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Neural Active Visual Prosthetics for Restoring Function

Livrables

Report & pipeline for self-calibrating stimulation

This report describes the opensource software which will be used for MLbased phosphene vision Opensource software will be disseminated via a publicly accessible repository

Report on flexible shaft electrodes

Report the longterm stability stimulation efficacy and biocompatibility of flexible probes during in vivo applications in the visual cortex of rodents The analysis is based on monitoring tissue gliosis impedance stability and twophoton calcium imaging to access neural activity

Network simulation study

Report of study of the initial AI networks of WP4 targeting the hardware FPGA implementations and the impact of reduced bit precision of weights and activations

Report on self-calibrating neural stimulation

This report describes adaptive algorithms that automatically determine optimal stimulation parameters to induce each phosphene The openaccess report will be submitted to a conference or journal for academic dissemination

Data management plan

Description of the data management plan for the collected data during the project

Project website

Report on project website which will also be used to update the public on the NeuraViPeR project

Publications

An In-Silico Framework for Modeling Optimal Control of Neural Systems

Auteurs: Rueckauer, B. and van Gerven, M.
Publié dans: Frontiers in Neuroscience, Numéro Continuous, 2023, ISSN 1662-4548
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fnins.2023.1141884

Optimization of Neuroprosthetic Vision via End-to-End Deep Reinforcement Learning

Auteurs: Küçükoğlu, B., Rueckauer, B., Ahmad, N., van Steveninck, J. R., Güçlü, U., and van Gerven, M.
Publié dans: International Journal of Neural Systems, Numéro Quarterly, 2022, ISSN 0129-0657
Éditeur: World Scientific Publishing Co
DOI: 10.1142/s0129065722500526

Solving the binding problem: assemblies form when neurons enhance their firing rate – they don’t need to oscillate or synchronize

Auteurs: Roelfsema, P.R
Publié dans: Neuron, Numéro Monthly, 2023, ISSN 0896-6273
Éditeur: Cell Press
DOI: 10.1016/j.neuron.2023.03.016

1024-channel electrophysiological recordings in macaque V1 and V4 during resting state

Auteurs: Chen X*, Morales-Gregorio A*, Sridhar S, Sprenger J, van Albada SJ, Grün S, Roelfsema PR.
Publié dans: Scientific Data, Numéro continuous, 2022, ISSN 2052-4463
Éditeur: Springer Nature
DOI: 10.1038/s41597-022-01180-1

Toward a personalized closed-loop stimulation of the visual cortex: Advances and challenges

Auteurs: Grani, F., Soto-Sánchez, C., Fimia, A., & Fernández, E.
Publié dans: Frontiers in Cellular Neuroscience, Numéro Continuous, 2022, ISSN 1662-5102
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fncel.2022.1034270

Multilayer Arrays for Neurotechnology Applications (MANTA): Chronically Stable Thin-Film Intracortical Implants

Auteurs: C. Boehler, M. Vomero, M. Soula, M. Vöröslakos, M. Porto Cruz, R. Liljemalm, G. Buzsaki, T. Stieglitz, M. Asplund
Publié dans: Advanced Science, Numéro Monthly, 2023, ISSN 2198-3844
Éditeur: Wiley
DOI: 10.1002/advs.202207576

Time stability and connectivity analysis with an intracortical 96-channel microelectrode array inserted in human visual cortex

Auteurs: Grani, F., Soto-Sánchez, C., Farfan, F. D., Alfaro, A., Grima, M. D., Doblado, A. R., & Fernández, E
Publié dans: Journal of Neural Engineering, Numéro Quarterly, 2022, ISSN 1741-2560
Éditeur: Institute of Physics Publishing
DOI: 10.1088/1741-2552/ac801d

Chronic stability of a neuroprosthesis comprising multiple adjacent Utah arrays in monkeys

Auteurs: X. Chen, F: Wang, R. Kooijmans, P.C. Klink, C. Boehler, M. Asplund, P.R. Roelfsema
Publié dans: Journal of Neural Engineering, Numéro Quarterly, 2023, ISSN 1741-2560
Éditeur: Institute of Physics Publishing
DOI: 10.1088/1741-2552/ace07e

Visual percepts evoked with an intracortical 96-channel microelectrode array inserted in human occipital cortex

Auteurs: Fernandez, E., Alfaro, A., Soto-Sanchez, C., Gonzalez-Lopez, P., Lozano, A., Peña, S., Rodil, A., Gomez, B., Chez, X., Roefsema, P., Rolston, J., Davis, T., Normann, RA.
Publié dans: Journal of Clinical Investigation, Numéro continuous, 2021, ISSN 0021-9738
Éditeur: American Society for Clinical Investigation
DOI: 10.1172/jci151331

Engineering strategies towards overcoming bleeding and glial scar formation around neural probes

Auteurs: Otte E, Vlachos A, Asplund M
Publié dans: Cell and Tissue Research, Numéro 4, 2022, ISSN 0302-766X
Éditeur: Springer Verlag
DOI: 10.1007/s00441-021-03567-9

Biologically plausible phosphene simulation for the differentiable optimization of visual cortical prostheses

Auteurs: van der Grinten, M. L., de Ruyter van Steveninck, J., Lozano, A., Pijnacker, L., Rueckauer, B., Roelfsema, P., van Gerven, M., van Wezel, R., Güçlü, U., Güçlütürk, Y.
Publié dans: bioRxiv, Numéro continuous, 2022, ISSN 2692-8205
Éditeur: Cold Spring Harbor Labs
DOI: 10.1101/2022.12.23.521749

New Wafer-Level Fabrication of Ultrathin Silicon Insertion Shuttles for Flexible Neural Implants

Auteurs: K. Sharma, C. Boehler, M. Asplund, O. Paul, and P. Ruther
Publié dans: 2023 IEEE 36th International Conference on Micro Electro Mechanical Systems (MEMS), Numéro Annually, 2023
Éditeur: IEEE
DOI: 10.1109/mems49605.2023.10052581

Experiencing prosthetic vision with event-based sensors

Auteurs: Rückauer, B.J.; Gerven, M.A.J. van; Potok, T.E.; Schuman, C.
Publié dans: Proceedings of the International Conference on Neuromorphic Systems, Numéro Annually, 2022
Éditeur: Association for Computing Machinery (ACM)
DOI: 10.1145/3546790.3546813

Lightweight semantic segmentation networks for real-time visual prosthesis applications

Auteurs: H. Wang, H. Mohamed, Z. Wang, B. Rueckauer, S-C. Liu
Publié dans: 2021 ICCV Workshop (The 1st Workshop on Video Scene Parsing in the Wild), Numéro 1, 2021, ISSN 2473-9944
Éditeur: IEEE Computer Society
DOI: 10.1109/iccvw54120.2021.00300

Fast temporal decoding from large-scale neural recordings in monkey visual cortex

Auteurs: Hadorn, J.*, Wang, Z.*, Rueckauer, B., Chen, X., Roelfsema, P., Liu, S.-C
Publié dans: NeurIPS 2022 Workshop on Shared Visual Representations in Human & Machine Intelligence, Numéro Annually, 2022
Éditeur: NeurIPS
DOI: 10.3929/ethz-b-000595073

Hierarchical Bonding Yield Test Structure for Flexible High Channel-Count Neural Probes Interfacing ASIC Chips

Auteurs: M. C. Odenthal, V. Claar, O. Paul, and P. Ruther
Publié dans: 2023 IEEE 36th International Conference on Micro Electro Mechanical Systems (MEMS), Numéro Annually, 2023
Éditeur: IEEE
DOI: 10.1109/mems49605.2023.10052500

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