Thrombotic MEMOry-Linking a break in tolerance to platelets to REthrombosis

Informazioni relative al progetto

T-MEMORE

ID dell’accordo di sovvenzione: 947611

DOI

10.3030/947611

Progetto chiuso

Data della firma CE 27 Novembre 2020

Data di avvio 1 Dicembre 2020

Data di completamento 30 Novembre 2025

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 483 145,00

Contributo UE

€ 1 483 145,00

Coordinato da

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (15)

Interplay between inflammation and thrombosis in cardiovascular pathology

Autori: Konstantin Stark, Steffen Massberg
Pubblicato in: Nature reviews Cardiology, 2021, ISSN 1759-5002
Editore: Nature Publishing Group
DOI: 10.1038/s41569-021-00552-1

Thromboinflammation in long COVID—the elusive key to postinfection sequelae?

Autori: Leo Nicolai, Rainer Kaiser, Konstantin Stark
Pubblicato in: Journal of Thrombosis and Haemostasis, 2023, ISSN 1538-7836
Editore: John Wiley
DOI: 10.1016/j.jtha.2023.04.039

Antibodies and complement are key drivers of thrombosis

Autori: Konstantin Stark, Badr Kilani, Sven Stockhausen, Johanna Busse, Irene Schubert, Thuy-Duong Tran, Florian Gaertner, Alexander Leunig, Kami Pekayvaz, Leo Nicolai, Valeria Fumagalli, Julia Stermann, Felix Stephan, Christian David, Martin B. Müller, Birgitta Heyman, Anja Lux, Alexandra da Palma Guerreiro, Lukas P. Frenzel, Christoph Q. Schmidt, Arthur Dopler, Markus Moser, Sue Chandraratne, Marie-Lui
Pubblicato in: Immunity, Numero 57, 2026, Pagina/e 2140-2156.e10, ISSN 1074-7613
Editore: Cell Press
DOI: 10.1016/j.immuni.2024.08.007

Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammation

Autori: Pekayvaz K, Gold C, Hoseinpour P, Engel A, Martinez-Navarro A, Eivers L, Coletti R, Joppich M, Dionísio F, Kaiser R, Tomas L, Janjic A, Knott M, Mehari F, Polewka V, Kirschner M, Boda A, Nicolai L, Schulz H, Titova A, Kilani B, Lorenz M, Fingerle-Rowson G, Bucala R, Enard W, Zimmer R, Weber C, Libby P, Schulz C, Massberg S, Stark K.
Pubblicato in: Immunity, 2023, ISSN 1097-4180
Editore: Cell Press
DOI: 10.1016/j.immuni.2023.08.002

Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection

Autori: Kami Pekayvaz, Alexander Leunig, Rainer Kaiser, Markus Joppich, Sophia Brambs, Aleksandar Janjic, Oliver Popp, Daniel Nixdorf, Valeria Fumagalli, Nora Schmidt, Vivien Polewka, Afra Anjum, Viktoria Knottenberg, Luke Eivers, Lucas E. Wange, Christoph Gold, Marieluise Kirchner, Maximilian Muenchhoff, Johannes C. Hellmuth, Clemens Scherer, Raquel Rubio-Acero, Tabea Eser, Flora Deák, Kerstin Puchinger
Pubblicato in: Nature Communications, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-28508-0

Self-sustaining IL-8 loops drive a prothrombotic neutrophil phenotype in severe COVID-19

Autori: Rainer Kaiser,1,2,3 Alexander Leunig,corresponding author1,2 Kami Pekayvaz,1,2,3 Oliver Popp,4,5 Markus Joppich,6 Vivien Polewka,1 Raphael Escaig,1 Afra Anjum,1 Marie-Louise Hoffknecht,1 Christoph Gold,1 Sophia Brambs,1 Anouk Engel,1 Sven Stockhausen,1,2 Viktoria Knottenberg,1 Anna Titova,1 Mohamed Haji,4,5 Clemens Scherer,1,2,3 Maximilian Muenchhoff,3,7,8 Johannes C. Hellmuth,3,9 Kathrin Saar,4,5
Pubblicato in: Blood, 2021, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1172/jci.insight.150862

Neutrophil-Driven Trogocytosis in Pancreatic Ductal Adenocarcinoma Liver Metastases Restrains Immunosuppressive Macrophage Polarization and Limits Metastatic Progression

Autori: Larissa Belz, Dominic van den Heuvel, Badr Kilani, Alejandro Martinez-Navarro, Anastassia Akhalkatsi, Markus Joppich, Yinfeng Zhu, Qiongjie Ding, Jinlong Wan, Julia Stermann, Julia Winterhalter, Denise Messerer, Anna Titova, Sanjana Balaji, Santoshi Giri, Luke Eivers, Sebastian Widholz, Stefanie Bärthel, Elisabeth Raatz, Dieter Saur, Kirsten Lauber, Georg Beyer, Julia Mayerle, Steffen Ormanns, Mi
Pubblicato in: Gastroenterology, 2026, ISSN 0016-5085
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2026.04.021

Thromboinflammation in long COVID-the elusive key to postinfection sequelae?

