Descrizione del progetto
Nuovi farmaci arrestano la replicazione dell’influenza
Gli Influenzavirus sono i responsabili dell’influenza stagionale, che colpisce ogni anno milioni di persone in tutto il mondo. Considerato il potenziale dell’influenza di provocare pandemie con effetti devastanti sulla vita umana e sull’economia, si avverte una pressante esigenza di farmaci antivirali efficaci con un rischio ridotto di provocare evasione virale. Gli scienziati del progetto FluAttack, finanziato dall’UE, hanno identificato una nuova famiglia di molecole come potenti inibitori dei virus dell’influenza. Queste molecole agiscono su una funzione cellulare fondamentale per la sopravvivenza del virus e saranno sottoposte a ulteriori test e caratterizzazione in modelli di infezione influenzale. Il progetto mira a supportare lo sviluppo futuro e la convalida preclinica di questi farmaci antinfluenzali.
Obiettivo
With 3 to 5 million severe cases and up to 650,000 deaths per year worldwide, influenza viruses are not only major human pathogens, they are also a heavy economic burden to our societies. In addition, influenza pandemics can occur at any time with potential devastating effects in terms of lives and costs. Solutions to prevent infection, to treat severe influenza cases and to respond to a severe pandemic are currently extremely limited and rely on vaccination and on only few approved molecules. All these solutions have their limitations with respect to efficacy and all face the problem of viral resistance. Thus, the demand for new options against influenza infections is high. The World Health Organization (WHO) and influenza virus specialists agree that innovative and effective anti-influenza compounds with a reduced risk of viral escape are urgently needed. The main goal of this ERC PoC is to provide key data on a promising innovative therapeutic solution identified in the lab. Taking advantage of a powerful screening system we have developed during the ERC StG ANTIViR, we have identified a family of molecules as potent inhibitors of influenza virus (with IC50<100nM). The mode of action of these molecules is known and they actually target a cellular function essential to all influenza viruses. Preventing viral replication by targeting a cellular function is a novel approach, predicted to strongly reduce the risk of drug resistance. Importantly, one of our hits went through several phase II and III clinical trials as an anti-cancer agent, making this molecule a perfect candidate for drug repurposing. In this context, the specific objectives of this ERC PoC are: i) to further characterise and validate our best hit, in particular in commercial 3D human airway epithelial cells and in vivo in a mouse model, and ii) to secure IPR and to establish an exploitation strategy plan (patent licensing or creation of a start-up) to support future development and preclinical tests.
Campo scientifico
- medical and health sciencesbasic medicinepharmacology and pharmacydrug discovery
- natural sciencesbiological sciencesmicrobiologyvirology
- medical and health scienceshealth sciencespublic healthepidemiologypandemics
- medical and health scienceshealth sciencesinfectious diseasesRNA virusesinfluenza
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantivirals
Parole chiave
Programma(i)
Argomento(i)
Meccanismo di finanziamento
ERC-POC - Proof of Concept GrantIstituzione ospitante
75654 Paris
Francia