Topologically Active Polymers

Información del proyecto

TAP

Identificador del acuerdo de subvención: 947918

DOI

10.3030/947918

Proyecto cerrado

Fecha de la firma de la CE 20 Octubre 2020

Fecha de inicio 1 Enero 2021

Fecha de finalización 31 Diciembre 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 499 950,00

Aportación de la UE

€ 1 499 950,00

Coordinado por

THE UNIVERSITY OF EDINBURGH
United Kingdom

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Open Research Data Pilot (1)

Open Research Data Pilot

Publicaciones

Peer reviewed articles (32)

Single-Molecule Structure and Topology of Kinetoplast DNA Networks

Autores: Pinyao He; Allard J. Katan; Luca Tubiana; Cees Dekker; Davide Michieletto
Publicado en: Physical Review X, Edición 13, 2023, ISSN 2160-3308
Editor: American Physical Society
DOI: 10.1103/physrevx.13.021010

Runaway transition in irreversible polymer condensation with cyclization

Autores: Maria Panoukidou, Simon Weir, Valerio Sorichetti, Yair Gutierrez Fosado, Martin Lenz, Davide Michieletto
Publicado en: Physical Review Research, Edición 6, 2024, ISSN 2643-1564
Editor: American Physical Society (APS)
DOI: 10.1103/physrevresearch.6.023189

Topology in soft and biological matter

Autores: Luca Tubiana, Gareth P. Alexander, Agnese Barbensi, Dorothy Buck, Julyan H.E. Cartwright, Mateusz Chwastyk, Marek Cieplak, Ivan Coluzza, Simon Čopar, David J. Craik, Marco Di Stefano, Ralf Everaers, Patrícia F.N. Faísca, Franco Ferrari, Achille Giacometti, Dimos Goundaroulis, Ellinor Haglund, Ya-Ming Hou, Nevena Ilieva, Sophie E. Jackson, Aleksandre Japaridze, Noam Kaplan, Alexander R. Klotz, H
Publicado en: Physics Reports, Edición 1075, 2024, Página(s) 1-137, ISSN 0370-1573
Editor: Elsevier BV
DOI: 10.1016/j.physrep.2024.04.002

Investigating site-selection mechanisms of retroviral integration in supercoiled DNA braids

Autores: G. Forte, D. Michieletto, D. Marenduzzo, E. Orlandini
Publicado en: Journal of The Royal Society Interface, Edición 18, 2021, Página(s) 20210229, ISSN 1742-5662
Editor: The Royal Society
DOI: 10.1098/rsif.2021.0229

Topological digestion drives time-varying rheology of entangled DNA fluids

Autores: Michieletto D,Neill P, Weir S, Evans D, Crist N, Martinez V, Robertson-Anderson R
Publicado en: Nature Communications, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-31828-w

Geometric learning of knot topology

Autores: Joseph Lahoud Sleiman; Filippo Conforto; Yair Augusto Gutierrez Fosado; Davide Michieletto
Publicado en: Crossref, Edición 5, 2024, ISSN 1744-6848
Editor: RSC
DOI: 10.1039/d3sm01199b

An Inter-strand Loop Extrusion Model

Autores: Andrea Bonato; Davide Michieletto
Publicado en: Biophysical Journal, Edición 1, 2021, ISSN 0006-3495
Editor: Biophysical Society
DOI: 10.48550/arxiv.2111.00332

Fluidification of entanglements by a DNA bending protein

Autores: Yair A. G. Fosado; Jamieson Howard; Simon Weir; Agnes Noy; Mark C. Leake; Davide Michieletto
Publicado en: Physical Review Letters, Edición 130, 2023, ISSN 0031-9007
Editor: American Physical Society
DOI: 10.48550/arxiv.2205.03510

Rheology and Viscoelasticity of Proteins and Nucleic Acids Condensates

Autores: Davide Michieletto; Mattia Marenda
Publicado en: JACS Au, Edición 2, 2022, ISSN 2691-3704
Editor: ACS
DOI: 10.1021/jacsau.2c00055

Topological gelation of reconnecting polymers

Autores: Andrea Bonato; Davide Marenduzzo; Davide Michieletto; Enzo Orlandini
Publicado en: PNAS, Edición 119, 2022, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1101/2022.09.21.508941

