Neural Active Visual Prosthetics for Restoring Function

Informations projet

NeuraViPeR

N° de convention de subvention: 899287

DOI

10.3030/899287

Projet clôturé

Date de signature de la CE 28 Mai 2020

Date de début 1 Septembre 2020

Date de fin 28 Février 2025

Financé au titre de

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Coût total

€ 3 998 681,25

Contribution de l’UE

€ 3 998 681,25

Coordonné par

UNIVERSITAT ZURICH
Switzerland

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (7)

Report & pipeline for self-calibrating stimulation

This report describes the opensource software which will be used for MLbased phosphene vision Opensource software will be disseminated via a publicly accessible repository

Report on flexible shaft electrodes

Report the longterm stability stimulation efficacy and biocompatibility of flexible probes during in vivo applications in the visual cortex of rodents The analysis is based on monitoring tissue gliosis impedance stability and twophoton calcium imaging to access neural activity

Network simulation study

Report of study of the initial AI networks of WP4 targeting the hardware FPGA implementations and the impact of reduced bit precision of weights and activations

Hardware refinement

Report on the system design in the closed loop setup taking into account the bandwidth requirements of the stimulation/recording module.

Report on enhancing perceptual experience

Report describing the performance of the artificial vision system as evaluated with sighted subjects in virtual reality setups. The open-access report will be submitted to a conference or journal for academic dissemination.

Report on self-calibrating neural stimulation

This report describes adaptive algorithms that automatically determine optimal stimulation parameters to induce each phosphene The openaccess report will be submitted to a conference or journal for academic dissemination

Report on microstimulation in sulci of monkeys

Report of the in vivo application of flexible probes and ASIC from WP2, with probes implanted into the lunate sulcus of non-human primates to elicit phosphene vision by electrical microstimulation. The analysis will evaluate long-term safety, biocompatibility and surgical protocols.

Demonstrators, pilots, prototypes (3)

Demo of algorithms in closed-loop setup

Integrates the algorithmic developments into a fully functional closed-loop system for demonstrator in WP3. The closed-loop system will consist of a VR helmet which will visualise the output of the phosphene vision system. The system can be used to simulate phosphene vision in seeing subjects and drive phosphene vision in blind subjects.

Long term stable fully in vivo validated 1024 channel system

Flexible stackable probe assembly with 1024 individually addressable electrodes implanted and able to generate stably generate phosphenes with spatial precision and stably record single units over time.

Complementary metal oxide semiconductor interconnected and stackable (up to 4) multi-shaft 128 channel probes

Flexible probes interconnected with stackable interface, encapsulated and ready for implantation.

Open Research Data Pilot (1)

Data management plan

Description of the data management plan for the collected data during the project

Websites, patent fillings, videos etc. (1)

Project website

Report on project website which will also be used to update the public on the NeuraViPeR project

Publications

Peer reviewed articles (28)

The direct and indirect pathways of the basal ganglia antagonistically influence cortical activity and perceptual decisions

Auteurs: Enny H. van Beest, Mohammed A.O. Abdelwahab, J. Leonie Cazemier, Chrysiida Baltira, M. Cassandra Maes, Brandon D. Peri, Matthew W. Self, Ingo Willuhn, Pieter R. Roelfsema
Publié dans: iScience, Numéro 27, 2024, Page(s) 110753, ISSN 2589-0042
Éditeur: Cell Press
DOI: 10.1016/j.isci.2024.110753

An In-Silico Framework for Modeling Optimal Control of Neural Systems

Auteurs: Rueckauer, B. and van Gerven, M.
Publié dans: Frontiers in Neuroscience, Numéro Continuous, 2023, ISSN 1662-4548
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fnins.2023.1141884

Towards biologically plausible phosphene simulation for the differentiable optimization of visual cortical prostheses

Auteurs: Maureen van der Grinten, Jaap de Ruyter van Steveninck, Antonio Lozano, Laura Pijnacker, Bodo Rueckauer, Pieter Roelfsema, Marcel van Gerven, Richard van Wezel, Umut Güçlü, Yağmur Güçlütürk
Publié dans: eLife, Numéro 13, 2024, ISSN 2050-084X
Éditeur: eLife Sciences Publications
DOI: 10.7554/elife.85812

