Neural Active Visual Prosthetics for Restoring Function

Resultado final

Report & pipeline for self-calibrating stimulation

This report describes the opensource software which will be used for MLbased phosphene vision Opensource software will be disseminated via a publicly accessible repository

Report on flexible shaft electrodes

Report the longterm stability stimulation efficacy and biocompatibility of flexible probes during in vivo applications in the visual cortex of rodents The analysis is based on monitoring tissue gliosis impedance stability and twophoton calcium imaging to access neural activity

Network simulation study

Report of study of the initial AI networks of WP4 targeting the hardware FPGA implementations and the impact of reduced bit precision of weights and activations

Report on self-calibrating neural stimulation

This report describes adaptive algorithms that automatically determine optimal stimulation parameters to induce each phosphene The openaccess report will be submitted to a conference or journal for academic dissemination

Data management plan

Description of the data management plan for the collected data during the project

Project website

Report on project website which will also be used to update the public on the NeuraViPeR project

Complementary metal oxide semiconductor interconnected and stackable (up to 4) multi-shaft 128 channel probes

Flexible probes interconnected with stackable interface, encapsulated and ready for implantation.

Publicaciones

An In-Silico Framework for Modeling Optimal Control of Neural Systems

Autores: Rueckauer, B. and van Gerven, M.
Publicado en: Frontiers in Neuroscience, Edición Continuous, 2023, ISSN 1662-4548
Editor: Frontiers Research Foundation
DOI: 10.3389/fnins.2023.1141884

Optimization of Neuroprosthetic Vision via End-to-End Deep Reinforcement Learning

Autores: Küçükoğlu, B., Rueckauer, B., Ahmad, N., van Steveninck, J. R., Güçlü, U., and van Gerven, M.
Publicado en: International Journal of Neural Systems, Edición Quarterly, 2022, ISSN 0129-0657
Editor: World Scientific Publishing Co
DOI: 10.1142/s0129065722500526

Solving the binding problem: assemblies form when neurons enhance their firing rate – they don’t need to oscillate or synchronize

Autores: Roelfsema, P.R
Publicado en: Neuron, Edición Monthly, 2023, ISSN 0896-6273
Editor: Cell Press
DOI: 10.1016/j.neuron.2023.03.016

1024-channel electrophysiological recordings in macaque V1 and V4 during resting state

Autores: Chen X*, Morales-Gregorio A*, Sridhar S, Sprenger J, van Albada SJ, Grün S, Roelfsema PR.
Publicado en: Scientific Data, Edición continuous, 2022, ISSN 2052-4463
Editor: Springer Nature
DOI: 10.1038/s41597-022-01180-1

Toward a personalized closed-loop stimulation of the visual cortex: Advances and challenges

Autores: Grani, F., Soto-Sánchez, C., Fimia, A., & Fernández, E.
Publicado en: Frontiers in Cellular Neuroscience, Edición Continuous, 2022, ISSN 1662-5102
Editor: Frontiers Research Foundation
DOI: 10.3389/fncel.2022.1034270

Multilayer Arrays for Neurotechnology Applications (MANTA): Chronically Stable Thin-Film Intracortical Implants

Autores: C. Boehler, M. Vomero, M. Soula, M. Vöröslakos, M. Porto Cruz, R. Liljemalm, G. Buzsaki, T. Stieglitz, M. Asplund
Publicado en: Advanced Science, Edición Monthly, 2023, ISSN 2198-3844
Editor: Wiley
DOI: 10.1002/advs.202207576

Time stability and connectivity analysis with an intracortical 96-channel microelectrode array inserted in human visual cortex

Autores: Grani, F., Soto-Sánchez, C., Farfan, F. D., Alfaro, A., Grima, M. D., Doblado, A. R., & Fernández, E
Publicado en: Journal of Neural Engineering, Edición Quarterly, 2022, ISSN 1741-2560
Editor: Institute of Physics Publishing
DOI: 10.1088/1741-2552/ac801d

