Neural Active Visual Prosthetics for Restoring Function

Project Information

NeuraViPeR

Grant agreement ID: 899287

DOI

10.3030/899287

Project closed

EC signature date 28 May 2020

Start date 1 September 2020

End date 28 February 2025

Funded under

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Total cost

€ 3 998 681,25

EU contribution

€ 3 998 681,25

Coordinated by

UNIVERSITAT ZURICH
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (7)

Report & pipeline for self-calibrating stimulation

This report describes the opensource software which will be used for MLbased phosphene vision Opensource software will be disseminated via a publicly accessible repository

Report on flexible shaft electrodes

Report the longterm stability stimulation efficacy and biocompatibility of flexible probes during in vivo applications in the visual cortex of rodents The analysis is based on monitoring tissue gliosis impedance stability and twophoton calcium imaging to access neural activity

Network simulation study

Report of study of the initial AI networks of WP4 targeting the hardware FPGA implementations and the impact of reduced bit precision of weights and activations

Hardware refinement

Report on the system design in the closed loop setup taking into account the bandwidth requirements of the stimulation/recording module.

Report on enhancing perceptual experience

Report describing the performance of the artificial vision system as evaluated with sighted subjects in virtual reality setups. The open-access report will be submitted to a conference or journal for academic dissemination.

Report on self-calibrating neural stimulation

This report describes adaptive algorithms that automatically determine optimal stimulation parameters to induce each phosphene The openaccess report will be submitted to a conference or journal for academic dissemination

Report on microstimulation in sulci of monkeys

Report of the in vivo application of flexible probes and ASIC from WP2, with probes implanted into the lunate sulcus of non-human primates to elicit phosphene vision by electrical microstimulation. The analysis will evaluate long-term safety, biocompatibility and surgical protocols.

Demonstrators, pilots, prototypes (3)

Demo of algorithms in closed-loop setup

Integrates the algorithmic developments into a fully functional closed-loop system for demonstrator in WP3. The closed-loop system will consist of a VR helmet which will visualise the output of the phosphene vision system. The system can be used to simulate phosphene vision in seeing subjects and drive phosphene vision in blind subjects.

Long term stable fully in vivo validated 1024 channel system

Flexible stackable probe assembly with 1024 individually addressable electrodes implanted and able to generate stably generate phosphenes with spatial precision and stably record single units over time.

Complementary metal oxide semiconductor interconnected and stackable (up to 4) multi-shaft 128 channel probes

Flexible probes interconnected with stackable interface, encapsulated and ready for implantation.

Open Research Data Pilot (1)

Data management plan

Description of the data management plan for the collected data during the project

Websites, patent fillings, videos etc. (1)

Project website

Report on project website which will also be used to update the public on the NeuraViPeR project

Publications

Peer reviewed articles (28)

The direct and indirect pathways of the basal ganglia antagonistically influence cortical activity and perceptual decisions

Author(s): Enny H. van Beest, Mohammed A.O. Abdelwahab, J. Leonie Cazemier, Chrysiida Baltira, M. Cassandra Maes, Brandon D. Peri, Matthew W. Self, Ingo Willuhn, Pieter R. Roelfsema
Published in: iScience, Issue 27, 2024, Page(s) 110753, ISSN 2589-0042
Publisher: Cell Press
DOI: 10.1016/j.isci.2024.110753

An In-Silico Framework for Modeling Optimal Control of Neural Systems

Author(s): Rueckauer, B. and van Gerven, M.
Published in: Frontiers in Neuroscience, Issue Continuous, 2023, ISSN 1662-4548
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnins.2023.1141884

Towards biologically plausible phosphene simulation for the differentiable optimization of visual cortical prostheses

Author(s): Maureen van der Grinten, Jaap de Ruyter van Steveninck, Antonio Lozano, Laura Pijnacker, Bodo Rueckauer, Pieter Roelfsema, Marcel van Gerven, Richard van Wezel, Umut Güçlü, Yağmur Güçlütürk
Published in: eLife, Issue 13, 2024, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.85812