Optimization of Neuroprosthetic Vision via End-to-End Deep Reinforcement Learning

Auteurs: Küçükoğlu, B., Rueckauer, B., Ahmad, N., van Steveninck, J. R., Güçlü, U., and van Gerven, M.
Publié dans: International Journal of Neural Systems, Numéro Quarterly, 2022, ISSN 0129-0657
Éditeur: World Scientific Publishing Co
DOI: 10.1142/s0129065722500526

Gaze-contingent processing improves mobility, scene recognition and visual search in simulated head-steered prosthetic vision

Auteurs: Jaap de Ruyter van Steveninck, Mo Nipshagen, Marcel van Gerven, Umut Güçlü, Yağmur Güçlüturk, Richard van Wezel
Publié dans: Journal of Neural Engineering, Numéro 21, 2024, Page(s) 026037, ISSN 1741-2560
Éditeur: Institute of Physics Publishing
DOI: 10.1088/1741-2552/ad357d

Machine learning enables non-Gaussian investigation of changes to peripheral nerves related to electrical stimulation

Auteurs: Andres W. Morales, Jinze Du, David J. Warren, Eduardo Fernández-Jover, Gema Martinez-Navarrete, Jean-Marie C. Bouteiller, Douglas C. McCreery, Gianluca Lazzi
Publié dans: Scientific Reports, Numéro 14, 2024, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-024-53284-w

Brain connectivity changes in response to cortical electrical stimulation in blind neuroprosthesis users

Auteurs: Fernando Daniel Farfán, Leili Soo, Fabrizio Grani, María Dolores Grima-Murcia, Eduardo Fernández
Publié dans: Cerebral Cortex, Numéro 35, 2025, ISSN 1047-3211
Éditeur: Oxford University Press
DOI: 10.1093/cercor/bhaf075

Solving the binding problem: assemblies form when neurons enhance their firing rate – they don’t need to oscillate or synchronize

Auteurs: Roelfsema, P.R
Publié dans: Neuron, Numéro Monthly, 2023, ISSN 0896-6273
Éditeur: Cell Press
DOI: 10.1016/j.neuron.2023.03.016

Efficient Deep Reinforcement Learning with Predictive Processing Proximal Policy Optimization

Auteurs: Burcu Küçükoğlu, Walraaf Borkent, Bodo Rueckauer, Nasir Ahmad, Umut Güçlü, Marcel van Gerven
Publié dans: Neurons, Behavior, Data analysis, and Theory, 2024, ISSN 2690-2664
Éditeur: NBDT
DOI: 10.51628/001c.123366

1024-channel electrophysiological recordings in macaque V1 and V4 during resting state

Auteurs: Chen X*, Morales-Gregorio A*, Sridhar S, Sprenger J, van Albada SJ, Grün S, Roelfsema PR.
Publié dans: Scientific Data, Numéro continuous, 2022, ISSN 2052-4463
Éditeur: Springer Nature
DOI: 10.1038/s41597-022-01180-1

Pronouns reactivate conceptual representations in human hippocampal neurons

Auteurs: D. E. Dijksterhuis, M. W. Self, J. K. Possel, J. C. Peters, E. C. W. van Straaten, S. Idema, J. C. Baaijen, S. M. A. van der Salm, E. J. Aarnoutse, N. C. E. van Klink, P. van Eijsden, S. Hanslmayr, R. Chelvarajah, F. Roux, L. D. Kolibius, V. Sawlani, D. T. Rollings, S. Dehaene, P. R. Roelfsema
Publié dans: Science, Numéro 385, 2024, Page(s) 1478-1484, ISSN 0036-8075
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/science.adr2813

Toward a personalized closed-loop stimulation of the visual cortex: Advances and challenges

Auteurs: Grani, F., Soto-Sánchez, C., Fimia, A., & Fernández, E.
Publié dans: Frontiers in Cellular Neuroscience, Numéro Continuous, 2022, ISSN 1662-5102
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fncel.2022.1034270

