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Immunological incompatibility as a basis for cancer curing and vaccination

Project description

Immunology-based strategy to target cancer cells for rejection by the organism

The EU-funded ULISES project aims to develop an immunology-based treatment strategy for reprogramming cancer cells to become targetable by a patient’s immune system, emulating the rejection of allogeneic transplants. Moreover, the reprogramming will lead to immunological memory, creating a vaccine-like effect through tumour-infiltrating lymphocytes generated around the tumour microenvironment. The strategy will use porous nanoparticles as carriers to deliver a plasmid DNA cargo into the tumour cells to produce the reprogramming. The researchers will test the implementation and validation of the strategy, focusing on pancreatic cancer as highly aggressive and lacking effective treatments with little life expectancy. However, the developed technology would also be valid for other cancer types.

Call for proposal

H2020-FETOPEN-2018-2020

See other projects for this call

Sub call

H2020-FETOPEN-2018-2019-2020-01

Coordinator

CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
Net EU contribution
€ 454 561,00
Address
Calle Rossello 149 Puerta Bjs
08036 Barcelona
Spain
Activity type
Other
Non-EU contribution
€ 0,00

Participants (12)

Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

HOSPITAL CLINIC DE BARCELONA
Spain
Net EU contribution
€ 0,00
Address
Calle Villarroel 170
08036 Barcelona
Activity type
Research Organisations
Non-EU contribution
€ 0,00
VICTOR PALLARUELO-SANTAMARIA
Spain
Net EU contribution
€ 35 001,50
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
Net EU contribution
€ 244 167,50
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
Net EU contribution
€ 311 667,50
Address
Heidelberglaan 100
3584 CX Utrecht
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
FUNDACION PARA LA FORMACION E INVESTIGACION SANITARIAS DE LA REGION DE MURCIA
Spain
Net EU contribution
€ 239 376,25
Address
Calle Campo 12 Pabellon Docente Del Hospital Clinico Universitario Virgen De La Arrixaca 3 Planta El Palma
30120 Murcia
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

SERVICIO MURCIANO DE SALUD
Spain
Net EU contribution
€ 0,00
Address
C Central 7
30100 Murcia
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

UNIVERSIDAD DE MURCIA
Spain
Net EU contribution
€ 0,00
Address
Avenida Teniente Flomesta S/n - Edificio Convalecencia
30003 Murcia
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Fundación Instituto Valenciano de Oncología
Spain
Net EU contribution
€ 389 792,50
Address
Beltrán Báguena 8
46009 Valencia
Activity type
Research Organisations
Non-EU contribution
€ 0,00
DELPHI GENETICS
Belgium
Net EU contribution
€ 648 542,50
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
Rue Antoine De Saint Exupery 5
6041 Charleroi
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Region
Région wallonne Prov. Hainaut Arr. Charleroi
 
PIRCHE AG
Germany
Net EU contribution
€ 149 583,75
Address
Stuttgarter Platz 2
10627 Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
UNIVERSITAT POLITECNICA DE VALENCIA
Spain
Net EU contribution
€ 334 550,00
Address
Camino De Vera Sn Edificio 3A
46022 Valencia
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
FONDAZIONE ICONS
Italy
Net EU contribution
€ 169 917,50
Address
Piazza Della Vittoria 1
26900 Lodi
Activity type
Other
Non-EU contribution
€ 0,00
Region
Nord-Ovest Lombardia Lodi