ranges for all singleanalyte LFA

Websites, patent fillings, videos etc. (3)

Webpage, Logo and updates

Webpage proposed domain scifimedeu SciFiMed logo and continuous updates

SciFiMed Flyer
SciFiMed Video

SciFiMed introduction video

Pubblicazioni

Non-peer reviewed articles (2)

Factor H-related protein 3 (FHR-3) deposition in kidney allografts – localization and correlation with complement activation

Autori: Felix Poppelaars, Nicole Schäfer, Anita H. Meter-Arkema, Shrey Purohit, Bernardo Faria, Mariana Gaya da Costa, V. Michael Holers, Mohamed R. Daha, Diana Pauly, Marc A. Seelen, Joshua M. Thurman
Pubblicato in: medRxiv, 2023, ISSN 3067-2007
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.10.24.23297478

Editorial: Current challenges in complement diagnostics

Autori: Per H. Nilsson, Lillemor Skattum, Erik J. M. Toonen
Pubblicato in: Frontiers in Immunology, Numero 14, 2023, ISSN 1664-3224
Editore: Frontiers Research Foundation
DOI: 10.3389/fimmu.2023.1334050

Peer reviewed articles (26)

A Family Affair: Addressing the Challenges of Factor H and the Related Proteins

Autori: Felix Poppelaars, Elena Goicoechea de Jorge, Ilse Jongerius, Antje J. Baeumner, Mark-Steven Steiner, Mihály Józsi, Erik J. M. Toonen, Diana Pauly
Pubblicato in: Frontiers in Immunology, Numero 12, 2021, ISSN 1664-3224
Editore: Lausanne: Frontiers Media S.A., 2010-
DOI: 10.3389/fimmu.2021.660194

Complement alternative pathway determines disease susceptibility and severity in antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis

Autori: Laura Lucientes-Continente, Gema Fernández-Juárez, Bárbara Márquez-Tirado, Laura Jiménez-Villegas, Mercedes Acevedo, Teresa Cavero, Luís Sánchez Cámara, Juliana Draibe, Paula Anton-Pampols, Fernando Caravaca-Fontán, Manuel Praga, Javier Villacorta, Elena Goicoechea de Jorge
Pubblicato in: Kidney International, Numero 105, 2024, Pagina/e 177-188, ISSN 0085-2538
Editore: Blackwell Publishing Inc.
DOI: 10.1016/j.kint.2023.10.013

The human factor H protein family – an update

Autori: Sándor, Noémi, Schneider, Andrea E., Matola, Alexandra T., Barbai, Veronika H., Bencze, Dániel, Hammad, Hani Hashim, Papp, Alexandra, Kövesdi, Dorottya, Uzonyi, Barbara, Józsi, Mihály
Pubblicato in: Frontiers In Immunology, Numero Volume 15 - 2024, 2024, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/fimmu.2024.1135490

Complement Factor H-Related Proteins FHR1 and FHR5 Interact With Extracellular Matrix Ligands, Reduce Factor H Regulatory Activity and Enhance Complement Activation.

Autori: Alexandra Papp; Krisztián Papp; Barbara Uzonyi; Marcell Cserhalmi; Ádám I. Csincsi; Zsóka Szabó; Zsófia Bánlaki; David Ermert; Zoltán Prohászka; Anna Erdei; Viviana P. Ferreira; Anna M. Blom; Mihály Józsi
Pubblicato in: Frontiers in Immunology, Numero 13, 2022, ISSN 1664-3224
Editore: Frontiers Media S.A.
DOI: 10.3389/fimmu.2022.845953

Editorial: Updates on the complement system in kidney diseases

Autori: Bulla R., Józsi M
Pubblicato in: Frontiers in Immunology, Numero 14, 2023, ISSN 1664-3224
Editore: Frontiers Media S.A.
DOI: 10.3389/fimmu.2023.1196487

Factor H-related 2 levels dictate FHR dimer composition

Autori: Bert R. J. Veuskens, Mieke C. Brouwer, Gerard van Mierlo, Judy Geissler, Karin van Leeuwen, Maaike Derlagen, Nadia C. H. Keijzer, Mark Hoogenboezem, Taco W. Kuijpers, Richard B. Pouw
Pubblicato in: Scientific Reports, Numero 15, 2025, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-025-94064-4

Autoantibodies Against Factor B and Factor H Without Pathogenic Effects in a Patient with Immune Complex-Mediated Membranoproliferative Glomerulonephritis

Autori: Alexandra T. Matola, Dorottya Csuka, Ágnes Szilágyi, Michael Rudnicki, Zoltán Prohászka, Mihály Józsi, Barbara Uzonyi
Pubblicato in: Biomedicines, Numero 13, 2025, Pagina/e 648, ISSN 2227-9059
Editore: MDPI AG
DOI: 10.3390/biomedicines13030648

Multiplexed electrochemical liposomes applied to the detection of nucleic acids for Influenza A, Influenza B and SARS-CoV-2