Point-SPV: end-to-end enhancement of object recognition in simulated prosthetic vision using synthetic viewing points

Auteurs: Ashkan Nejad, Burcu Küçükoǧlu, Jaap de Ruyter van Steveninck, Sandra Bedrossian, Joost Heutink, Gera A. de Haan, Frans W. Cornelissen, Marcel van Gerven
Publié dans: Frontiers in Human Neuroscience, Numéro 19, 2025, ISSN 1662-5161
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fnhum.2025.1549698

Advances and challenges in the development of visual prostheses

Auteurs: Eduardo Fernandez, Jose Antonio Robles
Publié dans: PLOS Biology, Numéro 22, 2024, Page(s) e3002896, ISSN 1545-7885
Éditeur: PLOS
DOI: 10.1371/journal.pbio.3002896

Impact of transcranial Direct Current Stimulation on stereoscopic vision and retinal structure in adult amblyopic rodents

Auteurs: Gema Martinez-Navarrete, Sergio Castaño-Castaño, Miguel Morales-Navas, Francisco Nieto-Escámez, Fernando Sánchez-Santed, Eduardo Fernandez
Publié dans: Eye and Brain, Numéro Volume 16, 2024, Page(s) 75-88, ISSN 1179-2744
Éditeur: Taylor and Francis
DOI: 10.2147/eb.s474573

V1 neurons are tuned to perceptual borders in natural scenes

Auteurs: Paolo Papale, Wietske Zuiderbaan, Rob R. M. Teeuwen, Amparo Gilhuis, Matthew W. Self, Pieter R. Roelfsema, Serge O. Dumoulin
Publié dans: Proceedings of the National Academy of Sciences, Numéro 121, 2024, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.2221623121

Comparison of electrical microstimulation artifact removal methods for high-channel-count prostheses

Auteurs: Feng Wang, Xing Chen, Pieter R. Roelfsema
Publié dans: Journal of Neuroscience Methods, Numéro 408, 2024, Page(s) 110169, ISSN 0165-0270
Éditeur: Elsevier BV
DOI: 10.1016/j.jneumeth.2024.110169

An extensive dataset of spiking activity to reveal the syntax of the ventral stream

Auteurs: Paolo Papale, Feng Wang, Matthew W. Self, Pieter R. Roelfsema
Publié dans: Neuron, Numéro 113, 2025, Page(s) 539-553.e5, ISSN 0896-6273
Éditeur: Cell Press
DOI: 10.1016/j.neuron.2024.12.003

Multilayer Arrays for Neurotechnology Applications (MANTA): Chronically Stable Thin-Film Intracortical Implants

Auteurs: C. Boehler, M. Vomero, M. Soula, M. Vöröslakos, M. Porto Cruz, R. Liljemalm, G. Buzsaki, T. Stieglitz, M. Asplund
Publié dans: Advanced Science, Numéro Monthly, 2023, ISSN 2198-3844
Éditeur: Wiley
DOI: 10.1002/advs.202207576

Time stability and connectivity analysis with an intracortical 96-channel microelectrode array inserted in human visual cortex

Auteurs: Grani, F., Soto-Sánchez, C., Farfan, F. D., Alfaro, A., Grima, M. D., Doblado, A. R., & Fernández, E
Publié dans: Journal of Neural Engineering, Numéro Quarterly, 2022, ISSN 1741-2560
Éditeur: Institute of Physics Publishing
DOI: 10.1088/1741-2552/ac801d

An integrative, multiscale view on neural theories of consciousness

Auteurs: Johan F. Storm, P. Christiaan Klink, Jaan Aru, Walter Senn, Rainer Goebel, Andrea Pigorini, Pietro Avanzini, Wim Vanduffel, Pieter R. Roelfsema, Marcello Massimini, Matthew E. Larkum, Cyriel M.A. Pennartz
Publié dans: Neuron, Numéro 112, 2024, Page(s) 1531-1552, ISSN 0896-6273
Éditeur: Cell Press
DOI: 10.1016/j.neuron.2024.02.004

Neuronal Waveform Classification in Multielectrode Recordings Using Machine Learning Techniques and Multidimensional Analysis

