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Functional Interrogation of Non-coding DNA Sequences in leukemia development and drug resistance

Project description

Targeting non-coding DNA for the development of innovative anticancer therapies

Functional non-coding regions of the genome play a critical role in gene expression regulation. Still, our knowledge of the disease-associated functional elements in the non-coding genome is limited. The EU-funded FIND-seq project proposes a multi-scale, general approach to study the role of non-coding sequences in the context of blood malignancies. The project will investigate non-coding sequences in which activation or repression in chromatin state is associated with drug resistance in chronic myelogenous leukaemia (CML). The research will focus on the alterations in the chromatin structure associated with imatinib resistance in CML. A better understanding of the non-coding regulatory changes in diseases will provide the basis for the development of innovative therapies targeting the non-coding genome.

Host institution

ST. ANNA KINDERKREBSFORSCHUNG GMBH
Net EU contribution
€ 1 784 000,00
Address
Zimmermannplatz 10
1090 Wien
Austria

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Region
Wien Wien
Activity type
Research Organisations
Non-EU contribution
€ 0,00

Beneficiaries (2)

ST. ANNA KINDERKREBSFORSCHUNG GMBH
Austria
Net EU contribution
€ 1 784 000,00
Address
Zimmermannplatz 10
1090 Wien

See on map

Region
Wien Wien
Activity type
Research Organisations
Non-EU contribution
€ 0,00
ST ANNA KINDERKREBSFORSCHUNG VEREIN

Participation ended

Austria
Net EU contribution
€ 0,00
Non-EU contribution
€ 0,00