Project description
An RNA-based treatment for heart failure
Heart failure is associated with cardiac fibrosis or scarring, an unavoidable consequence of myocardial insult that affects diastolic and systolic function. Despite its great socioeconomic burden, there are no treatments to restore cardiac fibrosis and cure heart failure. The EU-funded MEGFIB project proposes to develop a new approach for treating selected heart failure patients, based on non-coding RNAs, which are emerging as important players in disease pathogenesis. Using oligonucleotides that target the meg3 long non-coding RNA in human cells and tissues, scientists hope to replicate their results in animal models and establish a new approach in heart failure care.
Fields of science
Programme(s)
Funding Scheme
ERC-POC-LS - ERC Proof of Concept Lump Sum PilotHost institution
MEDIZINISCHE HOCHSCHULE HANNOVER
Net EU contribution
€ 150 000,00
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
No data
Region
Niedersachsen Hannover Region Hannover
Beneficiaries (1)
MEDIZINISCHE HOCHSCHULE HANNOVER
Germany
Net EU contribution
€ 150 000,00
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
No data
Region
Niedersachsen Hannover Region Hannover