Project description
Immunology-based strategy to target cancer cells for rejection by the organism
The EU-funded ULISES project aims to develop an immunology-based treatment strategy for reprogramming cancer cells to become targetable by a patient’s immune system, emulating the rejection of allogeneic transplants. Moreover, the reprogramming will lead to immunological memory, creating a vaccine-like effect through tumour-infiltrating lymphocytes generated around the tumour microenvironment. The strategy will use porous nanoparticles as carriers to deliver a plasmid DNA cargo into the tumour cells to produce the reprogramming. The researchers will test the implementation and validation of the strategy, focusing on pancreatic cancer as highly aggressive and lacking effective treatments with little life expectancy. However, the developed technology would also be valid for other cancer types.
Fields of science
Programme(s)
Funding Scheme
RIA - Research and Innovation actionCoordinator
08036 Barcelona
Spain
Participants (12)
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
30120 Murcia
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
30003 Murcia
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.