ParB proteins can bypass DNA-bound roadblocks via dimer-dimer recruitment

Autores: MILOŠ TIŠMA, MARIA PANOUKIDOU, HAMMAM ANTAR, YOUNG-MIN SOH, ROMAN BARTH, BISWAJIT PRADHAN, ANDERS BARTH, JACO VAN DER TORRE, DAVIDE MICHIELETTO, STEPHAN GRUBER, CEES DEKKER
Publicado en: Science Advances, Edición 8, 2022, ISSN 2375-2548
Editor: AAAS
DOI: 10.1126/sciadv.abn3299

Kinetoplast DNA: a polymer physicist’s topological Olympic dream

Autores: Davide Michieletto
Publicado en: Nucleic Acids Research, Edición 53, 2025, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkae1206

Parameter-free molecular super-structures quantification in single-molecule localization microscopy.

Autores: Mattia Marenda; Elena Lazarova; Sebastian van de Linde; Nick Gilbert; Davide Michieletto
Publicado en: Journal of Cell Biology, Edición 1, 2021, ISSN 0021-9525
Editor: Rockefeller University Press
DOI: 10.1083/jcb.202010003

Spontaneously directed loop extrusion in SMC complexes emerges from broken detailed balance and anisotropic DNA search

Autores: Andrea Bonato, Jae-Won Jang, Do-Gyun Kim, Kyoung-Wook Moon, Davide Michieletto, Je-Kyung Ryu
Publicado en: Nucleic Acids Research, Edición 53, 2025, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkaf725

Effects of monovalent and divalent cations on the rheology of entangled DNA

Autores: Jennifer Harnett, Simon Weir, Davide Michieletto
Publicado en: Soft Matter, Edición 20, 2024, Página(s) 3980-3986, ISSN 1744-683X
Editor: Royal Society of Chemistry
DOI: 10.1039/d3sm00957b

Universal and Programmable Thinning and Thickening of Topologically-Active DNA Fluids

Autores: Davide Michieletto; P. Neill; S. Weir; Vincent A. Martinez; David M. Evans; Crist N; Anderson R
Publicado en: Nature Communications, Edición 13, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.48550/arxiv.2106.08861

Link to Densify: Topological Transitions and Origin of Hysteresis During the Compression and Decompression of Amorphous Ices

Autores: Yair Augusto Gutiérrez Fosado, Davide Michieletto, Fausto Martelli
Publicado en: Physical Review Letters, Edición 133, 2025, ISSN 0031-9007
Editor: American Physical Society
DOI: 10.1103/physrevlett.133.266102

Condensin extrudes DNA loops in steps up to hundreds of base pairs that are generated by ATP binding events

Autores: Je-Kyung Ryu; Sang-Hyun Rah; Richard Janissen; Jacob W. J. Kerssemakers; Andrea Bonato; Davide Michieletto; Cees Dekker
Publicado en: Ryu , J-K , Rah , S-H , Janissen , R , Kerssemakers , J W J , Bonato , A , Michieletto , D & Dekker , C 2022 , ' Condensin extrudes DNA loops in steps up to hundreds of base pairs that are generated by ATP binding events ' , Nucleic Acids Research , vol. 50 , no. 2 , pp. 820-832 . https://doi.org/10.1093/nar/gkab1268, Edición 3, 2022, ISSN 1362-4962
Editor: Oxford University Press
DOI: 10.1101/2020.11.04.368506

Single-Molecule Morphology of Topologically Digested Olympic Networks

Autores: Saminathan Ramakrishnan, Zihao Chen, Yair Augusto Gutierrez Fosado, Luca Tubiana, Willem Vanderlinden, Nicholas Jon Savill, Achim Schnaufer, Davide Michieletto
Publicado en: PRX Life, Edición 2, 2024, ISSN 2835-8279
Editor: American Physical Society (APS)
DOI: 10.1103/prxlife.2.013009

Fluidification of entangled polymers by loop extrusion

Autores: Filippo Conforto, Yair Gutierrez Fosado, Davide Michieletto
Publicado en: Physical Review Research, Edición 6, 2024, ISSN 2643-1564
Editor: American Physical Society (APS)
DOI: 10.1103/physrevresearch.6.033160

