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Evolution of neuronal cell types, development and circuitry in the insect visual system: breaking down behavioural evolution into its constituent elements

Descripción del proyecto

Información nueva sobre la manera en que evolucionan los comportamientos

¿De qué manera evolucionan los mecanismos responsables del desarrollo neuronal y qué efecto tienen sobre la diversidad neuronal? Esta es una de las principales preguntas que busca responder el proyecto financiado con fondos europeos BehaEvoDevo. Investigará la evolución y el desarrollo conductuales usando como modelo el sistema visual de los insectos, concretamente el de la mosca «Drosophila». El trabajo de BehaEvoDevo proporcionará la primera evaluación completa de los mecanismos que impulsan la evolución de comportamientos nuevos en insectos. También proporcionará un modelo que la comunidad podrá usar para comparar sus datos en distintos clados del árbol filogenético y con diversas modalidades sensoriales.

Objetivo

One of the holy grails of neuroscience is to understand how complex behaviours arise. However, surprisingly little is known about how behaviours evolve. My proposal will delve into Behavioural Evolution and Development (BehaEvoDevo) in an unbiased and comprehensive way using the insect visual system as a model. The visual system of Drosophila has been described extensively in terms of cell type composition, development, circuitry, and behaviour. My expertise in this system will be the springboard to address four fundamental questions: 1) How different is the cell type composition in the brains of different animals? 2) How do the mechanisms that are responsible for neuronal development evolve and how do they affect neuronal diversity? 3) What are the differences in the circuitry that underlies specific behaviours in different animals? 4) How do differences in neuronal composition, neuronal features, or circuitry drive different behaviours? I will combine cutting edge techniques, such as single-cell sequencing, with advanced genetic tools in Drosophila, and adapt innovative tools for genetic manipulation and circuit function in different non-model insects. I will compare how cell type composition, neuronal specification and differentiation, as well as circuitry, affect specific behaviours. I will examine phylogenetically diverse insects to generate a deep understanding of the mechanisms that are most important for the evolution of different behaviours. Moreover, I will identify fundamental principles about how developmental processes, such as neuronal specification and differentiation, evolve to control different behaviours. The cumulative results of this proposal will offer the first comprehensive assessment of the mechanisms that drive evolution of new behaviours across insects; it will also generate a blueprint for the community to compare their data in different clades of the phylogenetic tree as well as to different sensory modalities.

Régimen de financiación

ERC-STG - Starting Grant

Institución de acogida

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Aportación neta de la UEn
€ 1 632 647,00
Dirección
RUE MICHEL ANGE 3
75794 Paris
Francia

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Región
Ile-de-France Ile-de-France Paris
Tipo de actividad
Research Organisations
Enlaces
Coste total
€ 1 632 647,00

Beneficiarios (1)