Autori: Florian Gerstl, Michael Loessl, Veronika Borggraefe, Antje J. Baeumner
Pubblicato in: Analytical and Bioanalytical Chemistry, Numero 416, 2024, Pagina/e 3487-3500, ISSN 1618-2642
Editore: Springer Verlag
DOI: 10.1007/s00216-024-05145-8

Decreased complement 4 and interleukin-10 as biomarkers in aqueous humour for non-exudative age-related macular degeneration: a case control study

Autori: Juliane Schikora, Aaron Dort, Hannah N. Wolf, Mihály Józsi, Richard B. Pouw, Thomas Bertelmann, Dirk Bahlmann, Christian van Oterendorp, Nicolas Feltgen, Hans Hoerauf, Diana Pauly, Jannis Klemming
Pubblicato in: Journal of Translational Medicine, Numero 23, 2025, ISSN 1479-5876
Editore: BioMed Central
DOI: 10.1186/s12967-024-05909-x

The Factor H protein family: The switchers of the complement alternative pathway

Autori: Laura Lucientes‐Continente; Bárbara Márquez‐Tirado; Elena Goicoechea de Jorge
Pubblicato in: Immunological Reviews, Numero 313(1), 2023, Pagina/e 25-45, ISSN 0105-2896
Editore: Blackwell Publishing Inc.
DOI: 10.1111/imr.13166

Development and characterization of novel ELISAs for the specific quantification of the factor H-related proteins 2, 3, 4 and 5

Autori: Mara van Rossum, Bert R.J. Veuskens, Mieke C. Brouwer, Gerard van Mierlo, Laura Lucientes-Continente, Elena Goicoechea de Jorge, Barbara Uzonyi, Alexandra T. Matola, Mihály Józsi, Günter Müller, Anita M. Meter-Arkema, Felix Poppelaars, Diana Pauly, Richard B. Pouw, Erik J.M. Toonen
Pubblicato in: Journal of Innate Immunity, 2025, Pagina/e 1-24, ISSN 1662-811X
Editore: Karger AG
DOI: 10.1159/000545139

The Contribution of Complement to the Pathogenesis of IgA Nephropathy: Are Complement-Targeted Therapies Moving from Rare Disorders to More Common Diseases?

Autori: Felix Poppelaars; Bernardo Faria; Wilhelm Schwaeble; Mohamed R. Daha
Pubblicato in: Journal of Clinical Medicine, Numero Vol 10, Iss 4715, p 4715 (2021), 2021, ISSN 2077-0383
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.17863/cam.77005

Editorial: Function and Dysfunction of Complement Factor H

Autori: Mihály Józsi, Pauli Nigel Barlow and Seppo Meri
Pubblicato in: Frontiers in Immunology, Numero 12, 2022, ISSN 1664-3224
Editore: Frontiers S.A.
DOI: 10.3389/fimmu.2021.831044

Factor H-Related Protein 1 Drives Disease Susceptibility and Prognosis in C3 Glomerulopathy.

Autori: Bárbara Márquez-Tirado; Josué Gutiérrez-Tenorio; Agustín Tortajada; Laura Lucientes Continente; Fernando Caravaca-Fontán; Talat H. Malik; Raquel Roldán Montero; Sandra Elías; Ana Saiz Gonzalez; Gema Fernández-Juarez; Pilar Sánchez-Corral; Matthew C. Pickering; Manuel Praga; Santiago Rodríguez de Córdoba; Elena Goicoechea de Jorge
Pubblicato in: Journal of the American Society of Nephrology, Numero Jun;33(6), 2022, Pagina/e 1137-1153, ISSN 1046-6673
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1681/asn.2021101318

Evaluating the clinical utility of measuring levels of factor H and the related proteins

Autori: Pratiti Banerjee; Bert R.J. Veuskens; Elena Goicoechea de Jorge; Mihály Józsi; Antje J. Baeumner; Mark-Steven Steiner; Richard B. Pouw; Erik J.M. Toonen; Diana Pauly; Felix Poppelaars
Pubblicato in: Molecular Immunology, Numero 151, 2022, ISSN 0161-5890
Editore: Pergamon Press
DOI: 10.1016/j.molimm.2022.08.010

The Factor H protein family: The switchers of the complement alternative pathway

Autori: Laura Lucientes‐Continente, Bárbara Márquez‐Tirado, Elena Goicoechea de Jorge
Pubblicato in: Immunological Reviews, Numero 313, 2023, Pagina/e 25-45, ISSN 0105-2896
Editore: Blackwell Publishing Inc.
DOI: 10.1111/imr.13166

Prognostic significance of serum complement activation, neutrophil extracellular traps and extracellular DNA in newly diagnosed epithelial ovarian cancer

Autori: Jason Ricciuti, Qian Liu, A.N.M. Nazmul H. Khan, Janine M. Joseph, Bert Veuskens, Thejaswini Giridharan, Sora Suzuki, Tiffany Emmons, Michael Yaffe, Taco W. Kuijpers, Ilse Jongerius, Mieke Brouwer, Richard B. Pouw, Kunle Odunsi, Peter Frederick, Katherine LaVigne Mager, Shashikant Lele, Nicole Gaulin, Christiane Hakim, Robert P. Edwards, Alexander B. Olawaiye, Paniti Sukamanovich, Sarah Taylor, Es
Pubblicato in: Gynecologic Oncology, Numero 193, 2025, Pagina/e 49-57, ISSN 0090-8258
Editore: Academic Press
DOI: 10.1016/j.ygyno.2024.12.006