Auteurs: Rocio Lopez-Peco, Mikel Val-Calvo, Cristina Soto-Sanchez, Adrian Villamarin-Ortiz, Gloria Ruiz-Boix, Jose Manuel Ferrandez-Vicente, Eduardo Fernandez
Publié dans: International Journal of Neural Systems, 2025, ISSN 0129-0657
Éditeur: World Scientific Publishing Co
DOI: 10.1142/s0129065725500315

Flexible Polymer Electrodes for Stable Prosthetic Visual Perception in Mice

Auteurs: Corinne Orlemann, Christian Boehler, Roxana N. Kooijmans, Bingshuo Li, Maria Asplund, Pieter R. Roelfsema
Publié dans: Advanced Healthcare Materials, Numéro 13, 2024, ISSN 2192-2640
Éditeur: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202304169

Recording Quality Is Systematically Related to Electrode Impedance

Auteurs: Christopher M. Lewis, Christian Boehler, Rickard Liljemalm, Pascal Fries, Thomas Stieglitz, Maria Asplund
Publié dans: Advanced Healthcare Materials, Numéro Continuous, 2024, ISSN 2192-2640
Éditeur: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202303401

Chronic stability of a neuroprosthesis comprising multiple adjacent Utah arrays in monkeys

Auteurs: X. Chen, F: Wang, R. Kooijmans, P.C. Klink, C. Boehler, M. Asplund, P.R. Roelfsema
Publié dans: Journal of Neural Engineering, Numéro Quarterly, 2023, ISSN 1741-2560
Éditeur: Institute of Physics Publishing
DOI: 10.1088/1741-2552/ace07e

Visual percepts evoked with an intracortical 96-channel microelectrode array inserted in human occipital cortex

Auteurs: Fernandez, E., Alfaro, A., Soto-Sanchez, C., Gonzalez-Lopez, P., Lozano, A., Peña, S., Rodil, A., Gomez, B., Chez, X., Roefsema, P., Rolston, J., Davis, T., Normann, RA.
Publié dans: Journal of Clinical Investigation, Numéro continuous, 2021, ISSN 0021-9738
Éditeur: American Society for Clinical Investigation
DOI: 10.1172/jci151331

Electrochemical impedance spectroscopy in vivo for neurotechnology and bioelectronics

Auteurs: Hazelgrove, B., Matter, L., Raos, B., Harland, B., Cheng, L., Asplund, M., Svirskis, D.
Publié dans: Nature Reviews Electrical Engineering, Numéro Continuous, 2025, Page(s) 110–124, ISSN 2948-1201
Éditeur: Nature
DOI: 10.1038/s44287-024-00126-6

Engineering strategies towards overcoming bleeding and glial scar formation around neural probes

Auteurs: Otte E, Vlachos A, Asplund M
Publié dans: Cell and Tissue Research, Numéro 4, 2022, ISSN 0302-766X
Éditeur: Springer Verlag
DOI: 10.1007/s00441-021-03567-9

Other (3)

End-to-end Learning of Safe Stimulation Parameters for Cortical Neuroprosthetic Vision

Auteurs: Burcu Küçükoğlu, Bodo Rueckauer, Jaap de Ruyter van Steveninck, Maureen van der Grinten, Yağmur Güçlütürk, Pieter R. Roelfsema, Umut Güçlü, Marcel van Gerven
Publié dans: BioArxiv, Numéro Continuously, 2025
Éditeur: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.01.23.634543

Bayesian optimization of cortical neuroprosthetic vision using perceptual feedback

Auteurs: Burcu Kucukoglu, Leili Soo, David Leeftink, Fabrizio Grani, Cristina Soto Sanchez, Umut Guclu, Marcel van Gerven, Eduardo Fernandez
Publié dans: 2025
Éditeur: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.01.24.634528

Decorrelated Soft Actor-Critic for Efficient Deep Reinforcement Learning

Auteurs: Burcu Küçükoğlu, Sander Dalm, Marcel van Gerven
Publié dans: Arxiv, Numéro Continuous, 2025
Éditeur: Cornell University
DOI: 10.48550/arxiv.2501.19133