Autori: Leo Nicolai, Rainer Kaiser, Konstantin Stark
Pubblicato in: Journal of Thrombosis and Haemostasis, 2023, ISSN 1538-7836
Editore: Elsevier

Differential Effects of Erythropoietin Administration and Overexpression on Venous Thrombosis in Mice

Autori: Sven Stockhausen, Badr Kilani, Irene Schubert, Anna-Lena Steinsiek, Sue Chandraratne, Franziska Wendler, Luke Eivers, Marie-Luise von Brühl, Steffen Massberg, Ilka Ott, Konstantin Stark
Pubblicato in: Thrombosis and Haemostasis, Numero 124, 2024, Pagina/e 1027-1039, ISSN 0340-6245
Editore: Schattauer
DOI: 10.1055/s-0043-1775965

Multiomic analyses uncover immunological signatures in acute and chronic coronary syndromes

Autori: Kami Pekayvaz, Corinna Losert, Viktoria Knottenberg, Christoph Gold, Irene V. van Blokland, Roy Oelen, Hilde E. Groot, Jan Walter Benjamins, Sophia Brambs, Rainer Kaiser, Adrian Gottschlich, Gordon Victor Hoffmann, Luke Eivers, Alejandro Martinez-Navarro, Nils Bruns, Susanne Stiller, Sezer Akgöl, Keyang Yue, Vivien Polewka, Raphael Escaig, Markus Joppich, Aleksandar Janjic, Oliver Popp, Sebastian
Pubblicato in: Nature Medicine, Numero 30, 2024, Pagina/e 1696-1710, ISSN 1078-8956
Editore: Nature Publishing Group
DOI: 10.1038/s41591-024-02953-4

Intravital calcium imaging in myeloid leukocytes identifies calcium frequency spectra as indicators of functional states

Autori: Mehari FT, Miller M, Pick R, Bader A, Pekayvaz K, Napoli M, Uhl B, Reichel CA, Sperandio M, Walzog B, Schulz C, Massberg S, Stark K
Pubblicato in: Science Signaling, 2022, ISSN 1945-0877
Editore: American Association for the Advancement of Science
DOI: 10.1126/scisignal.abe6909

Procoagulant platelet sentinels prevent inflammatory bleeding through GPIIBIIIA and GPVI

Autori: Rainer Kaiser 1 , Raphael Escaig 1 , Jan Kranich 2 , Marie-Louise Hoffknecht 3 , Afra Anjum 3 , Vivien Polewka 3 , Magdalena Mader 4 , Wenbo Hu 2 , Larissa Belz 3 , Christoph Gold 4 , Anna Titova 4 , Michael Lorenz 5 , Kami Pekayvaz 1 , Stefan Kääb 1 , Florian Gaertner 6 , Konstantin Stark 1 , Thomas Brocker 2 , Steffen Massberg 1 , Leo Nicolai 1
Pubblicato in: Blood, 2021, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood.2021014914

Thrombocytopenia and splenic platelet directed immune responses after intravenous ChAdOx1 nCov-19 administration.

Autori: "Leo Nicolai,1,2,#§ Alexander Leunig,1,2,#§ Kami Pekayvaz,1,2,#§ Max Esefeld,3 Afra Anjum,1 Justina Rath,3 Eva Riedlinger,1 Vincent Ehreiser,1,2 Magdalena Mader,1 Luke Eivers,1 Marie-Louise Hoffknecht,1 Zhe Zhang,1 Daniela Kugelmann,4 Dario Rossaro,1 Raphael Escaig,1 Rainer Kaiser,1,2 Vivien Polewka,1 Anna Titova,1 Tobias Petzold,1,2 Karsten Spiekermann,5 Matteo Iannacone,6 Thomas Thiele,3 Andre"
Pubblicato in: Blood, 2022, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood.2021014712

Immunothrombolytic monocyte-neutrophil axes dominate the single-cell landscape of human thrombosis and correlate with thrombus resolution

Autori: Kami Pekayvaz, Badr Kilani, Markus Joppich, Luke Eivers, Sophia Brambs, Viktoria Knottenberg, Sezer Akgöl, Keyang Yue, Lukas Li, Alejandro Martinez-Navarro, Rainer Kaiser, Nina Meißner, Heiko Schulz, Larissa Belz, Anastassia Akhalkatsi, Sven Stockhausen, Tonina T. Mueller, Simon Millonig, Lea Hartelt, Christoph Gold, Aleksandar Janjic, Vivien Polewka, Franziska Wendler, Augustin Droste zu Senden
Pubblicato in: Immunity, Numero 58, 2025, Pagina/e 1343-1358.e13, ISSN 1074-7613
Editore: Cell Press
DOI: 10.1016/j.immuni.2025.03.020

Differential Effects of Erythropoietin Administration and Overexpression on Venous Thrombosis in Mice.

Autori: Stockhausen S, Kilani B, Schubert I, Steinsiek AL, Chandraratne S, Wendler F, Eivers L, von Brühl ML, Massberg S, Ott I, Stark K.
Pubblicato in: Thrombosis Haemostasis, 2023, ISSN 0340-6245
Editore: Schattauer