Common haplotypes within the chromosome 1q31.3 region determine systemic concentrations of the entire complement factor H protein family

Autori: Bert R.J. Veuskens, Mara Van Rossum, Emi Cattenstart, Mieke C. Brouwer, Gerard van Mierlo, Judy Geissler, Karin van Leeuwen, Jin Liu, Robert A. Anstadt, Burt T. Richards, Gregory S. Hageman, Taco W. Kuijpers, Erik J.M. Toonen, Richard B. Pouw
Pubblicato in: Journal of Innate Immunity, 2025, Pagina/e 1-26, ISSN 1662-811X
Editore: Karger AG
DOI: 10.1159/000545342

Factor H–related proteins and their associated disorders

Autori: Mihály Józsi, Barbara Uzonyi
Pubblicato in: Journal of Allergy and Clinical Immunology, 2025, ISSN 0091-6749
Editore: Mosby Inc.
DOI: 10.1016/j.jaci.2025.05.024

Encapsulants Affect Liposome Surface Interactions with Biological Systems

Autori: Clemens Spitzenberg, Christoph Bruckschlegel, Ferdinand Holzhausen, Sebastian Boesl‐Bichlmeier, Coralie Pasquier, Patrick Nuernberger, Pierre Bauduin, Antje J. Baeumner
Pubblicato in: Small, 2025, ISSN 1613-6810
Editore: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202505312

Complement Factor H Family Proteins Modulate Monocyte and Neutrophil Granulocyte Functions

Autori: Éva Kárpáti, Mariann Kremlitzka, Noémi Sándor, Dávid Hajnal, Andrea E. Schneider and Mihály Józsi
Pubblicato in: Frontiers in Immunology, Numero 12:660852, 2021, ISSN 1664-3224
Editore: Frontiers Media S.A.
DOI: 10.3389/fimmu.2021.660852

Pitfalls in complement analysis: A systematic literature review of assessing complement activation

Autori: Ricardo J. M. G. E. Brandwijk, Marloes A. H. M. Michels, Mara van Rossum, Aline H. de Nooijer, Per H. Nilsson, Wieke C. C. de Bruin and Erik J. M. Toonen
Pubblicato in: Frontiers in Immunology, Numero 13, 2022, ISSN 1664-3224
Editore: Frontiers S.A.
DOI: 10.3389/fimmu.2022.1007102

Complement Factor H-Related Proteins FHR1 and FHR5 Interact With Extracellular Matrix Ligands, Reduce Factor H Regulatory Activity and Enhance Complement Activation

Autori: Alexandra Papp, Krisztián Papp, Barbara Uzonyi, Marcell Cserhalmi, Ádám I. Csincsi, Zsóka Szabó, Zsófia Bánlaki, David Ermert, Zoltán Prohászka, Anna Erdei, Viviana P. Ferreira, Anna M. Blom, Mihály Józsi
Pubblicato in: Frontiers in Immunology, Numero 13, 2023, Pagina/e 845953, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2022.845953

Factor H–Related Protein 1 Drives Disease Susceptibility and Prognosis in C3 Glomerulopathy

Autori: Bárbara Márquez-Tirado, Josué Gutiérrez-Tenorio, Agustín Tortajada, Laura Lucientes Continente, Fernando Caravaca-Fontán, Talat H. Malik, Raquel Roldán Montero, Sandra Elías, Ana Saiz Gonzalez, Gema Fernández-Juarez, Pilar Sánchez-Corral, Matthew C. Pickering, Manuel Praga, Santiago Rodríguez de Córdoba, Elena Goicoechea de Jorge
Pubblicato in: Journal of the American Society of Nephrology, Numero 33, 2024, Pagina/e 1137-1153, ISSN 1046-6673
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1681/asn.2021101318

Complement Factor H-Related 3 Enhanced Inflammation and Complement Activation in Human RPE Cells

Autori: Nicole Schäfer, Anas Rasras, Delia M. Ormenisan, Sabine Amslinger, Volker Enzmann, Herbert Jägle and Diana Pauly
Pubblicato in: Frontiers in Immunology, Numero 12:769242, 2021, ISSN 1664-3224
Editore: Frontiers Media S.A
DOI: 10.3389/fimmu.2021.769242

Functional and structural characterization of mouse Factor H-related B protein unveils a novel dimerization domain shared by FHR-B and FH

Autori: Adrián Martín-Ambrosio Doménech, Silvia González Sanz, Bárbara Márquez Tirado, Lucia Juana-López, Elena Goicoechea de Jorge, Santiago Rodríguez de Córdoba, Héctor Martín Merinero
Pubblicato in: Frontiers in Immunology, Numero 16, 2025, ISSN 1664-3224
Editore: Frontiers Research Foundation
DOI: 10.3389/fimmu.2025.1522651