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BANKED HEPATOCYTE MONOLAYERS FOR ACCELERATING DRUG TOXICITY SCREENING

Project description

Cryopreservation of hepatocyte monolayers for drug toxicity screening

The goal of the EU-funded FAST_TOX project is to change how liver cells are cryopreserved for the toxicological testing market. Current standard procedures use isolated hepatocyte (liver cells) in toxicity screening. However, these cells must be stored frozen in suspension, while testing is undertaken on cells grown and attached to scaffolds as monolayers. Current methods do not allow cryopreservation of cells as monolayers, and the additional effort involved in processing, plating and growing the cells creates a bottleneck. FAST_TOX will use innovative cryoprotective polymers which allow cryopreservation of hepatocytes directly on the tissue culture plastic, enabling cell banking in an assay-ready format. Researchers have already obtained strong preliminary data demonstrating this concept in several cell lines, filed patents and shown that the polymer materials can be scaled up.

Host institution

THE UNIVERSITY OF WARWICK
Net EU contribution
€ 150 000,00
Address
Kirby Corner Road - University House
CV4 8UW Coventry
United Kingdom

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Region
West Midlands (England) West Midlands Coventry
Activity type
Higher or Secondary Education Establishments
Other funding
No data

Beneficiaries (1)

THE UNIVERSITY OF WARWICK
United Kingdom
Net EU contribution
€ 150 000,00
Address
Kirby Corner Road - University House
CV4 8UW Coventry

See on map

Region
West Midlands (England) West Midlands Coventry
Activity type
Higher or Secondary Education Establishments
Other funding
No data