Pathogen-responsive hydrogels release antimicrobial vesicles for local infection treatment

Projektinformationen

Gels4Bac

ID Finanzhilfevereinbarung: 945602

DOI

10.3030/945602

EK-Unterschriftsdatum 3 November 2020

Startdatum 1 September 2021

Enddatum 31 August 2027

Finanziert unter

• EXCELLENT SCIENCE - European Research Council (ERC)

Gesamtkosten

€ 1 499 333,00

EU-Beitrag

€ 1 499 333,00

Koordiniert durch

FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG
Germany

Periodic Reporting for period 2 - Gels4Bac (Pathogen-responsive hydrogels release antimicrobial vesicles for local infection treatment)

Berichtszeitraum: 2023-03-01 bis 2024-08-31

Zusammenfassung vom Kontext und den Gesamtzielen des Projekts

Bacterial infections are a major global healthcare thread. In Europe alone, up to 33,000 people die each year from infections with resistant bacteria and these numbers are projected to increase in the upcoming years. To prevent a post antibiotic era – during which simple infections may become life threatening – we need to develop new treatment options. Gels4Bac aims to create new options for efficiently treating infectious dispositions by developing bacteria-derived entities as an on-demand customisable, quick and cost-effective treatment avenue.

Arbeit, die ab Beginn des Projekts bis zum Ende des durch den Bericht erfassten Berichtszeitraums geleistet wurde, und die wichtigsten bis dahin erzielten Ergebnisse

During the first 30 months of this project, we focussed on setting up the appropriate culture conditions for bacteria to test the antimicrobial activity of our therapeutic systems. In addition, we set up simple in vitro models to study their toxicity towards human cells, which is important during developing new treatment options. Starting from project year 3 (Jan 2024), we have implemented additional experiments on hydrogel preparation, which are envisioned to become the application form of our antimicrobial therapy.

Fortschritte, die über den aktuellen Stand der Technik hinausgehen und voraussichtliche potenzielle Auswirkungen (einschließlich der bis dato erzielten sozioökonomischen Auswirkungen und weiter gefassten gesellschaftlichen Auswirkungen des Projekts)

Until the end of Gels4Bac, we hope to provide proof-of-concept results on the antimicrobial activity of our new therapeutic systems. We hope to show better antibiotic activity in both cell culture and appropriate in vivo models. We believe our platform technology is imperative to equip Europe in its fight against the rise of infections with resistant bacteria, and will boost Europe's scientific competitiveness in infection therapy.

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