Chronic stability of a neuroprosthesis comprising multiple adjacent Utah arrays in monkeys

Autores: X. Chen, F: Wang, R. Kooijmans, P.C. Klink, C. Boehler, M. Asplund, P.R. Roelfsema
Publicado en: Journal of Neural Engineering, Edición Quarterly, 2023, ISSN 1741-2560
Editor: Institute of Physics Publishing
DOI: 10.1088/1741-2552/ace07e

Visual percepts evoked with an intracortical 96-channel microelectrode array inserted in human occipital cortex

Autores: Fernandez, E., Alfaro, A., Soto-Sanchez, C., Gonzalez-Lopez, P., Lozano, A., Peña, S., Rodil, A., Gomez, B., Chez, X., Roefsema, P., Rolston, J., Davis, T., Normann, RA.
Publicado en: Journal of Clinical Investigation, Edición continuous, 2021, ISSN 0021-9738
Editor: American Society for Clinical Investigation
DOI: 10.1172/jci151331

Engineering strategies towards overcoming bleeding and glial scar formation around neural probes

Autores: Otte E, Vlachos A, Asplund M
Publicado en: Cell and Tissue Research, Edición 4, 2022, ISSN 0302-766X
Editor: Springer Verlag
DOI: 10.1007/s00441-021-03567-9

Biologically plausible phosphene simulation for the differentiable optimization of visual cortical prostheses

Autores: van der Grinten, M. L., de Ruyter van Steveninck, J., Lozano, A., Pijnacker, L., Rueckauer, B., Roelfsema, P., van Gerven, M., van Wezel, R., Güçlü, U., Güçlütürk, Y.
Publicado en: bioRxiv, Edición continuous, 2022, ISSN 2692-8205
Editor: Cold Spring Harbor Labs
DOI: 10.1101/2022.12.23.521749

New Wafer-Level Fabrication of Ultrathin Silicon Insertion Shuttles for Flexible Neural Implants

Autores: K. Sharma, C. Boehler, M. Asplund, O. Paul, and P. Ruther
Publicado en: 2023 IEEE 36th International Conference on Micro Electro Mechanical Systems (MEMS), Edición Annually, 2023
Editor: IEEE
DOI: 10.1109/mems49605.2023.10052581

Experiencing prosthetic vision with event-based sensors

Autores: Rückauer, B.J.; Gerven, M.A.J. van; Potok, T.E.; Schuman, C.
Publicado en: Proceedings of the International Conference on Neuromorphic Systems, Edición Annually, 2022
Editor: Association for Computing Machinery (ACM)
DOI: 10.1145/3546790.3546813

Lightweight semantic segmentation networks for real-time visual prosthesis applications

Autores: H. Wang, H. Mohamed, Z. Wang, B. Rueckauer, S-C. Liu
Publicado en: 2021 ICCV Workshop (The 1st Workshop on Video Scene Parsing in the Wild), Edición 1, 2021, ISSN 2473-9944
Editor: IEEE Computer Society
DOI: 10.1109/iccvw54120.2021.00300

Fast temporal decoding from large-scale neural recordings in monkey visual cortex

Autores: Hadorn, J.*, Wang, Z.*, Rueckauer, B., Chen, X., Roelfsema, P., Liu, S.-C
Publicado en: NeurIPS 2022 Workshop on Shared Visual Representations in Human & Machine Intelligence, Edición Annually, 2022
Editor: NeurIPS
DOI: 10.3929/ethz-b-000595073

Hierarchical Bonding Yield Test Structure for Flexible High Channel-Count Neural Probes Interfacing ASIC Chips

Autores: M. C. Odenthal, V. Claar, O. Paul, and P. Ruther
Publicado en: 2023 IEEE 36th International Conference on Micro Electro Mechanical Systems (MEMS), Edición Annually, 2023
Editor: IEEE
DOI: 10.1109/mems49605.2023.10052500

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