Project description
Targeting non-coding DNA for the development of innovative anticancer therapies
Functional non-coding regions of the genome play a critical role in gene expression regulation. Still, our knowledge of the disease-associated functional elements in the non-coding genome is limited. The EU-funded FIND-seq project proposes a multi-scale, general approach to study the role of non-coding sequences in the context of blood malignancies. The project will investigate non-coding sequences in which activation or repression in chromatin state is associated with drug resistance in chronic myelogenous leukaemia (CML). The research will focus on the alterations in the chromatin structure associated with imatinib resistance in CML. A better understanding of the non-coding regulatory changes in diseases will provide the basis for the development of innovative therapies targeting the non-coding genome.
Fields of science
Programme(s)
Topic(s)
Funding Scheme
ERC-STG - Starting GrantHost institution
1090 Wien
Austria
See on map
Beneficiaries (2)
1090 Wien
See on map
Participation ended
1090 Wien
See on map