Projektbeschreibung
Wie schlechte Angewohnheiten zu besiegen sind
Drogensucht, unkontrolliertes Geldausgeben, Fressattacken, zwanghafte Rituale – Zwangsverhalten dieser Art ist Teil des Gewohnheitssystems unseres Gehirns. Andererseits sind Gewohnheiten wichtig für unser Leben. Es ist jedoch wenig darüber bekannt, ob wir robustere und festere Gewohnheiten bilden und neuartige Methoden entwickeln können, um die am festesten verankerten Gewohnheiten aufzubrechen. Das EU-finanzierte Projekt HABIT wird die bekannten Unterschiede in der zeitlichen Dynamik der einzelnen Gewohnheitssysteme ausnutzen, bei denen die Reiz-Reaktions-Automatik schnell ist und das zielgerichtete Verhalten langsam erfolgt. Es wird über Smartphones den millisekundengenauen Ablauf der Elektrophysiologie mit der Breite einer umfassenden Phänotypisierung koppeln, um ein neues mechanistisches Modell der unabhängigen Funktion dieser Systeme und ihrer Interaktion zu entwickeln.
Ziel
Every minute of every day, our brain’s habit system is hard at work automating well-practiced actions so our brains can focus on new and more complex challenges. This does not always work to our benefit, however. My research has implicated hyper-expression of habits in a range of compulsive behaviours, from drug addiction to out-of-control spending, binge-eating and obsessive-compulsive rituals. Despite the importance of habits in our lives, there are major gaps in our understanding of how they are acquired in humans and a virtual absence of research into how they can be broken. This is because the mainstay experimental paradigms in the field measure habit expression in a way that cannot distinguish impairments in goal-directed control from the strength of automatic stimulus-response associations. This has led to confounded interpretations that have seriously impeded research aiming to investigate these basic mechanisms. HABIT aims to change this by leveraging known differences in the temporal dynamics of each sysem, where stimulus-response automaticity is fast and goal-directed behaviour, slow. Our novel approach couples the millisecond precision of electrophysiology with the breadth of large-scale phenotyping via smartphone to develop a new mechanistic model of the independent functioning of these systems and their interaction. This novel combination will be used to develop a detailed neural account of both systems and their split-second trade-off, but also to test the real-world functional consequences of disruptions to either system. A series of causal manipulations anchor this grant and are designed to challenge key assumptions of our working model. Can we engineer more robust and rigid habits by-design and develop novel methods to break the most rigid of habits? With clear potential for impact, the fundamental insights from this project will reveal how we can harness the power of habits in our lives and better understand key aspects of mental illness.
Wissenschaftliches Gebiet
Schlüsselbegriffe
Programm/Programme
Thema/Themen
Finanzierungsplan
ERC-STG - Starting GrantGastgebende Einrichtung
D02 CX56 DUBLIN 2
Irland