Neural Active Visual Prosthetics for Restoring Function

Leistungen

Report & pipeline for self-calibrating stimulation

This report describes the opensource software which will be used for MLbased phosphene vision Opensource software will be disseminated via a publicly accessible repository

Report on flexible shaft electrodes

Report the longterm stability stimulation efficacy and biocompatibility of flexible probes during in vivo applications in the visual cortex of rodents The analysis is based on monitoring tissue gliosis impedance stability and twophoton calcium imaging to access neural activity

Network simulation study

Report of study of the initial AI networks of WP4 targeting the hardware FPGA implementations and the impact of reduced bit precision of weights and activations

Report on self-calibrating neural stimulation

This report describes adaptive algorithms that automatically determine optimal stimulation parameters to induce each phosphene The openaccess report will be submitted to a conference or journal for academic dissemination

Data management plan

Description of the data management plan for the collected data during the project

Project website

Report on project website which will also be used to update the public on the NeuraViPeR project

Complementary metal oxide semiconductor interconnected and stackable (up to 4) multi-shaft 128 channel probes

Flexible probes interconnected with stackable interface, encapsulated and ready for implantation.

Veröffentlichungen

An In-Silico Framework for Modeling Optimal Control of Neural Systems

Autoren: Rueckauer, B. and van Gerven, M.
Veröffentlicht in: Frontiers in Neuroscience, Ausgabe Continuous, 2023, ISSN 1662-4548
Herausgeber: Frontiers Research Foundation
DOI: 10.3389/fnins.2023.1141884

Optimization of Neuroprosthetic Vision via End-to-End Deep Reinforcement Learning

Autoren: Küçükoğlu, B., Rueckauer, B., Ahmad, N., van Steveninck, J. R., Güçlü, U., and van Gerven, M.
Veröffentlicht in: International Journal of Neural Systems, Ausgabe Quarterly, 2022, ISSN 0129-0657
Herausgeber: World Scientific Publishing Co
DOI: 10.1142/s0129065722500526

Solving the binding problem: assemblies form when neurons enhance their firing rate – they don’t need to oscillate or synchronize

Autoren: Roelfsema, P.R
Veröffentlicht in: Neuron, Ausgabe Monthly, 2023, ISSN 0896-6273
Herausgeber: Cell Press
DOI: 10.1016/j.neuron.2023.03.016

1024-channel electrophysiological recordings in macaque V1 and V4 during resting state

Autoren: Chen X*, Morales-Gregorio A*, Sridhar S, Sprenger J, van Albada SJ, Grün S, Roelfsema PR.
Veröffentlicht in: Scientific Data, Ausgabe continuous, 2022, ISSN 2052-4463
Herausgeber: Springer Nature
DOI: 10.1038/s41597-022-01180-1

Toward a personalized closed-loop stimulation of the visual cortex: Advances and challenges

Autoren: Grani, F., Soto-Sánchez, C., Fimia, A., & Fernández, E.
Veröffentlicht in: Frontiers in Cellular Neuroscience, Ausgabe Continuous, 2022, ISSN 1662-5102
Herausgeber: Frontiers Research Foundation
DOI: 10.3389/fncel.2022.1034270

Multilayer Arrays for Neurotechnology Applications (MANTA): Chronically Stable Thin-Film Intracortical Implants

Autoren: C. Boehler, M. Vomero, M. Soula, M. Vöröslakos, M. Porto Cruz, R. Liljemalm, G. Buzsaki, T. Stieglitz, M. Asplund
Veröffentlicht in: Advanced Science, Ausgabe Monthly, 2023, ISSN 2198-3844
Herausgeber: Wiley
DOI: 10.1002/advs.202207576

Time stability and connectivity analysis with an intracortical 96-channel microelectrode array inserted in human visual cortex

Autoren: Grani, F., Soto-Sánchez, C., Farfan, F. D., Alfaro, A., Grima, M. D., Doblado, A. R., & Fernández, E
Veröffentlicht in: Journal of Neural Engineering, Ausgabe Quarterly, 2022, ISSN 1741-2560
Herausgeber: Institute of Physics Publishing
DOI: 10.1088/1741-2552/ac801d