Optimization of Neuroprosthetic Vision via End-to-End Deep Reinforcement Learning

Author(s): Küçükoğlu, B., Rueckauer, B., Ahmad, N., van Steveninck, J. R., Güçlü, U., and van Gerven, M.
Published in: International Journal of Neural Systems, Issue Quarterly, 2022, ISSN 0129-0657
Publisher: World Scientific Publishing Co
DOI: 10.1142/s0129065722500526

Gaze-contingent processing improves mobility, scene recognition and visual search in simulated head-steered prosthetic vision

Author(s): Jaap de Ruyter van Steveninck, Mo Nipshagen, Marcel van Gerven, Umut Güçlü, Yağmur Güçlüturk, Richard van Wezel
Published in: Journal of Neural Engineering, Issue 21, 2024, Page(s) 026037, ISSN 1741-2560
Publisher: Institute of Physics Publishing
DOI: 10.1088/1741-2552/ad357d

Machine learning enables non-Gaussian investigation of changes to peripheral nerves related to electrical stimulation

Author(s): Andres W. Morales, Jinze Du, David J. Warren, Eduardo Fernández-Jover, Gema Martinez-Navarrete, Jean-Marie C. Bouteiller, Douglas C. McCreery, Gianluca Lazzi
Published in: Scientific Reports, Issue 14, 2024, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-024-53284-w

Brain connectivity changes in response to cortical electrical stimulation in blind neuroprosthesis users

Author(s): Fernando Daniel Farfán, Leili Soo, Fabrizio Grani, María Dolores Grima-Murcia, Eduardo Fernández
Published in: Cerebral Cortex, Issue 35, 2025, ISSN 1047-3211
Publisher: Oxford University Press
DOI: 10.1093/cercor/bhaf075

Solving the binding problem: assemblies form when neurons enhance their firing rate – they don’t need to oscillate or synchronize

Author(s): Roelfsema, P.R
Published in: Neuron, Issue Monthly, 2023, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2023.03.016

Efficient Deep Reinforcement Learning with Predictive Processing Proximal Policy Optimization

Author(s): Burcu Küçükoğlu, Walraaf Borkent, Bodo Rueckauer, Nasir Ahmad, Umut Güçlü, Marcel van Gerven
Published in: Neurons, Behavior, Data analysis, and Theory, 2024, ISSN 2690-2664
Publisher: NBDT
DOI: 10.51628/001c.123366

1024-channel electrophysiological recordings in macaque V1 and V4 during resting state

Author(s): Chen X*, Morales-Gregorio A*, Sridhar S, Sprenger J, van Albada SJ, Grün S, Roelfsema PR.
Published in: Scientific Data, Issue continuous, 2022, ISSN 2052-4463
Publisher: Springer Nature
DOI: 10.1038/s41597-022-01180-1

Pronouns reactivate conceptual representations in human hippocampal neurons

Author(s): D. E. Dijksterhuis, M. W. Self, J. K. Possel, J. C. Peters, E. C. W. van Straaten, S. Idema, J. C. Baaijen, S. M. A. van der Salm, E. J. Aarnoutse, N. C. E. van Klink, P. van Eijsden, S. Hanslmayr, R. Chelvarajah, F. Roux, L. D. Kolibius, V. Sawlani, D. T. Rollings, S. Dehaene, P. R. Roelfsema
Published in: Science, Issue 385, 2024, Page(s) 1478-1484, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.adr2813

Toward a personalized closed-loop stimulation of the visual cortex: Advances and challenges

Author(s): Grani, F., Soto-Sánchez, C., Fimia, A., & Fernández, E.
Published in: Frontiers in Cellular Neuroscience, Issue Continuous, 2022, ISSN 1662-5102
Publisher: Frontiers Research Foundation
DOI: 10.3389/fncel.2022.1034270

