Thrombotic MEMOry-Linking a break in tolerance to platelets to REthrombosis

Información del proyecto

T-MEMORE

Identificador del acuerdo de subvención: 947611

DOI

10.3030/947611

Proyecto cerrado

Fecha de la firma de la CE 27 Noviembre 2020

Fecha de inicio 1 Diciembre 2020

Fecha de finalización 30 Noviembre 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 483 145,00

Aportación de la UE

€ 1 483 145,00

Coordinado por

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (15)

Interplay between inflammation and thrombosis in cardiovascular pathology

Autores: Konstantin Stark, Steffen Massberg
Publicado en: Nature reviews Cardiology, 2021, ISSN 1759-5002
Editor: Nature Publishing Group
DOI: 10.1038/s41569-021-00552-1

Thromboinflammation in long COVID—the elusive key to postinfection sequelae?

Autores: Leo Nicolai, Rainer Kaiser, Konstantin Stark
Publicado en: Journal of Thrombosis and Haemostasis, 2023, ISSN 1538-7836
Editor: John Wiley
DOI: 10.1016/j.jtha.2023.04.039

Antibodies and complement are key drivers of thrombosis

Autores: Konstantin Stark, Badr Kilani, Sven Stockhausen, Johanna Busse, Irene Schubert, Thuy-Duong Tran, Florian Gaertner, Alexander Leunig, Kami Pekayvaz, Leo Nicolai, Valeria Fumagalli, Julia Stermann, Felix Stephan, Christian David, Martin B. Müller, Birgitta Heyman, Anja Lux, Alexandra da Palma Guerreiro, Lukas P. Frenzel, Christoph Q. Schmidt, Arthur Dopler, Markus Moser, Sue Chandraratne, Marie-Lui
Publicado en: Immunity, Edición 57, 2026, Página(s) 2140-2156.e10, ISSN 1074-7613
Editor: Cell Press
DOI: 10.1016/j.immuni.2024.08.007

Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammation

Autores: Pekayvaz K, Gold C, Hoseinpour P, Engel A, Martinez-Navarro A, Eivers L, Coletti R, Joppich M, Dionísio F, Kaiser R, Tomas L, Janjic A, Knott M, Mehari F, Polewka V, Kirschner M, Boda A, Nicolai L, Schulz H, Titova A, Kilani B, Lorenz M, Fingerle-Rowson G, Bucala R, Enard W, Zimmer R, Weber C, Libby P, Schulz C, Massberg S, Stark K.
Publicado en: Immunity, 2023, ISSN 1097-4180
Editor: Cell Press
DOI: 10.1016/j.immuni.2023.08.002

Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection

Autores: Kami Pekayvaz, Alexander Leunig, Rainer Kaiser, Markus Joppich, Sophia Brambs, Aleksandar Janjic, Oliver Popp, Daniel Nixdorf, Valeria Fumagalli, Nora Schmidt, Vivien Polewka, Afra Anjum, Viktoria Knottenberg, Luke Eivers, Lucas E. Wange, Christoph Gold, Marieluise Kirchner, Maximilian Muenchhoff, Johannes C. Hellmuth, Clemens Scherer, Raquel Rubio-Acero, Tabea Eser, Flora Deák, Kerstin Puchinger
Publicado en: Nature Communications, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-28508-0

Self-sustaining IL-8 loops drive a prothrombotic neutrophil phenotype in severe COVID-19

Autores: Rainer Kaiser,1,2,3 Alexander Leunig,corresponding author1,2 Kami Pekayvaz,1,2,3 Oliver Popp,4,5 Markus Joppich,6 Vivien Polewka,1 Raphael Escaig,1 Afra Anjum,1 Marie-Louise Hoffknecht,1 Christoph Gold,1 Sophia Brambs,1 Anouk Engel,1 Sven Stockhausen,1,2 Viktoria Knottenberg,1 Anna Titova,1 Mohamed Haji,4,5 Clemens Scherer,1,2,3 Maximilian Muenchhoff,3,7,8 Johannes C. Hellmuth,3,9 Kathrin Saar,4,5
Publicado en: Blood, 2021, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1172/jci.insight.150862

Neutrophil-Driven Trogocytosis in Pancreatic Ductal Adenocarcinoma Liver Metastases Restrains Immunosuppressive Macrophage Polarization and Limits Metastatic Progression

Autores: Larissa Belz, Dominic van den Heuvel, Badr Kilani, Alejandro Martinez-Navarro, Anastassia Akhalkatsi, Markus Joppich, Yinfeng Zhu, Qiongjie Ding, Jinlong Wan, Julia Stermann, Julia Winterhalter, Denise Messerer, Anna Titova, Sanjana Balaji, Santoshi Giri, Luke Eivers, Sebastian Widholz, Stefanie Bärthel, Elisabeth Raatz, Dieter Saur, Kirsten Lauber, Georg Beyer, Julia Mayerle, Steffen Ormanns, Mi
Publicado en: Gastroenterology, 2026, ISSN 0016-5085
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2026.04.021

Thromboinflammation in long COVID-the elusive key to postinfection sequelae?