Nanostars planarity modulates the elasticity of DNA hydrogels

Autores: Fosado, Yair Augusto Gutierrez
Publicado en: Soft Matter, Edición 6, 2023, ISSN 1744-6848
Editor: RSC
DOI: 10.1039/d2sm00221c

Dynamic and Facilitated Binding of Topoisomerase Accelerates Topological Relaxation

Autores: Davide Michieletto; Yair A G Fosado; Elias Melas; Marco Baiesi; Luca Tubiana; Enzo Orlandini
Publicado en: Nucleic Acids Research, Edición 50, 2022, ISSN 1362-4962
Editor: Oxford University Press
DOI: 10.1093/nar/gkac260

Polycomb condensates can promote epigenetic marks but are not required for sustained chromatin compaction

Autores: Jorine M. Eeftens, Manya Kapoor, Davide Michieletto, Clifford P. Brangwynne
Publicado en: Nature Communications, Edición 12, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-26147-5

Geometric Predictors of Knotted and Linked Arcs

Autores: Joseph L. Sleiman; Robin H. Burton; Michele Caraglio; Yair Augusto Gutierrez Fosado; Davide Michieletto
Publicado en: ACS Polymers Au, Edición 2, 2022, ISSN 2694-2453
Editor: ACS
DOI: 10.1021/acspolymersau.2c00021

Nonequilibrium dynamics and action at a distance in transcriptionally driven DNA supercoiling

Autores: Yair A. G. Fosado, Davide Michieletto, Chris A. Brackley, Davide Marenduzzo
Publicado en: PNAS, Edición 118, 2021, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1905215118

Topological linking determines elasticity in limited valence networks

Autores: Giorgia Palombo, Simon Weir, Davide Michieletto, Yair Augusto Gutiérrez Fosado
Publicado en: Nature Materials, Edición 24, 2025, Página(s) 454-461, ISSN 1476-1122
Editor: Nature Publishing Group
DOI: 10.1038/s41563-024-02091-9

ParB proteins can bypass DNA-bound roadblocks via dimer-dimer recruitment.

Autores: Tišma, Miloš; Panoukidou, Maria; Antar, Hammam; Soh, Young-Min; Barth, Roman; Pradhan, Biswajit; Barth, Anders; van der Torre, Jaco; Michieletto, Davide; Gruber, Stephan; Dekker, Cees
Publicado en: Science advances, vol. 8, no. 26, pp. eabn3299, Edición 12, 2023, ISSN 2375-2548
Editor: AAAS

Simplifying topological entanglements by entropic competition of slip-links

Autores: Andrea Bonato; Davide Marenduzzo; Davide Michieletto
Publicado en: Physical Review Research, Edición 2, 2021, ISSN 2643-1564
Editor: APS
DOI: 10.1103/physrevresearch.3.043070

Topological Tuning of DNA Mobility in Entangled Solutions of Supercoiled Plasmids

Autores: Jan Smrek; Jonathan Garamella; Rae M. Robertson-Anderson; Davide Michieletto
Publicado en: Science Advances, Edición 2, 2021, ISSN 2375-2548
Editor: AAAS
DOI: 10.1101/2020.09.21.306092

Topology-Controlled Microphase Separation and Interconversion of Twist and Writhe Domains in Supercoiled Annealed Polyelectrolytes

Autores: Roman Staňo, Christos N. Likos, Davide Michieletto, Jan Smrek
Publicado en: Physical Review Letters, Edición 135, 2025, ISSN 0031-9007
Editor: American Physical Society
DOI: 10.1103/7fh5-frst

Topologically-crosslinked hydrogels based on γ-cyclodextrins

Autores: Ella Sapsford, Davide Michieletto
Publicado en: Communications Chemistry, Edición 8, 2025, ISSN 2399-3669
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s42004-025-01469-3

Loops are Geometric Catalysts for DNA Integration

Autores: Cleis Battaglia, Davide Michieletto
Publicado en: Nucleic Acids Research, Edición 52, 2026, ISSN 1362-4962
Editor: OUP
DOI: 10.1101/2023.06.21.545982