Point-SPV: end-to-end enhancement of object recognition in simulated prosthetic vision using synthetic viewing points

Author(s): Ashkan Nejad, Burcu Küçükoǧlu, Jaap de Ruyter van Steveninck, Sandra Bedrossian, Joost Heutink, Gera A. de Haan, Frans W. Cornelissen, Marcel van Gerven
Published in: Frontiers in Human Neuroscience, Issue 19, 2025, ISSN 1662-5161
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnhum.2025.1549698

Advances and challenges in the development of visual prostheses

Author(s): Eduardo Fernandez, Jose Antonio Robles
Published in: PLOS Biology, Issue 22, 2024, Page(s) e3002896, ISSN 1545-7885
Publisher: PLOS
DOI: 10.1371/journal.pbio.3002896

Impact of transcranial Direct Current Stimulation on stereoscopic vision and retinal structure in adult amblyopic rodents

Author(s): Gema Martinez-Navarrete, Sergio Castaño-Castaño, Miguel Morales-Navas, Francisco Nieto-Escámez, Fernando Sánchez-Santed, Eduardo Fernandez
Published in: Eye and Brain, Issue Volume 16, 2024, Page(s) 75-88, ISSN 1179-2744
Publisher: Taylor and Francis
DOI: 10.2147/eb.s474573

V1 neurons are tuned to perceptual borders in natural scenes

Author(s): Paolo Papale, Wietske Zuiderbaan, Rob R. M. Teeuwen, Amparo Gilhuis, Matthew W. Self, Pieter R. Roelfsema, Serge O. Dumoulin
Published in: Proceedings of the National Academy of Sciences, Issue 121, 2024, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2221623121

Comparison of electrical microstimulation artifact removal methods for high-channel-count prostheses

Author(s): Feng Wang, Xing Chen, Pieter R. Roelfsema
Published in: Journal of Neuroscience Methods, Issue 408, 2024, Page(s) 110169, ISSN 0165-0270
Publisher: Elsevier BV
DOI: 10.1016/j.jneumeth.2024.110169

An extensive dataset of spiking activity to reveal the syntax of the ventral stream

Author(s): Paolo Papale, Feng Wang, Matthew W. Self, Pieter R. Roelfsema
Published in: Neuron, Issue 113, 2025, Page(s) 539-553.e5, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2024.12.003

Multilayer Arrays for Neurotechnology Applications (MANTA): Chronically Stable Thin-Film Intracortical Implants

Author(s): C. Boehler, M. Vomero, M. Soula, M. Vöröslakos, M. Porto Cruz, R. Liljemalm, G. Buzsaki, T. Stieglitz, M. Asplund
Published in: Advanced Science, Issue Monthly, 2023, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/advs.202207576

Time stability and connectivity analysis with an intracortical 96-channel microelectrode array inserted in human visual cortex

Author(s): Grani, F., Soto-Sánchez, C., Farfan, F. D., Alfaro, A., Grima, M. D., Doblado, A. R., & Fernández, E
Published in: Journal of Neural Engineering, Issue Quarterly, 2022, ISSN 1741-2560
Publisher: Institute of Physics Publishing
DOI: 10.1088/1741-2552/ac801d

An integrative, multiscale view on neural theories of consciousness

Author(s): Johan F. Storm, P. Christiaan Klink, Jaan Aru, Walter Senn, Rainer Goebel, Andrea Pigorini, Pietro Avanzini, Wim Vanduffel, Pieter R. Roelfsema, Marcello Massimini, Matthew E. Larkum, Cyriel M.A. Pennartz
Published in: Neuron, Issue 112, 2024, Page(s) 1531-1552, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2024.02.004

Neuronal Waveform Classification in Multielectrode Recordings Using Machine Learning Techniques and Multidimensional Analysis