Autores: Leo Nicolai, Rainer Kaiser, Konstantin Stark
Publicado en: Journal of Thrombosis and Haemostasis, 2023, ISSN 1538-7836
Editor: Elsevier

Differential Effects of Erythropoietin Administration and Overexpression on Venous Thrombosis in Mice

Autores: Sven Stockhausen, Badr Kilani, Irene Schubert, Anna-Lena Steinsiek, Sue Chandraratne, Franziska Wendler, Luke Eivers, Marie-Luise von Brühl, Steffen Massberg, Ilka Ott, Konstantin Stark
Publicado en: Thrombosis and Haemostasis, Edición 124, 2024, Página(s) 1027-1039, ISSN 0340-6245
Editor: Schattauer
DOI: 10.1055/s-0043-1775965

Multiomic analyses uncover immunological signatures in acute and chronic coronary syndromes

Autores: Kami Pekayvaz, Corinna Losert, Viktoria Knottenberg, Christoph Gold, Irene V. van Blokland, Roy Oelen, Hilde E. Groot, Jan Walter Benjamins, Sophia Brambs, Rainer Kaiser, Adrian Gottschlich, Gordon Victor Hoffmann, Luke Eivers, Alejandro Martinez-Navarro, Nils Bruns, Susanne Stiller, Sezer Akgöl, Keyang Yue, Vivien Polewka, Raphael Escaig, Markus Joppich, Aleksandar Janjic, Oliver Popp, Sebastian
Publicado en: Nature Medicine, Edición 30, 2024, Página(s) 1696-1710, ISSN 1078-8956
Editor: Nature Publishing Group
DOI: 10.1038/s41591-024-02953-4

Intravital calcium imaging in myeloid leukocytes identifies calcium frequency spectra as indicators of functional states

Autores: Mehari FT, Miller M, Pick R, Bader A, Pekayvaz K, Napoli M, Uhl B, Reichel CA, Sperandio M, Walzog B, Schulz C, Massberg S, Stark K
Publicado en: Science Signaling, 2022, ISSN 1945-0877
Editor: American Association for the Advancement of Science
DOI: 10.1126/scisignal.abe6909

Procoagulant platelet sentinels prevent inflammatory bleeding through GPIIBIIIA and GPVI

Autores: Rainer Kaiser 1 , Raphael Escaig 1 , Jan Kranich 2 , Marie-Louise Hoffknecht 3 , Afra Anjum 3 , Vivien Polewka 3 , Magdalena Mader 4 , Wenbo Hu 2 , Larissa Belz 3 , Christoph Gold 4 , Anna Titova 4 , Michael Lorenz 5 , Kami Pekayvaz 1 , Stefan Kääb 1 , Florian Gaertner 6 , Konstantin Stark 1 , Thomas Brocker 2 , Steffen Massberg 1 , Leo Nicolai 1
Publicado en: Blood, 2021, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood.2021014914

Thrombocytopenia and splenic platelet directed immune responses after intravenous ChAdOx1 nCov-19 administration.

Autores: "Leo Nicolai,1,2,#§ Alexander Leunig,1,2,#§ Kami Pekayvaz,1,2,#§ Max Esefeld,3 Afra Anjum,1 Justina Rath,3 Eva Riedlinger,1 Vincent Ehreiser,1,2 Magdalena Mader,1 Luke Eivers,1 Marie-Louise Hoffknecht,1 Zhe Zhang,1 Daniela Kugelmann,4 Dario Rossaro,1 Raphael Escaig,1 Rainer Kaiser,1,2 Vivien Polewka,1 Anna Titova,1 Tobias Petzold,1,2 Karsten Spiekermann,5 Matteo Iannacone,6 Thomas Thiele,3 Andre"
Publicado en: Blood, 2022, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood.2021014712

Immunothrombolytic monocyte-neutrophil axes dominate the single-cell landscape of human thrombosis and correlate with thrombus resolution

Autores: Kami Pekayvaz, Badr Kilani, Markus Joppich, Luke Eivers, Sophia Brambs, Viktoria Knottenberg, Sezer Akgöl, Keyang Yue, Lukas Li, Alejandro Martinez-Navarro, Rainer Kaiser, Nina Meißner, Heiko Schulz, Larissa Belz, Anastassia Akhalkatsi, Sven Stockhausen, Tonina T. Mueller, Simon Millonig, Lea Hartelt, Christoph Gold, Aleksandar Janjic, Vivien Polewka, Franziska Wendler, Augustin Droste zu Senden
Publicado en: Immunity, Edición 58, 2025, Página(s) 1343-1358.e13, ISSN 1074-7613
Editor: Cell Press
DOI: 10.1016/j.immuni.2025.03.020

Differential Effects of Erythropoietin Administration and Overexpression on Venous Thrombosis in Mice.

Autores: Stockhausen S, Kilani B, Schubert I, Steinsiek AL, Chandraratne S, Wendler F, Eivers L, von Brühl ML, Massberg S, Ott I, Stark K.
Publicado en: Thrombosis Haemostasis, 2023, ISSN 0340-6245
Editor: Schattauer