Chronic stability of a neuroprosthesis comprising multiple adjacent Utah arrays in monkeys

Autoren: X. Chen, F: Wang, R. Kooijmans, P.C. Klink, C. Boehler, M. Asplund, P.R. Roelfsema
Veröffentlicht in: Journal of Neural Engineering, Ausgabe Quarterly, 2023, ISSN 1741-2560
Herausgeber: Institute of Physics Publishing
DOI: 10.1088/1741-2552/ace07e

Visual percepts evoked with an intracortical 96-channel microelectrode array inserted in human occipital cortex

Autoren: Fernandez, E., Alfaro, A., Soto-Sanchez, C., Gonzalez-Lopez, P., Lozano, A., Peña, S., Rodil, A., Gomez, B., Chez, X., Roefsema, P., Rolston, J., Davis, T., Normann, RA.
Veröffentlicht in: Journal of Clinical Investigation, Ausgabe continuous, 2021, ISSN 0021-9738
Herausgeber: American Society for Clinical Investigation
DOI: 10.1172/jci151331

Engineering strategies towards overcoming bleeding and glial scar formation around neural probes

Autoren: Otte E, Vlachos A, Asplund M
Veröffentlicht in: Cell and Tissue Research, Ausgabe 4, 2022, ISSN 0302-766X
Herausgeber: Springer Verlag
DOI: 10.1007/s00441-021-03567-9

Biologically plausible phosphene simulation for the differentiable optimization of visual cortical prostheses

Autoren: van der Grinten, M. L., de Ruyter van Steveninck, J., Lozano, A., Pijnacker, L., Rueckauer, B., Roelfsema, P., van Gerven, M., van Wezel, R., Güçlü, U., Güçlütürk, Y.
Veröffentlicht in: bioRxiv, Ausgabe continuous, 2022, ISSN 2692-8205
Herausgeber: Cold Spring Harbor Labs
DOI: 10.1101/2022.12.23.521749

New Wafer-Level Fabrication of Ultrathin Silicon Insertion Shuttles for Flexible Neural Implants

Autoren: K. Sharma, C. Boehler, M. Asplund, O. Paul, and P. Ruther
Veröffentlicht in: 2023 IEEE 36th International Conference on Micro Electro Mechanical Systems (MEMS), Ausgabe Annually, 2023
Herausgeber: IEEE
DOI: 10.1109/mems49605.2023.10052581

Experiencing prosthetic vision with event-based sensors

Autoren: Rückauer, B.J.; Gerven, M.A.J. van; Potok, T.E.; Schuman, C.
Veröffentlicht in: Proceedings of the International Conference on Neuromorphic Systems, Ausgabe Annually, 2022
Herausgeber: Association for Computing Machinery (ACM)
DOI: 10.1145/3546790.3546813

Lightweight semantic segmentation networks for real-time visual prosthesis applications

Autoren: H. Wang, H. Mohamed, Z. Wang, B. Rueckauer, S-C. Liu
Veröffentlicht in: 2021 ICCV Workshop (The 1st Workshop on Video Scene Parsing in the Wild), Ausgabe 1, 2021, ISSN 2473-9944
Herausgeber: IEEE Computer Society
DOI: 10.1109/iccvw54120.2021.00300

Fast temporal decoding from large-scale neural recordings in monkey visual cortex

Autoren: Hadorn, J.*, Wang, Z.*, Rueckauer, B., Chen, X., Roelfsema, P., Liu, S.-C
Veröffentlicht in: NeurIPS 2022 Workshop on Shared Visual Representations in Human & Machine Intelligence, Ausgabe Annually, 2022
Herausgeber: NeurIPS
DOI: 10.3929/ethz-b-000595073

Hierarchical Bonding Yield Test Structure for Flexible High Channel-Count Neural Probes Interfacing ASIC Chips

Autoren: M. C. Odenthal, V. Claar, O. Paul, and P. Ruther
Veröffentlicht in: 2023 IEEE 36th International Conference on Micro Electro Mechanical Systems (MEMS), Ausgabe Annually, 2023
Herausgeber: IEEE
DOI: 10.1109/mems49605.2023.10052500

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