Author(s): Rocio Lopez-Peco, Mikel Val-Calvo, Cristina Soto-Sanchez, Adrian Villamarin-Ortiz, Gloria Ruiz-Boix, Jose Manuel Ferrandez-Vicente, Eduardo Fernandez
Published in: International Journal of Neural Systems, 2025, ISSN 0129-0657
Publisher: World Scientific Publishing Co
DOI: 10.1142/s0129065725500315

Flexible Polymer Electrodes for Stable Prosthetic Visual Perception in Mice

Author(s): Corinne Orlemann, Christian Boehler, Roxana N. Kooijmans, Bingshuo Li, Maria Asplund, Pieter R. Roelfsema
Published in: Advanced Healthcare Materials, Issue 13, 2024, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202304169

Recording Quality Is Systematically Related to Electrode Impedance

Author(s): Christopher M. Lewis, Christian Boehler, Rickard Liljemalm, Pascal Fries, Thomas Stieglitz, Maria Asplund
Published in: Advanced Healthcare Materials, Issue Continuous, 2024, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202303401

Chronic stability of a neuroprosthesis comprising multiple adjacent Utah arrays in monkeys

Author(s): X. Chen, F: Wang, R. Kooijmans, P.C. Klink, C. Boehler, M. Asplund, P.R. Roelfsema
Published in: Journal of Neural Engineering, Issue Quarterly, 2023, ISSN 1741-2560
Publisher: Institute of Physics Publishing
DOI: 10.1088/1741-2552/ace07e

Visual percepts evoked with an intracortical 96-channel microelectrode array inserted in human occipital cortex

Author(s): Fernandez, E., Alfaro, A., Soto-Sanchez, C., Gonzalez-Lopez, P., Lozano, A., Peña, S., Rodil, A., Gomez, B., Chez, X., Roefsema, P., Rolston, J., Davis, T., Normann, RA.
Published in: Journal of Clinical Investigation, Issue continuous, 2021, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci151331

Electrochemical impedance spectroscopy in vivo for neurotechnology and bioelectronics

Author(s): Hazelgrove, B., Matter, L., Raos, B., Harland, B., Cheng, L., Asplund, M., Svirskis, D.
Published in: Nature Reviews Electrical Engineering, Issue Continuous, 2025, Page(s) 110–124, ISSN 2948-1201
Publisher: Nature
DOI: 10.1038/s44287-024-00126-6

Engineering strategies towards overcoming bleeding and glial scar formation around neural probes

Author(s): Otte E, Vlachos A, Asplund M
Published in: Cell and Tissue Research, Issue 4, 2022, ISSN 0302-766X
Publisher: Springer Verlag
DOI: 10.1007/s00441-021-03567-9

Other (3)

End-to-end Learning of Safe Stimulation Parameters for Cortical Neuroprosthetic Vision

Author(s): Burcu Küçükoğlu, Bodo Rueckauer, Jaap de Ruyter van Steveninck, Maureen van der Grinten, Yağmur Güçlütürk, Pieter R. Roelfsema, Umut Güçlü, Marcel van Gerven
Published in: BioArxiv, Issue Continuously, 2025
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.01.23.634543

Bayesian optimization of cortical neuroprosthetic vision using perceptual feedback

Author(s): Burcu Kucukoglu, Leili Soo, David Leeftink, Fabrizio Grani, Cristina Soto Sanchez, Umut Guclu, Marcel van Gerven, Eduardo Fernandez
Published in: 2025
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.01.24.634528

Decorrelated Soft Actor-Critic for Efficient Deep Reinforcement Learning

Author(s): Burcu Küçükoğlu, Sander Dalm, Marcel van Gerven
Published in: Arxiv, Issue Continuous, 2025
Publisher: Cornell University
DOI: 10.48550/arxiv.2501.19133

Conference proceedings (9)

A 128-channel real-time VPDNN stimulation system for a visual cortical neuroprosthesis