Conference proceedings (9)

A 128-channel real-time VPDNN stimulation system for a visual cortical neuroprosthesis

Auteurs: Hasan Mohamed, Bogdan Raducanu, Ilya Kiselev, Zuowen Wang, Burcu Küçükoğlu, Bodo Rueckauer, Marcel van Gerven, Carolina Mora Lopez, Shih-Chii Liu
Publié dans: 2023 IEEE Biomedical Circuits and Systems Conference (BioCAS), 2024, Page(s) 1-5
Éditeur: IEEE
DOI: 10.1109/biocas58349.2023.10389055

New Wafer-Level Fabrication of Ultrathin Silicon Insertion Shuttles for Flexible Neural Implants

Auteurs: K. Sharma, C. Boehler, M. Asplund, O. Paul, and P. Ruther
Publié dans: 2023 IEEE 36th International Conference on Micro Electro Mechanical Systems (MEMS), Numéro Annually, 2023
Éditeur: IEEE
DOI: 10.1109/mems49605.2023.10052581

Experiencing prosthetic vision with event-based sensors

Auteurs: Rückauer, B.J.; Gerven, M.A.J. van; Potok, T.E.; Schuman, C.
Publié dans: Proceedings of the International Conference on Neuromorphic Systems, Numéro Annually, 2022
Éditeur: Association for Computing Machinery (ACM)
DOI: 10.1145/3546790.3546813

Leveraging Recurrent Neural Networks for Predicting Motor Movements from Primate Motor Cortex Neural Recordings

Auteurs: Yuanxi Wang, Zuowen Wang, Shih-Chii Liu
Publié dans: 2024 IEEE Biomedical Circuits and Systems Conference (BioCAS), 2024, Page(s) 1-5
Éditeur: IEEE
DOI: 10.1109/biocas61083.2024.10798182

Lightweight semantic segmentation networks for real-time visual prosthesis applications

Auteurs: H. Wang, H. Mohamed, Z. Wang, B. Rueckauer, S-C. Liu
Publié dans: 2021 ICCV Workshop (The 1st Workshop on Video Scene Parsing in the Wild), Numéro 1, 2021, ISSN 2473-9944
Éditeur: IEEE Computer Society
DOI: 10.1109/iccvw54120.2021.00300

A 128-channel neural stimulation and recording ASIC for scalable cortical visual prosthesis

Auteurs: Bogdan C. Raducanu, Joan Aymerich, Wen-Yang Hsu, Patrick Hendrickx, Carolina Mora Lopez
Publié dans: ESSCIRC 2023- IEEE 49th European Solid State Circuits Conference (ESSCIRC), 2023, Page(s) 301-304
Éditeur: IEEE
DOI: 10.1109/esscirc59616.2023.10268749

Bio-inspired parameter reuse: Exploiting inter-frame representation similarity with recurrence for accelerating temporal visual processing

Auteurs: Wang, Zuowen; Cheng, Longbiao; Ott, Joachim; Moure, Pehuen; Liu, Shih-Chii
Publié dans: Proceedings of Machine Learning Research, Numéro 3, 2024, Page(s) 209-222
Éditeur: JMLR
DOI: 10.5167/uzh-254310

Fast temporal decoding from large-scale neural recordings in monkey visual cortex

Auteurs: Hadorn, J.*, Wang, Z.*, Rueckauer, B., Chen, X., Roelfsema, P., Liu, S.-C
Publié dans: NeurIPS 2022 Workshop on Shared Visual Representations in Human & Machine Intelligence, Numéro Annually, 2022
Éditeur: NeurIPS
DOI: 10.3929/ethz-b-000595073

Hierarchical Bonding Yield Test Structure for Flexible High Channel-Count Neural Probes Interfacing ASIC Chips

Auteurs: M. C. Odenthal, V. Claar, O. Paul, and P. Ruther
Publié dans: 2023 IEEE 36th International Conference on Micro Electro Mechanical Systems (MEMS), Numéro Annually, 2023
Éditeur: IEEE
DOI: 10.1109/mems49605.2023.10052500