Molecular and metabolic mechanisms underlying mitochondrial dysfunction

Project description

Cell components contributing to mitochondrial dysfunction

Mitochondrial electron transport chain (ETC) defects underlie biochemical failure and pathologies associated with mitochondrial dysfunction. The EU-funded MitoCure project proposes a comprehensive study of the molecular and metabolic components that contribute to cell and tissue deterioration in the case of ETC dysfunction. The goals are to identify genes controlling the function and integrity of ETC complexes, to define how ETC dysfunction impacts cellular metabolism, with a special focus on redox-sensitive pathways, and elucidate brain-specific signalling that impacts mitochondrial dysfunction. The MitoCure is an ambitious project to obtain novel information about genes, metabolic pathways and signalling mechanisms underlying the pathophysiology associated with mitochondrial dysfunction.

Programme(s)

• H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)

Topic(s)

• ERC-2020-STG - ERC STARTING GRANTS

Call for proposal

ERC-2020-STG
See other projects for this call

Funding Scheme

ERC-STG - Starting Grant

Host institution

UNIVERSIDAD AUTONOMA DE MADRID

Address

Calle Einstein 3 Ciudad Univ Cantoblanco Rectorado
28049 Madrid
Spain

Activity type

Higher or Secondary Education Establishments

EU contribution

€ 1 463 410

Beneficiaries (1)

UNIVERSIDAD AUTONOMA DE MADRID

Spain

EU contribution

€ 1 463 410

Address

Calle Einstein 3 Ciudad Univ Cantoblanco Rectorado
28049 Madrid

Activity type

Higher or Secondary Education Establishments