Author(s): Hasan Mohamed, Bogdan Raducanu, Ilya Kiselev, Zuowen Wang, Burcu Küçükoğlu, Bodo Rueckauer, Marcel van Gerven, Carolina Mora Lopez, Shih-Chii Liu
Published in: 2023 IEEE Biomedical Circuits and Systems Conference (BioCAS), 2024, Page(s) 1-5
Publisher: IEEE
DOI: 10.1109/biocas58349.2023.10389055

New Wafer-Level Fabrication of Ultrathin Silicon Insertion Shuttles for Flexible Neural Implants

Author(s): K. Sharma, C. Boehler, M. Asplund, O. Paul, and P. Ruther
Published in: 2023 IEEE 36th International Conference on Micro Electro Mechanical Systems (MEMS), Issue Annually, 2023
Publisher: IEEE
DOI: 10.1109/mems49605.2023.10052581

Experiencing prosthetic vision with event-based sensors

Author(s): Rückauer, B.J.; Gerven, M.A.J. van; Potok, T.E.; Schuman, C.
Published in: Proceedings of the International Conference on Neuromorphic Systems, Issue Annually, 2022
Publisher: Association for Computing Machinery (ACM)
DOI: 10.1145/3546790.3546813

Leveraging Recurrent Neural Networks for Predicting Motor Movements from Primate Motor Cortex Neural Recordings

Author(s): Yuanxi Wang, Zuowen Wang, Shih-Chii Liu
Published in: 2024 IEEE Biomedical Circuits and Systems Conference (BioCAS), 2024, Page(s) 1-5
Publisher: IEEE
DOI: 10.1109/biocas61083.2024.10798182

Lightweight semantic segmentation networks for real-time visual prosthesis applications

Author(s): H. Wang, H. Mohamed, Z. Wang, B. Rueckauer, S-C. Liu
Published in: 2021 ICCV Workshop (The 1st Workshop on Video Scene Parsing in the Wild), Issue 1, 2021, ISSN 2473-9944
Publisher: IEEE Computer Society
DOI: 10.1109/iccvw54120.2021.00300

A 128-channel neural stimulation and recording ASIC for scalable cortical visual prosthesis

Author(s): Bogdan C. Raducanu, Joan Aymerich, Wen-Yang Hsu, Patrick Hendrickx, Carolina Mora Lopez
Published in: ESSCIRC 2023- IEEE 49th European Solid State Circuits Conference (ESSCIRC), 2023, Page(s) 301-304
Publisher: IEEE
DOI: 10.1109/esscirc59616.2023.10268749

Bio-inspired parameter reuse: Exploiting inter-frame representation similarity with recurrence for accelerating temporal visual processing

Author(s): Wang, Zuowen; Cheng, Longbiao; Ott, Joachim; Moure, Pehuen; Liu, Shih-Chii
Published in: Proceedings of Machine Learning Research, Issue 3, 2024, Page(s) 209-222
Publisher: JMLR
DOI: 10.5167/uzh-254310

Fast temporal decoding from large-scale neural recordings in monkey visual cortex

Author(s): Hadorn, J.*, Wang, Z.*, Rueckauer, B., Chen, X., Roelfsema, P., Liu, S.-C
Published in: NeurIPS 2022 Workshop on Shared Visual Representations in Human & Machine Intelligence, Issue Annually, 2022
Publisher: NeurIPS
DOI: 10.3929/ethz-b-000595073

Hierarchical Bonding Yield Test Structure for Flexible High Channel-Count Neural Probes Interfacing ASIC Chips

Author(s): M. C. Odenthal, V. Claar, O. Paul, and P. Ruther
Published in: 2023 IEEE 36th International Conference on Micro Electro Mechanical Systems (MEMS), Issue Annually, 2023
Publisher: IEEE
DOI: 10.1109/mems49605.2023.10052500